The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Combining Electrospun Scaffolds with Electrosprayed Hydrogels Leads to Three-Dimensional Cellularization of Hybrid Constructs
Abstract
A common problem in the design of tissue engineered scaffolds using electrospun scaffolds is the poor cellular infiltration into the structure. To tackle this issue, three approaches to scaffold design using electrospinning were investigated: selective leaching of a water-soluble fiber phase (poly ethylene oxide (PEO) or gelatin), the use of micron-sized fibers as the scaffold, and a combination of micron-sized fibers with codeposition of a hyaluronic acid-derivative hydrogel, Heprasil. These designs were achieved by modifying a conventional electrospinning system with two charged capillaries and a rotating mandrel collector. Three types of scaffolds were fabricated: medical grade poly(epsilon-caprolactone)/collagen (mPCL/Col) cospun with PEO or gelatin, mPCL/Col meshes with micron-sized fibers, and mPCL/Col microfibers cosprayed with Heprasil. All three scaffold types supported attachment and proliferation of human fetal osteoblasts. However, selective leaching only marginally improved cellular infiltration when compared to meshes obtained by conventional electrospinning. Better cell penetration was seen in mPCL/Col microfibers, and this effect was more pronounced when Heprasil regions were present in the structure. Thus, such techniques could be further exploited for the design of cell permeable fibrous meshes for tissue engineering applications.
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Cites
Electrospinning of Nanofibers: Reinventing the Wheel?
Li, D., & Xia, Y. (2004) · Advanced Materials · doi:10.1002/adma.200400719 · Cited by 5,521
The effect of processing variables on the morphology of electrospun nanofibers and textiles
Deitzel, J. M., Kleinmeyer, J., Harris, D., & Beck Tan, N. C. (2001) · Polymer · doi:10.1016/s0032-3861(00)00250-0 · Cited by 2,915
Min, B.-M., Lee, G., Kim, S. H., Nam, Y. S., Lee, T. S., & Park, W. H. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2003.08.045 · Cited by 1,151
Electrospinning of gelatin fibers and gelatin/PCL composite fibrous scaffolds
Zhang, Y., Ouyang, H., Lim, C. T., Ramakrishna, S., & Huang, Z. (2005) · Journal of Biomedical Materials Research Part B: Applied Biomaterials · doi:10.1002/jbm.b.30128 · Cited by 1,074
Potential of Nanofiber Matrix as Tissue-Engineering Scaffolds
Ma, Z., Kotaki, M., Inai, R., & Ramakrishna, S. (2005) · Tissue Engineering · doi:10.1089/ten.2005.11.101 · Cited by 1,032
Pham, Q. P., Sharma, U., & Mikos, A. G. (2006) · Biomacromolecules · doi:10.1021/bm060680j · Cited by 956
Mo, X. M., Xu, C. Y., Kotaki, M., & Ramakrishna, S. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2003.08.042 · Cited by 803
Human bone marrow stromal cell responses on electrospun silk fibroin mats
Jin, H.-J., Chen, J., Karageorgiou, V., Altman, G. H., & Kaplan, D. L. (2004) · Biomaterials · doi:10.1016/s0142-9612(03)00609-4 · Cited by 631
Kidoaki, S., Kwon, I. K., & Matsuda, T. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.01.063 · Cited by 548
He, W., Ma, Z., Yong, T., Teo, W. E., & Ramakrishna, S. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.05.049 · Cited by 468
Leach, J. B., & Schmidt, C. E. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.02.018 · Cited by 430
Electrospinning of nanofibers with core-sheath, hollow, or porous structures
McCann, J. T., Li, D., & Xia, Y. (2005) · Journal of Materials Chemistry · doi:10.1039/b415094e · Cited by 429
Cai, S., Liu, Y., Zheng Shu, X., & Prestwich, G. D. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.03.012 · Cited by 422
Self-citationImproved Cellular Infiltration in Electrospun Fiber via Engineered Porosity
Nam, J., Huang, Y., Agarwal, S., & Lannutti, J. (2007) · Tissue Engineering · doi:10.1089/ten.2006.0306 · Cited by 414
Review. Hyaluronan: A Powerful Tissue Engineering Tool
Allison, D. D., & Grande-Allen, K. J. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.2131 · Cited by 400
He, W., Yong, T., Teo, W. E., Ma, Z., & Ramakrishna, S. (2005) · Tissue Engineering · doi:10.1089/ten.2005.11.1574 · Cited by 370
Statistical geometry of pores and statistics of porous nanofibrous assemblies
Eichhorn, S. J., & Sampson, W. W. (2005) · Journal of The Royal Society Interface · doi:10.1098/rsif.2005.0039 · Cited by 350
Hutmacher, D. W., & Cool, S. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00078.x · Cited by 256
Self-citationElectrospinning Approaches Toward Scaffold Engineering—A Brief Overview
Boudriot, U., Dersch, R., Greiner, A., & Wendorff, J. H. (2006) · Artificial Organs · doi:10.1111/j.1525-1594.2006.00301.x · Cited by 255
Shin, H. J., Lee, C. H., Cho, I. H., Kim, Y.-J., Lee, Y.-J., Kim, I. A., Park, K.-D., Yui, N., & Shin, J.-W. (2006) · Journal of Biomaterials Science, Polymer Edition · doi:10.1163/156856206774879126 · Cited by 248
Venugopal, J. R., Zhang, Y., & Ramakrishna, S. (2006) · Artificial Organs · doi:10.1111/j.1525-1594.2006.00239.x · Cited by 225
The Role of Hyaluronic Acid in Wound Healing: Assessment of Clinical Evidence
Price, R. D., Myers, S., Leigh, I. M., & Navsaria, H. A. (2005) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200506060-00006 · Cited by 215
Liu, Y., Cai, S., Shu, X. Z., Shelby, J., & Prestwich, G. D. (2007) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2007.00211.x · Cited by 174
Self-citationPrestwich, G. D. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21386 · Cited by 152
Self-citationDual growth factor-induced angiogenesis in vivo using hyaluronan hydrogel implants
Peattie, R. A., Rieke, E. R., Hewett, E. M., Fisher, R. J., Shu, X. Z., & Prestwich, G. D. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.09.035 · Cited by 143
Self-citationScaffolds, Stem Cells, and Tissue Engineering: A Potent Combination!
Cao, Y., Croll, T. I., Lees, J. G., Tuch, B. E., & Cooper-White, J. J. (2005) · Australian Journal of Chemistry · doi:10.1071/ch05145 · Cited by 28
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Malikmammadov, E., Tanir, T. E., Kiziltay, A., Hasirci, V., & Hasirci, N. (2018) · Journal of Biomaterials Science, Polymer Edition · doi:10.1080/09205063.2017.1394711 · Cited by 894
Phipps, M. C., Clem, W. C., Grunda, J. M., Clines, G. A., & Bellis, S. L. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2011.09.080 · Cited by 287
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Pidhatika, B., Rodenstein, M., Chen, Y., Rakhmatullina, E., Mühlebach, A., Acikgöz, C., Textor, M., & Konradi, R. (2012) · Biointerphases · doi:10.1007/s13758-011-0001-y · Cited by 251
Fiber density modulates cell spreading in 3D interstitial matrix mimetics
Matera, D. L., Wang, W. Y., Smith, M. R., Shikanov, A., & Baker, B. M. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b00141 · Cited by 75
Zhao, H., Tang, J., Zhou, D., Weng, Y., Qin, W., Liu, C., Lv, S., Wang, W., & Zhao, X. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s238800 · Cited by 51
Metadata
- Authors
- Ekaputra, A. K., Prestwich, G. D., Cool, S. M., & Hutmacher, D. W.
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-07-23
- Volume
- 9
- Issue
- 8
- Pages
- 2097-2103
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W1512207636
- Cited by
- 253
- References
- 26
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- closed
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