The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Identification of Direct Protein Targets of Small Molecules
Open accessAbstract
Small-molecule target identification is a vital and daunting task for the chemical biology community as well as for researchers interested in applying the power of chemical genetics to impact biology and medicine. To overcome this "target ID" bottleneck, new technologies are being developed that analyze protein-drug interactions, such as drug affinity responsive target stability (DARTS), which aims to discover the direct binding targets (and off targets) of small molecules on a proteome scale without requiring chemical modification of the compound. Here, we review the DARTS method, discuss why it works, and provide new perspectives for future development in this area.
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Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery
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The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
Chin, R. M., Fu, X., Pai, M. Y., Vergnes, L., Hwang, H., Deng, G., Diep, S., Lomenick, B., Meli, V. S., Monsalve, G. C., et al. (2014) · Nature · doi:10.1038/nature13264 · Cited by 608
Self-citationTarget Identification for Small Bioactive Molecules: Finding the Needle in the Haystack
Ziegler, S., Pries, V., Hedberg, C., & Waldmann, H. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201208749 · Cited by 466
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Montaser, R., & Luesch, H. (2011) · Future Medicinal Chemistry · doi:10.4155/fmc.11.118 · Cited by 437
Metadata
- Authors
- Lomenick, B., Olsen, R. W., & Huang, J.
- Venue
- ACS Chemical Biology
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-11-30
- Volume
- 6
- Issue
- 1
- Pages
- 34-46
- ISSN
- 1554-8929 (ISSN-L)
- 1554-8937
- OpenAlex
- W1999010280
- Cited by
- 299
- References
- 15
- FWCI
- 7.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
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