The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Marine Natural Products: A New Wave of Drugs?
Open accessAbstract
The largely unexplored marine world that presumably harbors the most biodiversity may be the vastest resource to discover novel 'validated' structures with novel modes of action that cover biologically relevant chemical space. Several challenges, including the supply problem and target identification, need to be met for successful drug development of these often complex molecules; however, approaches are available to overcome the hurdles. Advances in technologies such as sampling strategies, nanoscale NMR for structure determination, total chemical synthesis, fermentation and biotechnology are all crucial to the success of marine natural products as drug leads. We illustrate the high degree of innovation in the field of marine natural products, which in our view will lead to a new wave of drugs that flow into the market and pharmacies in the future.
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Citations
Cites
Natural products as sources of new drugs over the last 25 years
Newman, D. J., & Cragg, G. M. (2007) · Journal of Natural Products · doi:10.1021/np068054v · Cited by 5,517
Marine natural products as anticancer drugs
Simmons, T. L., Andrianasolo, E., McPhail, K., Flatt, P., & Gerwick, W. H. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.333.4.2 · Cited by 597
Schmidt, E. W., Nelson, J. T., Rasko, D. A., Sudek, S., Eisen, J. A., Haygood, M. G., & Ravel, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501424102 · Cited by 567
Halichondrins-antitumor polyether macrolides from a marine sponge
Hirata, Y., & Uemura, D. (1986) · Pure and Applied Chemistry · doi:10.1351/pac198658050701 · Cited by 519
Taori, K., Paul, V. J., & Luesch, H. (2008) · Journal of the American Chemical Society · doi:10.1021/ja7110064 · Cited by 428
Self-citationLuesch, H., Yoshida, W. Y., Moore, R. E., Paul, V. J., & Corbett, T. H. (2001) · Journal of the American Chemical Society · doi:10.1021/ja010453j · Cited by 373
Self-citationDiscovery and development of the anticancer agent salinosporamide A (NPI-0052)
Fenical, W., Jensen, P. R., Palladino, M. A., Lam, K. S., Lloyd, G. K., & Potts, B. C. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2008.10.075 · Cited by 291
Clinical status of anti-cancer agents derived from marine sources
Singh, R., Sharma, M., Joshi, P., & Rawat, D. (2008) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152008785133074 · Cited by 143
Cited by
Faulkner, D. J. (1990) · Natural Product Reports · doi:10.1039/np9900700269 · Cited by 4,866
Blunt, J. W., Copp, B. R., Keyzers, R. A., Munro, M. H. G., & Prinsep, M. R. (2013) · Nat. Prod. Rep. · doi:10.1039/c2np20112g · Cited by 518
Largazole: From discovery to broad-spectrum therapy
Hong, J., & Luesch, H. (2012) · Natural Product Reports · doi:10.1039/c2np00066k · Cited by 174
Self-citationMarine-Derived Compounds with Potential Use as Cosmeceuticals and Nutricosmetics
Alves, A., Sousa, E., Kijjoa, A., & Pinto, M. (2020) · Molecules · doi:10.3390/molecules25112536 · Cited by 169
Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials
Choudhary, A., Naughton, L., Montánchez, I., Dobson, A., & Rai, D. (2017) · Marine Drugs · doi:10.3390/md15090272 · Cited by 138
Metadata
- Authors
- Montaser, R., & Luesch, H.
- Venue
- Future Medicinal Chemistry
- Publisher
- Informa UK Limited
- Published
- 2011-09
- Volume
- 3
- Issue
- 12
- Pages
- 1475-1489
- ISSN
- 1756-8919 (ISSN-L)
- 1756-8927
- OpenAlex
- W2032889069
- Cited by
- 437
- References
- 8
- FWCI
- 12.77
- Type
- journal article
- Language
- en
- Open access
- green
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
