The DOI matches its Crossref record.
A Protein Nanocarrier from Charge-Conversion Polymer in Response to Endosomal pH
Abstract
A new type of polyion complex (PIC) micelle was prepared from lysozyme and the block copolymer, PEG-pAsp(EDA-Cit), that can switch the charge from anionic to cationic at the endosomal pH. The charge-conversion was due to the degradation of the citraconic amide side chain at pH 5.5. This abrupt charge-conversion can make the PIC micelles promptly release the internal protein in response to the endosomal pH. This pH-sensitive charge-conversion polymer is promising for the future design of nanocarriers for early endosomal release.
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Metadata
- Authors
- Lee, Y., Fukushima, S., Bae, Y., Hiki, S., Ishii, T., & Kataoka, K.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-04-05
- Volume
- 129
- Issue
- 17
- Pages
- 5362-5363
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2061093127
- Cited by
- 404
- References
- 0
- FWCI
- 9.96
- Type
- journal article
- Language
- en
- Open access
- closed
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