The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Enhanced NIR Radiation-Triggered Hyperthermia by Mitochondrial Targeting
Abstract
Mitochondria are organelles that are readily susceptible to temperature elevation. We selectively delivered a coumarin-based fluorescent iron oxide nanoparticle, Mito-CIO, to the mitochondria. Upon 740 nm laser irradiation, the intracellular temperature of HeLa cells was elevated by 2.1 °C within 5 min when using Mito-CIO, and the treatment resulted in better hyperthermia and a more elevated cytotoxicity than HeLa cells treated with coumarin iron oxide (CIO), which was missing the mitochondrial targeting unit. We further confirmed these results in a tumor xenograft mouse model. To our knowledge, this is the first report of a near-infrared laser irradiation-induced hyperthermic particle targeted to mitochondria, enhancing the cytotoxicity in cancer cells. Our present work therefore may open a new direction in the development of photothermal therapeutics.
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Cites
Ultra-large-scale syntheses of monodisperse nanocrystals
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Self-citationColloidal nanocrystal synthesis and the organic–inorganic interface
Yin, Y., & Alivisatos, A. P. (2005) · Nature · doi:10.1038/nature04165 · Cited by 3,273
Exploiting the enhanced permeability and retention effect for tumor targeting
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Fluorescent and luminescent probes for detection of reactive oxygen and nitrogen species
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The Role of Mitochondria-Derived Reactive Oxygen Species in Hyperthermia-Induced Platelet Apoptosis
Wang, Z., Cai, F., Chen, X., Luo, M., Hu, L., & Lu, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075044 · Cited by 155
Cited by
Zielonka, J., Joseph, J., Sikora, A., Hardy, M., Ouari, O., Vasquez-Vivar, J., Cheng, G., Lopez, M., & Kalyanaraman, B. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00042 · Cited by 1,683
Cancer drug delivery in the nano era: An overview and perspectives
Li, Z., Tan, S., Li, S., Shen, Q., & Wang, K. (2017) · Oncology Reports · doi:10.3892/or.2017.5718 · Cited by 406
Recent Advances in Subcellular Targeted Cancer Therapy Based on Functional Materials
Chen, W., Luo, G., & Zhang, X. (2019) · Advanced Materials · doi:10.1002/adma.201802725 · Cited by 373
A Mitochondria-Targeted Cryptocyanine-Based Photothermogenic Photosensitizer
Jung, H. S., Lee, J.-H., Kim, K., Koo, S., Verwilst, P., Sessler, J. L., Kang, C., & Kim, J. S. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b04263 · Cited by 371
Self-citationA Dual‐Targeted Organic Photothermal Agent for Enhanced Photothermal Therapy
Wang, H., Chang, J., Shi, M., Pan, W., Li, N., & Tang, B. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201811273 · Cited by 325
Mitochondria‐Targeted Small‐Molecule Fluorophores for Dual Modal Cancer Phototherapy
Luo, S., Tan, X., Fang, S., Wang, Y., Liu, T., Wang, X., Yuan, Y., Sun, H., Qi, Q., & Shi, C. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201600159 · Cited by 285
Li, W., Li, X., Chang, W., Wu, J., Liu, P., Wang, J., Yao, X., & Yu, Z.-Z. (2020) · Nano Research · doi:10.1007/s12274-020-2970-y · Cited by 282
Cheng, Z., Zhang, T., Wang, W., Shen, Q., Hong, Y., Shao, J., Xie, X., Fei, Z., & Dong, X. (2021) · Chinese Chemical Letters · doi:10.1016/j.cclet.2021.02.017 · Cited by 76
Pan, G.-Y., Jia, H.-R., Zhu, Y.-X., & Wu, F.-G. (2018) · Nanoscale · doi:10.1039/c7nr07495f · Cited by 74
Yu, J.-F., Li, J., & Li, M. (2024) · ACS Sensors · doi:10.1021/acssensors.4c00561 · Cited by 16
Metadata
- Authors
- Jung, H. S., Han, J., Lee, J.-H., Lee, J. H., Choi, J.-M., Kweon, H.-S., Han, J. H., Kim, J.-H., Byun, K. M., Jung, J. H., Kang, C., & Kim, J. S.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-02-17
- Volume
- 137
- Issue
- 8
- Pages
- 3017-3023
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W2319084466
- Cited by
- 181
- References
- 5
- FWCI
- 12.27
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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