The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
An ICT-Based Approach to Ratiometric Fluorescence Imaging of Hydrogen Peroxide Produced in Living Cells
Abstract
We present the synthesis, properties, and biological applications of Peroxy Lucifer 1 (PL1), a new fluorescent probe for imaging hydrogen peroxide produced in living cells by a ratiometric response. PL1 utilizes a chemoselective boronate-based switch to detect hydrogen peroxide by modulation of internal charge transfer (ICT) within a 1,8-naphthalimide dye. PL1 features high selectivity for hydrogen peroxide over similar reactive oxygen species, including superoxide, and nitric oxide, and a 65 nm shift in emission from blue-colored fluorescence to green-colored fluorescence upon reaction with peroxide. Two-photon confocal microscopy experiments in live macrophages show that PL1 can ratiometrically visualize localized hydrogen peroxide bursts generated in living cells at immune response levels.
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Cites
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Metadata
- Authors
- Srikun, D., Miller, E. W., Domaille, D. W., & Chang, C. J.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-03-13
- Volume
- 130
- Issue
- 14
- Pages
- 4596-4597
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1985802355
- Cited by
- 543
- References
- 9
- FWCI
- 11.28
- Type
- journal article
- Language
- en
- Open access
- closed
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