The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
What the Cell “Sees” in Bionanoscience
Abstract
What the biological cell, organ, or barrier actually "sees" when interacting with a nanoparticle dispersed in a biological medium likely matters more than the bare material properties of the particle itself. Typically the bare surface of the particle is covered by several biomolecules, including a select group of proteins drawn from the biological medium. Here, we apply several different methodologies, in a time-resolved manner, to follow the lifetime of such biomolecular "coronas" both in situ and isolated from the excess plasma. We find that such particle-biomolecule complexes can be physically isolated from the surrounding medium and studied in some detail, without altering their structure. For several nanomaterial types, we find that blood plasma-derived coronas are sufficiently long-lived that they, rather than the nanomaterial surface, are likely to be what the cell sees. From fundamental science to regulatory safety, current efforts to classify the biological impacts of nanomaterials (currently according to bare material type and bare surface properties) may be assisted by the methodology and understanding reported here.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The effect of particle design on cellular internalization pathways
Gratton, S. E. A., Ropp, P. A., Pohlhaus, P. D., Luft, J. C., Madden, V. J., Napier, M. E., & DeSimone, J. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801763105 · Cited by 2,918
My voyage of discovery to proteins in flatland … and beyond
Norde, W. (2008) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2007.09.029 · Cited by 326
Research works printed but not linked: 26
- Watson P., 2005, Adv. Drug Delivery Rev., 57, 43, 10.1016/j.addr.2004.05.003 · DOI · Paper page
- Jiang W., 2008, Nat. Nanotechnol., 3, 145, 10.1038/nnano.2008.30 · DOI · Paper page
- Rejman J., 2004, Biochem. J., 377, 159, 10.1042/bj20031253 · DOI · Paper page
- Chithrani B. D., 2007, Nano Lett., 7, 1542, 10.1021/nl070363y · DOI · Paper page
- Mahmoudi M., 2009, J. Phys. Chem. C, 113, 9573, 10.1021/jp9001516 · DOI
- Ehrenberg M. S., 2009, Biomaterials, 30, 603, 10.1016/j.biomaterials.2008.09.050 · DOI · Paper page
- Cedervall T., 2007, Angew. Chem., 46, 5754, 10.1002/anie.200700465 · DOI · Paper page
- Cedervall T., 2007, Proc. Natl. Acad. Sci. U. S. A., 104, 2050, 10.1073/pnas.0608582104 · DOI · Paper page
- Chanteau B., 2009, Langmuir, 25, 9064, 10.1021/la900833v · DOI
- Göppert T. M., 2005, Int. J. Pharmacol., 302, 172, 10.1016/j.ijpharm.2005.06.025 · DOI · Paper page
- Lindman S., 2007, Nano Lett., 7, 914, 10.1021/nl062743+ · DOI · Paper page
- Lundqvist M., 2008, Proc. Natl. Acad. Sci. U. S. A., 105, 14265, 10.1073/pnas.0805135105 · DOI · Paper page
- Nel A., 2009, Nat. Mater., 8, 543, 10.1038/nmat2442 · DOI · Paper page
- 1999, Physical Chemistry of Biological-Interfaces
- Lynch I., 2008, Nanotoday, 3, 40, 10.1016/S1748-0132(08)70014-8 · DOI · Paper page
- Simberg D., 2009, Biomaterials, 30, 3926, 10.1016/j.biomaterials.2009.03.056 · DOI · Paper page
- Mu Q., 2009, J. Phys. Chem. C, 113, 5390, 10.1021/jp809493t · DOI
- Hellstrand E., 2009, FEBS, 276, 3372, 10.1111/j.1742-4658.2009.07062.x · DOI · Paper page
- Lynch I., 2007, Adv. Colloid Interface Sci., 167, 134
- Röcker C., 2009, Nat. Nanotechnol., 4, 577, 10.1038/nnano.2009.195 · DOI · Paper page
- Rezwan K., 2005, J. Phys. Chem. B, 109, 14469, 10.1021/jp050528w · DOI · Paper page
- Xiao Q., 2009, Nanotechnology, 20, 325101, 10.1088/0957-4484/20/32/325101 · doi:10.1088/0957-4484/20/32/325101
- Aubin-Tam M.-E., 2008, Biomed. Mater., 3, 034001, 10.1088/1748-6041/3/3/034001 · DOI · Paper page
- Vauthiera C., 2009, Colloids Surf., B, 69, 207, 10.1016/j.colsurfb.2008.11.017 · DOI
- Dobrovolskaia M. A., 2009, Nanomedicine, 5, 106, 10.1016/j.nano.2008.08.001 · DOI · Paper page
- Shen H.-H., 2009, Langmuir, 25, 4211, 10.1021/la802913x · DOI
Cited by
Biomolecular coronas provide the biological identity of nanosized materials
Monopoli, M. P., Åberg, C., Salvati, A., & Dawson, K. A. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.207 · Cited by 3,017
Self-citationCellular uptake of nanoparticles: Journey inside the cell
Behzadi, S., Serpooshan, V., Tao, W., Hamaly, M. A., Alkawareek, M. Y., Dreaden, E. C., Brown, D., Alkilany, A. M., Farokhzad, O. C., & Mahmoudi, M. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00636a · Cited by 2,859
Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology
Tenzer, S., Docter, D., Kuharev, J., Musyanovych, A., Fetz, V., Hecht, R., Schlenk, F., Fischer, D., Kiouptsi, K., Reinhardt, C., et al. (2013) · Nature Nanotechnology · doi:10.1038/nnano.2013.181 · Cited by 2,283
Interactions of microplastic debris throughout the marine ecosystem
Galloway, T. S., Cole, M., & Lewis, C. (2017) · Nature Ecology & Evolution · doi:10.1038/s41559-017-0116 · Cited by 1,955
Salvati, A., Pitek, A. S., Monopoli, M. P., Prapainop, K., Bombelli, F. B., Hristov, D. R., Kelly, P. M., Åberg, C., Mahon, E., & Dawson, K. A. (2013) · Nature Nanotechnology · doi:10.1038/nnano.2012.237 · Cited by 1,912
Self-citation
Metadata
- Authors
- Walczyk, D., Bombelli, F. B., Monopoli, M. P., Lynch, I., & Dawson, K. A.
- Venue
- Journal of the American Chemical Society
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-03-31
- Volume
- 132
- Issue
- 16
- Pages
- 5761-5768
- ISSN
- 0002-7863 (ISSN-L)
- 1520-5126
- OpenAlex
- W1995704440
- Cited by
- 1,184
- References
- 2
- FWCI
- 35.40
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: What the Cell “Sees” in Bionanoscience. https://app.cochat.ai/papers/10.1021/ja910675v
- The paper
- Walczyk, D., Bombelli, F. B., Monopoli, M. P., Lynch, I., & Dawson, K. A. (2010). What the Cell “Sees” in Bionanoscience. Journal of the American Chemical Society. https://doi.org/10.1021/ja910675v
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
