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Cited by 277

The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.

Potential Therapeutic Applications of Some Antinutritional Plant Secondary Metabolites

Singh, Birbal, Bhat, Tej K., Singh, Bhupinder·2003·Journal of Agricultural and Food Chemistry
DOI 10.1021/jf021150r
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Abstract

Plant-based formulations have been used since ancient times as remedial measures against various human and animal ailments. Over the past 20 years interest in traditional medicines has increased considerably in many parts of the world. Whereas modifications in lifestyles, including diet, have had a profound effect on the increased risks of various diseases, there is considerable scientific evidence, both epidemiological and experimental, regarding vegetables and fruits as key features of diets associated with reduced risks of diseases such as cancers and infections. This has led to the use of a number of phytometabolites as anticarcinogenic and cardioprotective agents, promoting a dramatic increase in their consumption as dietary supplements. There are changing perceptions regarding the therapeutic potential of various plant secondary metabolites (PSMs), some of which have also been known to possess certain antinutritional qualities. The knowledge gained at the cellular and molecular levels, and biological activities of PSMs including tannin-polyphenols, saponins, mimosine, flavonoids, terpenoids, and phytates, would be useful in planning for future epidemiological studies and human cancer prevention trials, especially when a large pure dosage is not the option to deliver the active compounds to many tissues. It is well observed that alteration of cell cycle regulatory gene expression is frequently found in tumor tissues or cancer cell lines, and studies have suggested that the herbal-based or plant-originated cell cycle regulators might represent a new set of potential targets for anticancer drugs. The recent upsurge of interest in this area of research and advances made therein indicate that the impact of a number of diseases affecting humans and animals may be lessened, if not prevented, by simple dietary intake of PSMs with putative therapeutic properties.

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Metadata

Authors
Singh, B., Bhat, T. K., & Singh, B.
Venue
Journal of Agricultural and Food Chemistry
Publisher
American Chemical Society (ACS)
Published
2003-08-14
Volume
51
Issue
19
Pages
5579-5597
ISSN
  • 0021-8561 (ISSN-L)
  • 1520-5118
DOI
10.1021/jf021150r
OpenAlex
W2066480167
Cited by
277
References
101
FWCI
3.68
Type
journal article
Language
en
Open access
closed

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