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Inhibition of Angiotensin Converting Enzyme Activity by Flavanol-Rich Foods
Abstract
Angiotensin converting enzyme (ACE) activity was evaluated in the presence of flavanol-rich foods, i.e., wines, chocolates, and teas, and of purified flavonoids. All foods assayed inhibited ACE activity, red wines being more effective than white wine, and green tea more effective than black tea. The inhibition of ACE activity was associated with both phenolic and flavanol content in the foods. When isolated polyphenols were assayed, procyanidins (dimer and hexamer) and epigallocatechin significantly inhibited enzyme activity; similar concentrations of (+)-catechin, (-)-epicatechin, gallic acid, chlorogenic acid, caffeic acid, quercetin, kaempferol, and resveratrol were ineffective. When ACE activity was assayed in rat kidney membranes in the presence of chocolate extracts or purified procyanidins, it was observed that the inhibition depended on the chocolate content of flavanols and the number of flavanol units constituting the procyanidin. These experiments demonstrate that flavanols either isolated or present in foods could inhibit ACE activity. The occurrence of such inhibition in vivo needs to be determined, although is supported by the association between the consumption of flavanol-rich foods and reductions in blood pressure observed in several experimental models.
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Cites
Middleton, E., Kandaswami, C., & Theoharides, T. C. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01472-8 · Cited by 4,882
Flavonoids: a review of probable mechanisms of action and potential applications
Nijveldt, R. J., van Nood, E., van Hoorn, D. E., Boelens, P. G., van Norren, K., & van Leeuwen, P. A. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.4.418 · Cited by 3,075
Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung
Cushman, D. W., & Cheung, H. S. (1971) · Biochemical Pharmacology · doi:10.1016/0006-2952(71)90292-9 · Cited by 2,625
Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine
Frankel, E. N., German, J. B., Kinsella, J. E., Parks, E., & Kanner, J. (1993) · The Lancet · doi:10.1016/0140-6736(93)90206-v · Cited by 1,647
Fruit and vegetable intake and risk of major chronic disease
Hung, H.-C., Joshipura, K. J., Jiang, R., Hu, F. B., Hunter, D., Smith-Warner, S. A., Colditz, G. A., Rosner, B., Spiegelman, D., & Willett, W. C. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh296 · Cited by 1,327
A Critical Evaluation of the Vanillin Reaction as an Assay for Tannin in Sorghum Grain
Price, M. L., Van Scoyoc, S., & Butler, L. G. (1978) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf60219a031 · Cited by 1,317
Critical Factors of Vanillin Assay for Catechins and Proanthocyanidins
Sun, B., Ricardo-da-Silva, J. M., & Spranger, I. (1998) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf980366j · Cited by 1,099
Cocoa Has More Phenolic Phytochemicals and a Higher Antioxidant Capacity than Teas and Red Wine
Lee, K. W., Kim, Y. J., Lee, H. J., & Lee, C. Y. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0344385 · Cited by 748
Fogliano, V., Verde, V., Randazzo, G., & Ritieni, A. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf980496s · Cited by 640
Duffy, S. J., Keaney Jr, J. F., Holbrook, M., Gokce, N., Swerdloff, P. L., Frei, B., & Vita, J. A. (2001) · Circulation · doi:10.1161/01.cir.104.2.151 · Cited by 552
Holt, R. R., Lazarus, S. A., Sullards, M. C., Zhu, Q. Y., Schramm, D. D., Hammerstone, J. F., Fraga, C. G., Schmitz, H. H., & Keen, C. L. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.4.798 · Cited by 521
Self-citationGrassi, D., Lippi, C., Necozione, S., Desideri, G., & Ferri, C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.3.611 · Cited by 508
Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans
Fisher, N. D., Hughes, M., Gerhard-Herman, M., & Hollenberg, N. K. (2003) · Journal of Hypertension · doi:10.1097/00004872-200312000-00016 · Cited by 502
Determination of Tea Components with Antioxidant Activity
Cabrera, C., Giménez, R., & López, M. C. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0300801 · Cited by 462
Hammerstone, J. F., Lazarus, S. A., Mitchell, A. E., Rucker, R., & Schmitz, H. H. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf980760h · Cited by 455
Quantitative Analysis of Flavan-3-ols in Spanish Foodstuffs and Beverages
de Pascual-Teresa, S., Santos-Buelga, C., & Rivas-Gonzalo, J. C. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf000549h · Cited by 436
Vascular effects of cocoa rich in flavan-3-ols
Heiss, C. (2003) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.290.8.1030 · Cited by 425
Evidence that the antioxidant flavonoids in tea and cocoa are beneficial for cardiovascular health
Kris-Etherton, P. M., & Keen, C. L. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200202000-00007 · Cited by 393
Evidence for health benefits of plant phenols: local or systemic effects?
Hollman, P. C. H. (2001) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.900 · Cited by 378
Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function
Murphy, K. J., Chronopoulos, A. K., Singh, I., Francis, M. A., Moriarty, H., Pike, M. J., Turner, A. H., Mann, N. J., & Sinclair, A. J. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.6.1466 · Cited by 373
Procyanidin content and variation in some commonly consumed foods
Hammerstone, J. F., Lazarus, S. A., & Schmitz, H. H. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.8.2086s · Cited by 356
Metabolism of dietary procyanidins in rats
Gonthier, M.-P., Donovan, J. L., Texier, O., Felgines, C., Remesy, C., & Scalbert, A. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00394-0 · Cited by 345
Antioxidant Capacities and Phenolics Levels of French Wines from Different Varieties and Vintages
Landrault, N., Poucheret, P., Ravel, P., Gasc, F., Cros, G., & Teissedre, P.-L. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010128f · Cited by 327
Arts, I. C. W., van de Putte, B., & Hollman, P. C. H. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf000026+ · Cited by 318
Chocolate and Blood Pressure in Elderly Individuals With Isolated Systolic Hypertension
Taubert, D. (2003) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.290.8.1029 · Cited by 298
Ehlers, M. R., Fox, E. A., Strydom, D. J., & Riordan, J. F. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.20.7741 · Cited by 292
Beyond alcohol: Beverage consumption and cardiovascular mortality
Goldberg, D. M., Hahn, S. E., & Parkes, J. G. (1995) · Clinica Chimica Acta · doi:10.1016/0009-8981(95)06069-p · Cited by 290
[18] Peptidyl dipeptidase A: Angiotensin I-converting enzyme
Corvol, P., Williams, T. A., & Soubrier, F. (1995) · Methods in Enzymology · doi:10.1016/0076-6879(95)48020-x · Cited by 277
Plant-derived phenolic antioxidants
Duthie, G., & Crozier, A. (2000) · Current Opinion in Lipidology · doi:10.1097/00041433-200002000-00007 · Cited by 251
Cocoa antioxidants and cardiovascular health
Keen, C. L., Holt, R. R., Oteiza, P. I., Fraga, C. G., & Schmitz, H. H. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.298s · Cited by 246
Self-citationInhibition of angiotensin converting enzyme (ACE) activity by flavan‐3‐ols and procyanidins
Actis-Goretta, L., Ottaviani, J. I., Keen, C. L., & Fraga, C. G. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01355-3 · Cited by 241
Self-citationWine Polyphenols Decrease Blood Pressure, Improve NO Vasodilatation, and Induce Gene Expression
Diebolt, M., Bucher, B., & Andriantsitohaina, R. (2001) · Hypertension · doi:10.1161/01.hyp.38.2.159 · Cited by 238
The Interaction of Flavonoids with Membranes: Potential Determinant of Flavonoid Antioxidant Effects
Erlejman, A. G., Verstraeten, S. V., Fraga, C. G., & Oteiza, P. I. (2004) · Free Radical Research · doi:10.1080/10715760400016105 · Cited by 236
Self-citationVerstraeten, S. V., Keen, C. L., Schmitz, H. H., Fraga, C. G., & Oteiza, P. I. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01185-1 · Cited by 211
Self-citationExtraction of Phenolics and Changes in Antioxidant Activity of Red Wines during Vinification
Burns, J., Gardner, P. T., Matthews, D., Duthie, G. G., Lean, J., & Crozier, A. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010682p · Cited by 197
Regular Consumption of a Flavanol‐rich Chocolate can Improve Oxidant Stress in Young Soccer Players
Fraga, C. G., Actis-Goretta, L., Ottaviani, J. I., Carrasquedo, F., Lotito, S. B., Lazarus, S., Schmitz, H. H., & Keen, C. L. (2005) · Journal of Immunology Research · doi:10.1080/10446670410001722159 · Cited by 181
Self-citationBruneval, P., Hinglais, N., Alhenc-Gelas, F., Tricottet, V., Corvol, P., Menard, J., Camilleri, J. P., & Bariety, J. (1986) · Histochemistry · doi:10.1007/bf00508656 · Cited by 176
(+)-Catechin Prevents Human Plasma Oxidation
Lotito, S. B., & Fraga, C. G. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00276-1 · Cited by 174
Self-citationAngiotensin-Converting Enzyme in Epithelial and Neuroepithelial Cells
Defending, R., Zimmerman, E. A., Weare, J. A., Alhenc‐Gelas, F., & Erdös, E. G. (2008) · Neuroendocrinology · doi:10.1159/000123512 · Cited by 150
Vascular and cardiac benefits of angiotensin receptor blockers
Schiffrin, E. L. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01241-x · Cited by 128
Levels of Flavan-3-ols in French Wines
Carando, S., Teissèdre, P., Pascual-Martinez, L., & Cabanis, J. C. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9810564 · Cited by 124
Study of Catechin and Xanthine Tea Profiles as Geographical Tracers
Fernández, P. L., Pablos, F., Martín, M. J., et al. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0114435 · Cited by 120
Goldberg, D. M. (1995) · Clinical Chemistry · doi:10.1093/clinchem/41.1.14 · Cited by 108
Tea Flavonoids: Bioavailability In Vivo and Effects on Cell Signaling Pathways In Vitro
Wiseman, S. A., MULDER, T. P. J., & Rietveld, A. G. (2001) · Antioxidants and Redox Signaling · doi:10.1089/152308601317203549 · Cited by 91
Tea Intake Is Inversely Related to Blood Pressure in Older Women
Hodgson, J. M., Devine, A., Puddey, I. B., Chan, S. Y., Beilin, L. J., & Prince, R. L. (2003) · Journal of Nutrition · doi:10.1093/jn/133.9.2883 · Cited by 77
Sensitive method for quantitation of angiotensin-converting enzyme (ACE) activity in tissue
Meng, Q. C., Balcells, E., Dell’Italia, L. J., Durand, J., & Oparil, S. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)02038-1 · Cited by 63
Concerted action of the renin–angiotensin system, mitochondria, and antioxidant defenses in aging
de Cavanagh, E. M. V., Piotrkowski, B., & Fraga, C. G. (2004) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.02.006 · Cited by 62
Self-citationStöcker, W., & Zwilling, R. (1995) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(95)48021-8 · Cited by 59
Cited by
Flavan‐3‐ols: Nature, occurrence and biological activity
Aron, P. M., & Kennedy, J. A. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700137 · Cited by 770
Dietary polyphenols: Good, bad, or indifferent for your health?
HALLIWELL, B. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.10.004 · Cited by 559
Grassi, D., Desideri, G., Necozione, S., Lippi, C., Casale, R., Properzi, G., Blumberg, J. B., & Ferri, C. (2008) · The Journal of Nutrition · doi:10.1093/jn/138.9.1671 · Cited by 481
Taubert, D., Roesen, R., Lehmann, C., Jung, N., & Schömig, E. (2007) · JAMA · doi:10.1001/jama.298.1.49 · Cited by 476
Morand, C., Dubray, C., Milenkovic, D., Lioger, D., Martin, J. F., Scalbert, A., & Mazur, A. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.004945 · Cited by 439
Metadata
- Authors
- Actis-Goretta, L., Ottaviani, J. I., & Fraga, C. G.
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-12-14
- Volume
- 54
- Issue
- 1
- Pages
- 229-234
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W1986473930
- Cited by
- 335
- References
- 48
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- closed
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