Cyclin-Dependent Kinase Inhibitors: Useful Targets in Cell Cycle Regulation

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H2O2 from the oxidative burst orchestrates the plant hypersensitive disease resistance response

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Cell Cycle Control and Cancer

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The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2

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A p16 INK4a -Insensitive CDK4 Mutant Targeted by Cytolytic T Lymphocytes in a Human Melanoma

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The p21Cip1 and p27Kip1 CDK ‘inhibitors’ are essential activators of cyclin D‐dependent kinases in murine fibroblasts

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Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

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Crystal structure of cyclin-dependent kinase 2

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NF-κB Function in Growth Control: Regulation of Cyclin D1 Expression and G 0 /G 1 -to-S-Phase Transition

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Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53

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THE DEVELOPMENT AND CLINICAL UTILITY OF THE TAXANE CLASS OF ANTIMICROTUBULE CHEMOTHERAPY AGENTS

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Inhibition of Cyclin‐Dependent Kinases by Purine Analogues

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A brain-specific activator of cyclin-dependent kinase 5

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The DNA Replication and Damage Checkpoint Pathways Induce Transcription by Inhibition of the Crt1 Repressor

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UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53

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Growth suppression by p16ink4 requires functional retinoblastoma protein

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Cyclin-dependent kinase control of centrosome duplication

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Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms.

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Targeted Disruption of CDK4 Delays Cell Cycle Entry with Enhanced p27 Kip1 Activity

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The spindle checkpoint

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The retinoblastoma protein pathway and the restriction point

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Dependence of Cyclin E-CDK2 Kinase Activity on Cell Anchorage

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What is the restriction point?

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Potent Inhibition of Cdc2 Kinase Activity by the Flavonoid L86-8275

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Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1

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Paullones, a Series of Cyclin-Dependent Kinase Inhibitors: Synthesis, Evaluation of CDK1/Cyclin B Inhibition, and in Vitro Antitumor Activity

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Fc Receptors Initiate the Arthus Reaction: Redefining the Inflammatory Cascade

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Replication Checkpoint Enforced by Kinases Cds1 and Chk1

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Cyclin/Cdk-Dependent Initiation of DNA Replication in a Human Cell-Free System

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Chaos, Persistence, and Evolution of Strain Structure in Antigenically Diverse Infectious Agents

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Cdc2 Kinase Directly Phosphorylates the cis-Golgi Matrix Protein GM130 and Is Required for Golgi Fragmentation in Mitosis

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Delayed early embryonic lethality following disruption of the murine cyclin A2 gene

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Multiple modes of ligand recognition: Crystal structures of cyclin‐dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine

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CANCER CHEMOTHERAPEUTIC AGENTS

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Induced Expression of p16INK4a Inhibits Both CDK4- and CDK2-Associated Kinase Activity by Reassortment of Cyclin-CDK-Inhibitor Complexes

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Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas

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Olomoucine, an inhibitor of the cdc2/cdk2 kinases activity, blocks plant cells at the G1 to S and G2 to M cell cycle transitions

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CVT-313, a Specific and Potent Inhibitor of CDK2 That Prevents Neointimal Proliferation

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Cdc37 is required for association of the protein kinase Cdc28 with G1 and mitotic cyclins.

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Expressed sequence tags — ESTablishing bridges between genomes

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Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells

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Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C

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Cumulative Effect of Phosphorylation of pRB on Regulation of E2F Activity

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The spindle checkpoint

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The Effect of the Cyclin-Dependent Kinase Inhibitor Olomoucine on Cell Cycle Kinetics

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Butyrate Stimulates Cyclin D and p21 and Inhibits Cyclin-Dependent Kinase 2 Expression in HT-29 Colonic Epithelial Cells

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Protein kinase regulation: insights from crystal structure analysis

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Inactivation of Cdc2 increases the level of apoptosis induced by DNA damage

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Cell Cycle and Cancer: Critical Events at the G1 Restriction Point

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Reversible tyrosine phosphorylation and cell cycle control

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Cyclin-dependent kinases: regulators of the cell cycle and more

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The therapeutic potential of targeting the cell cycle

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248th ACS National Meeting

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Inhibition of Cell Cycle Oscillation of DNA Replication by a Selective Inhibitor of the cdc2 Kinase Family, Butyrolactone I, in Xenopus Egg Extracts

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Effect of Suramin on p34cdc2 Kinase in Vitro and in Extracts from Human H69 Cells: Evidence for a Double Mechanism of Action

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A short and unequivocal synthesis of 5‐aminotetrazolo[1,5‐a]‐quinazoline as a tricyclic analogue of 4‐(3‐bromoanilino)‐6,7‐dimethoxyquinazoline (PD 153035)

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Identifying human homologs of cell cycle genes using dbEST and XREFdb

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Purification and crystallization of cyclin‐dependent kinase inhibitor p21

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Erratum: Chromatin-remodelling factor CHRAC contains the ATPases ISWI and topoisomerase II

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Protein kinase C inhibitor as a potent inhibitor of accelerated repopulation during radiotherapy: I. growth inhibitory, cytotoxic, and indirect radiosensitizing effects of a staurosporine derivative (UCN‐01) in vitro

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Pharmacological inhibitors of cyclin-dependent kinases

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Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6

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Molecular Recognition of Protein Kinase Binding Pockets for Design of Potent and Selective Kinase Inhibitors

Liao, J. J.-L. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm0608107 · Cited by 507