Nanodelivery Systems for Nucleic Acid Therapeutics in Drug Resistant Tumors

Iyer, Arun K.; Duan, Zhenfeng; Amiji, Mansoor M.

doi:10.1021/mp500024p

Cited by 55RNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryDrug Transport and Resistance Mechanisms

Nanodelivery Systems for Nucleic Acid Therapeutics in Drug Resistant Tumors

Iyer, Arun K., Duan, Zhenfeng, Amiji, Mansoor M.·2014·Molecular Pharmaceutics

DOI 10.1021/mp500024p

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Abstract

Development of intrinsic and acquired drug resistance in cancer is a significant clinical challenge for effective therapeutic outcomes. Multidrug resistance (MDR) in solid tumors is especially difficult to overcome due to the many different factors that influence clinically manifested refractory disease. Genetic profiling of MDR tumors can provide for more specific control through RNA interference (RNAi) therapy. However, there are multiple barriers to effective in vivo delivery of functional nucleic acid constructs, such as small interfering RNAs (siRNAs) and micro RNAs (miRNAs or miRs). In this review, we have briefly described the principles and mechanisms based on the RNA interference phenomenon and the barriers to its successful clinical translation. The principles of active and passive tumor targeting using nanoparticles systems are also discussed. Furthermore, illustrative examples of miRNA, siRNA, and gene-drug combination delivery using nanoparticle systems that have shown promising potentials for the treatment of diseases such as MDR cancers are covered.

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Nanodelivery of nucleic acids
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Authors: Iyer, A. K., Duan, Z., & Amiji, M. M.
Affiliations: Northeastern University (US)
Harvard University (US)
Corresponding author: Amiji, Mansoor M.
ORCID: Iyer, Arun K.
Duan, Zhenfeng
Amiji, Mansoor M.
Venue: Molecular Pharmaceutics
Publisher: American Chemical Society (ACS)
Published: 2014-04-01
Volume: 11
Issue: 8
Pages: 2511-2526
ISSN: 1543-8384 (ISSN-L)
1543-8392
DOI: 10.1021/mp500024p
OpenAlex: W2015164743
Cited by: 55
References: 128
Citations by year: 2026: 1 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 8 · 2017: 3 · 2016: 6 · 2015: 7 · 2014: 3
FWCI: 0.60
Type: journal article
Language: en
Open access: closed
Locations: Molecular Pharmaceutics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords: nanoparticle drug delivery, nucleic acid therapeutics, multidrug resistance, drug-resistant cancer, RNA interference, siRNA, microRNA, tumor targeting
MeSH terms: Animals, DNA Repair, Electron Spin Resonance Spectroscopy, Humans, Ligands, Neoplasms, Nucleic Acids, Genetic Therapy, Drug Delivery Systems, Drug Resistance, Neoplasm, Gene Silencing, RNA Interference, RNA, Small Interfering, Nanotechnology, Cell Line, Tumor, Nanomedicine, Mice, Nanoparticles

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Nanodelivery Systems for Nucleic Acid Therapeutics in Drug Resistant Tumors

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