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The Evolution of the Protein Corona around Nanoparticles: A Test Study

Lundqvist, Martin, Stigler, Johannes, Cedervall, Tommy, Berggård, Tord, Flanagan, Michelle B., Lynch, Iseult, Elia, Giuliano, Dawson, Kenneth·2011·ACS Nano
DOI 10.1021/nn202458g
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Abstract

The importance of the protein corona formed around nanoparticles upon entering a biological fluid has recently been highlighted. This corona is, when sufficiently long-lived, thought to govern the particles' biological fate. However, even this long-lived "hard" corona evolves and re-equilibrates as particles pass from one biological fluid to another, and may be an important feature for long-term fate. Here we show the evolution of the protein corona as a result of transfer of nanoparticles from one biological fluid (plasma) into another (cytosolic fluid), a simple illustrative model for the uptake of nanoparticles into cells. While no direct comparison can be made to what would happen in, for example, the uptake pathway, the results confirm that significant evolution of the corona occurs in the second biological solution, but that the final corona contains a "fingerprint" of its history. This could be evolved to map the transport pathways utilized by nanoparticles, and eventually to predict nanoparticle fate and behavior.

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Metadata

Authors
Lundqvist, M., Stigler, J., Cedervall, T., Berggård, T., Flanagan, M. B., Lynch, I., Elia, G., & Dawson, K.
Venue
ACS Nano
Publisher
American Chemical Society (ACS)
Published
2011-08-26
Volume
5
Issue
9
Pages
7503-7509
ISSN
  • 1936-0851
  • 1936-086X
DOI
10.1021/nn202458g
Cited by
752
References
1
Language
en

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