The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Hydrogel Containing Nanoparticle-Stabilized Liposomes for Topical Antimicrobial Delivery
Open accessAbstract
Adsorbing small charged nanoparticles onto the outer surfaces of liposomes has become an effective strategy to stabilize liposomes against fusion prior to "seeing" target bacteria, yet allow them to fuse with the bacteria upon arrival at the infection sites. As a result, nanoparticle-stabilized liposomes have become an emerging drug delivery platform for treatment of various bacterial infections. To facilitate the translation of this platform for clinical tests and uses, herein we integrate nanoparticle-stabilized liposomes with hydrogel technology for more effective and sustained topical drug delivery. The hydrogel formulation not only preserves the structural integrity of the nanoparticle-stabilized liposomes, but also allows for controllable viscoeleasticity and tunable liposome release rate. Using Staphylococcus aureus bacteria as a model pathogen, we demonstrate that the hydrogel formulation can effectively release nanoparticle-stabilized liposomes to the bacterial culture, which subsequently fuse with bacterial membrane in a pH-dependent manner. When topically applied onto mouse skin, the hydrogel formulation does not generate any observable skin toxicity within a 7-day treatment. Collectively, the hydrogel containing nanoparticle-stabilized liposomes hold great promise for topical applications against various microbial infections.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Recent advances with liposomes as pharmaceutical carriers
Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282
Hydrogels for biomedical applications
Hoffman, A. S. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00239-3 · Cited by 4,864
Nanoparticle therapeutics: an emerging treatment modality for cancer
Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233
Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology
Peppas, N. A., Hilt, J. Z., Khademhosseini, A., & Langer, R. (2006) · Advanced Materials · doi:10.1002/adma.200501612 · Cited by 4,109
Hydrogels for biomedical applications
Hoffman, A. S. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.010 · Cited by 3,396
Lipid nanoparticles for improved topical application of drugs for skin diseases☆
SCHAFERKORTING, M., MEHNERT, W., & KORTING, H. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.04.006 · Cited by 614
Haluska, C. K., Riske, K. A., Marchi-Artzner, V., Lehn, J.-M., Lipowsky, R., & Dimova, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602766103 · Cited by 240
Cited by
Li, T., Wang, P., Guo, W., Huang, X., Tian, X., Wu, G., Xu, B., Li, F., Yan, C., Liang, X.-J., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b01346 · Cited by 462
Nanoparticle-based local antimicrobial drug delivery
Gao, W., Chen, Y., Zhang, Y., Zhang, Q., & Zhang, L. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.09.015 · Cited by 396
Self-citationLiu, Y., Busscher, H. J., Zhao, B., Li, Y., Zhang, Z., van der Mei, H. C., Ren, Y., & Shi, L. (2016) · ACS Nano · doi:10.1021/acsnano.6b01370 · Cited by 379
Cai, K., He, X., Song, Z., Yin, Q., Zhang, Y., Uckun, F. M., Jiang, C., & Cheng, J. (2015) · Journal of the American Chemical Society · doi:10.1021/ja513034e · Cited by 363
Nanomedicine in the management of microbial infection – Overview and perspectives
Zhu, X., Radovic-Moreno, A. F., Wu, J., Langer, R., & Shi, J. (2014) · Nano Today · doi:10.1016/j.nantod.2014.06.003 · Cited by 362
Nanoparticle approaches against bacterial infections
Gao, W., Thamphiwatana, S., Angsantikul, P., & Zhang, L. (2014) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1282 · Cited by 347
Self-citationNanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery
Gao, W., Zhang, Y., Zhang, Q., & Zhang, L. (2016) · Annals of Biomedical Engineering · doi:10.1007/s10439-016-1583-9 · Cited by 346
Self-citationNanoparticle–hydrogel superstructures for biomedical applications
Jiang, Y., Krishnan, N., Heo, J., Fang, R. H., & Zhang, L. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.05.041 · Cited by 266
Self-citationLipid nanoparticle-mediated efficient delivery of CRISPR/Cas9 for tumor therapy
Zhang, L., Wang, P., Feng, Q., Wang, N., Chen, Z., Huang, Y., Zheng, W., & Jiang, X. (2017) · NPG Asia Materials · doi:10.1038/am.2017.185 · Cited by 218
Self-citationCoviello, T., Trotta, A. M., Marianecci, C., Carafa, M., Di Marzio, L., Rinaldi, F., Di Meo, C., Alhaique, F., & Matricardi, P. (2015) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2014.10.060 · Cited by 70
Garcia‐Hernandez, A., Lobato‐Calleros, C., Vernon‐Carter, E. J., Sosa‐Hernandez, E., & Alvarez‐Ramirez, J. (2017) · Journal of Applied Polymer Science · doi:10.1002/app.44517 · Cited by 22
Metadata
- Authors
- Gao, W., Vecchio, D., Li, J., Zhu, J., Zhang, Q., Fu, V., Li, J., Thamphiwatana, S., Lu, D., & Zhang, L.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2014-02-05
- Volume
- 8
- Issue
- 3
- Pages
- 2900-2907
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W1992158470
- Cited by
- 249
- References
- 7
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
