Effect of Costaria costata Fucoidan on Expression of Matrix Metalloproteinase-1 Promoter, mRNA, and Protein
Abstract
Fucoidans are sulfated fucosylated polymers from brown algae cell walls. We assessed the inhibitory effects of Costaria costata fucoidan on UVB-induced MMP-1 promoter, mRNA, and protein expression in vitro using the immortalized human keratinocyte (HaCaT) cell line. Pretreatment with fucoidan significantly inhibited MMP-1 protein expression compared to UVB irradiation alone. Fucoidan significantly reduced MMP-1 mRNA expression and inhibited UVB-induced MMP-1 promoter activity by 37.3%, 53.3%, and 58.5% at 0.01, 0.1, and 1 microg/mL, respectively, compared to UVB irradiation alone. C. costata fucoidan may be a potential therapeutic agent to prevent and treat skin photoaging.
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Fucoidans inhibited MMP-1 promoter activity and increased type I procollagen mRNA and protein expression.
“They inhibited significantly MMP-1 promoter activity and increased type I procollagen mRNA and protein expression.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [70]
Costaria costata fucoidan may be considered a potential agent for prevention and treatment of skin photoaging.
“It was concluded that Costaria costata fucoidan may be considered as a potential agent for the prevention and treatment of skin photoaging [68,69,70].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [70]
Fucoidans suppressed UVB-induced MMP-1 expression and inhibited ERK activity in human skin fibroblasts in a dose-dependent manner.
“Fucoidans suppressed the UVB induced MMP-1 expression and inhibited ERKs activity in human skin fibroblasts in a dose-dependent manner.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [70]
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- Authors
- Moon, H. J., Park, K. S., Ku, M. J., Lee, M. S., Jeong, S. H., Imbs, T. I., Zvyagintseva, T. N., Ermakova, S. P., & Lee, Y. H.
- Affiliations
- Yonsei University (KR)
- Institute of Natural Products for Health Promotion and Department of Preventive Medicine, College of Medicine, Kosin University, Busan, 602-702, Korea, Department of Laboratory Medicine, College of Medicine, Yonsei University, Seoul, 120-749, Korea, and Pacific Institute of Bioorganic Chemistry of Far East Branch of the Russian Academy of Sciences, Vladivostok-22, Russian Federation
- Corresponding author
- Lee, Yong Hwan
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 2009-10-06
- Volume
- 72
- Issue
- 10
- Pages
- 1731-1734
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2089696691
- Cited by
- 57
- References
- 39
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 8 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 2 · 2012: 5
- FWCI
- 5.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Natural Products (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- Costaria costata, fucoidan, MMP-1, UVB irradiation, photoaging, keratinocytes, brown algae polysaccharides, anti-aging agents
- MeSH terms
- Phaeophyceae, Cell Wall, Humans, Polysaccharides, Proteins, RNA, Messenger, Ultraviolet Rays, Skin Aging, Matrix Metalloproteinase 1
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