Fucoidan inhibits UVB-induced MMP-1 promoter expression and down regulation of type I procollagen synthesis in human skin fibroblasts
Abstract
UVB reduces type I procollagen levels and increases matrix metalloproteinases-1 (MMP-1) levels in human skin and plays a major role in the process of photoaging. We previously reported that fucoidan inhibits UVB-induced MMP-1 expression at the protein and mRNA levels in human skin fibroblasts (HS68). Yet, the effects of fucoidan on UVB-induced MMP-1 promoter activity and type I procollagen have not been investigated. In this study, we assessed the effects of fucoidan on the inhibition of MMP-1 promoter activity and on the increase of type I procollagen synthesis in human skin fibroblasts. Fucoidan treatment significantly inhibited MMP-1 promoter activity compared to UVB irradiation alone. Fucoidan treatment also increased type I procollagen mRNA and protein expression in a dose-dependent manner compared to the control. Our data indicate that fucoidan may prevent UVB-induced MMP-1 expression and inhibit down-regulation of type I procollagen synthesis. We suggest that fucoidan may be a potential therapeutic agent to prevent and treat skin photoaging.
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Fucoidans suppressed UVB-induced MMP-1 expression and inhibited ERK activity in human skin fibroblasts in a dose-dependent manner.
“Fucoidans suppressed the UVB induced MMP-1 expression and inhibited ERKs activity in human skin fibroblasts in a dose-dependent manner.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [68]
Costaria costata fucoidan may be considered a potential agent for prevention and treatment of skin photoaging.
“It was concluded that Costaria costata fucoidan may be considered as a potential agent for the prevention and treatment of skin photoaging [68,69,70].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [68]
Fucoidans inhibited MMP-1 promoter activity and increased type I procollagen mRNA and protein expression.
“They inhibited significantly MMP-1 promoter activity and increased type I procollagen mRNA and protein expression.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [68]
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- Authors
- Moon, H. J., Lee, S. H., Ku, M. J., Yu, B. C., Jeon, M. J., Jeong, S. H., Stonik, V. A., Zvyagintseva, T. N., Ermakova, S. P., & Lee, Y. H.
- Affiliations
- Kosin University (KR)
- Yonsei University (KR)
- ORCID
- Venue
- European Journal of Dermatology
- Publisher
- JLE
- Published
- 2009-03
- Volume
- 19
- Issue
- 2
- Pages
- 129-134
- ISSN
- 1167-1122 (ISSN-L)
- 1952-4013
- OpenAlex
- W2158597583
- Cited by
- 81
- References
- 29
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 6 · 2023: 7 · 2022: 3 · 2021: 9 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 2 · 2016: 6 · 2015: 5 · 2014: 7 · 2013: 3 · 2012: 4
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- fucoidan, UV-B radiation, MMP-1, type I procollagen, photoaging, dermal fibroblasts, collagen synthesis, marine polysaccharides
- MeSH terms
- Analysis of Variance, Cell Line, Cell Survival, Fibroblasts, Humans, Polysaccharides, RNA, Messenger, Ultraviolet Rays, Blotting, Western, Down-Regulation, Skin Aging, Reverse Transcriptase Polymerase Chain Reaction, Matrix Metalloproteinase 1, Collagen Type I
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