Cited by 81Skin Protection and AgingSeaweed-derived Bioactive CompoundsProtease and Inhibitor Mechanisms

Fucoidan inhibits UVB-induced MMP-1 promoter expression and down regulation of type I procollagen synthesis in human skin fibroblasts

Moon, Hee Jung, Lee, Sang Ho, Ku, Mi Jeong, Yu, Byeng Chul, Jeon, Man Joong, Jeong, Seok Hoon, Stonik, Valentin A, Zvyagintseva, Tatyana N +2 more·2009·European Journal of Dermatology

Abstract

UVB reduces type I procollagen levels and increases matrix metalloproteinases-1 (MMP-1) levels in human skin and plays a major role in the process of photoaging. We previously reported that fucoidan inhibits UVB-induced MMP-1 expression at the protein and mRNA levels in human skin fibroblasts (HS68). Yet, the effects of fucoidan on UVB-induced MMP-1 promoter activity and type I procollagen have not been investigated. In this study, we assessed the effects of fucoidan on the inhibition of MMP-1 promoter activity and on the increase of type I procollagen synthesis in human skin fibroblasts. Fucoidan treatment significantly inhibited MMP-1 promoter activity compared to UVB irradiation alone. Fucoidan treatment also increased type I procollagen mRNA and protein expression in a dose-dependent manner compared to the control. Our data indicate that fucoidan may prevent UVB-induced MMP-1 expression and inhibit down-regulation of type I procollagen synthesis. We suggest that fucoidan may be a potential therapeutic agent to prevent and treat skin photoaging.

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Crossref · 10.1684/ejd.2008.0611

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Authors
Moon, H. J., Lee, S. H., Ku, M. J., Yu, B. C., Jeon, M. J., Jeong, S. H., Stonik, V. A., Zvyagintseva, T. N., Ermakova, S. P., & Lee, Y. H.
Affiliations
  • Kosin University (KR)
  • Yonsei University (KR)
Venue
European Journal of Dermatology
Publisher
JLE
Published
2009-03
Volume
19
Issue
2
Pages
129-134
ISSN
  • 1167-1122 (ISSN-L)
  • 1952-4013
OpenAlex
W2158597583
Cited by
81
References
29
Citations by year
2026: 2 · 2025: 1 · 2024: 6 · 2023: 7 · 2022: 3 · 2021: 9 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 2 · 2016: 6 · 2015: 5 · 2014: 7 · 2013: 3 · 2012: 4
FWCI
4.56
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Dermatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Keywords
fucoidan, UV-B radiation, MMP-1, type I procollagen, photoaging, dermal fibroblasts, collagen synthesis, marine polysaccharides
MeSH terms
Analysis of Variance, Cell Line, Cell Survival, Fibroblasts, Humans, Polysaccharides, RNA, Messenger, Ultraviolet Rays, Blotting, Western, Down-Regulation, Skin Aging, Reverse Transcriptase Polymerase Chain Reaction, Matrix Metalloproteinase 1, Collagen Type I

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