Antitumor Active Fucoidan from the Brown Seaweed,Umitoranoo(Sargassum thunbergii)
Abstract
Neutral and acidic polysaccharides and their protein complexes were fractionated and purified from the brown seaweed umitoranoo (Sargassum thunbergii) by fractional extraction, iron-exchange chromatography, and gel filtration. Thirty-one polysaccharide fractions were obtained and tested for antitumor activity in mice with Ehrlich carcinoma transplanted i.p. Two of the fractions, GIV-A ([alpha]25D -127 degrees and mol. wt., 19,000) and GIV-B ([alpha]25D -110 degrees and mol. wt., 13,500) had such activity. On the basis of chemical and spectral analyses, these compounds were found to be a fucoidan or L-fucan containing approx. 30% sulfate ester groups per fucose residue, about 10% uronic acid, and less than 2% protein.
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- Authors
- Zhuang, C., Itoh, H., Mizuno, T., & Ito, H.
- Affiliations
- Shizuoka University (JP)
- Corresponding author
- Mizuno, Takashi
- Venue
- Bioscience, Biotechnology, and Biochemistry
- Publisher
- Informa UK Limited
- Published
- 1995-01
- Volume
- 59
- Issue
- 4
- Pages
- 563-567
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W2078942620
- Cited by
- 184
- References
- 0
- Citations by year
- 2025: 5 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 12 · 2018: 8 · 2017: 6 · 2016: 9 · 2015: 4 · 2014: 10 · 2013: 10 · 2012: 12
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioscience Biotechnology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
- Keywords
- fucoidan, Sargassum thunbergii, brown algae, anticancer activity, Ehrlich ascites carcinoma, polysaccharide fractionation, uronic acid, sulfated polysaccharides, marine natural products
- MeSH terms
- Animals, Antineoplastic Agents, Carcinoma, Ehrlich Tumor, Chromatography, Gel, Chromatography, Ion Exchange, Female, Mice, Inbred ICR, Neoplasm Transplantation, Magnetic Resonance Spectroscopy, Polysaccharides, Seaweed, Spectrophotometry, Infrared, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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