Cited by 184Seaweed-derived Bioactive CompoundsPolysaccharides Composition and ApplicationsPolysaccharides and Plant Cell Walls

Antitumor Active Fucoidan from the Brown Seaweed,Umitoranoo(Sargassum thunbergii)

Zhuang, Cun, Itoh, Hiroko, Mizuno, Takashi, Ito, Hitoshi·1995·Bioscience, Biotechnology, and Biochemistry

Abstract

Neutral and acidic polysaccharides and their protein complexes were fractionated and purified from the brown seaweed umitoranoo (Sargassum thunbergii) by fractional extraction, iron-exchange chromatography, and gel filtration. Thirty-one polysaccharide fractions were obtained and tested for antitumor activity in mice with Ehrlich carcinoma transplanted i.p. Two of the fractions, GIV-A ([alpha]25D -127 degrees and mol. wt., 19,000) and GIV-B ([alpha]25D -110 degrees and mol. wt., 13,500) had such activity. On the basis of chemical and spectral analyses, these compounds were found to be a fucoidan or L-fucan containing approx. 30% sulfate ester groups per fucose residue, about 10% uronic acid, and less than 2% protein.

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Crossref · 10.1271/bbb.59.563

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Authors
Zhuang, C., Itoh, H., Mizuno, T., & Ito, H.
Affiliations
Shizuoka University (JP)
Corresponding author
Mizuno, Takashi
Venue
Bioscience, Biotechnology, and Biochemistry
Published
1995-01
Volume
59
Issue
4
Pages
563-567
ISSN
  • 0916-8451 (ISSN-L)
  • 1347-6947
OpenAlex
W2078942620
Cited by
184
References
0
Citations by year
2025: 5 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 12 · 2018: 8 · 2017: 6 · 2016: 9 · 2015: 4 · 2014: 10 · 2013: 10 · 2012: 12
FWCI
1.46
Type
journal article
Language
en
Open access
closed
Locations
  • Bioscience Biotechnology and Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
Keywords
fucoidan, Sargassum thunbergii, brown algae, anticancer activity, Ehrlich ascites carcinoma, polysaccharide fractionation, uronic acid, sulfated polysaccharides, marine natural products
MeSH terms
Animals, Antineoplastic Agents, Carcinoma, Ehrlich Tumor, Chromatography, Gel, Chromatography, Ion Exchange, Female, Mice, Inbred ICR, Neoplasm Transplantation, Magnetic Resonance Spectroscopy, Polysaccharides, Seaweed, Spectrophotometry, Infrared, Mice

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