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Autonomic Nervous System Function in Women with Irritable Bowel Syndrome
Abstract
Autonomic nervous system (ANS) balance was assessed in women with and without irritable bowel syndrome (IBS) using laboratory tests of function (ie, expiratory/inspiratory ratio, Valsalva, posture changes, and cold pressor) and spectral and nonspectral measures of heart rate variability (HRV). Women with (N = 103) and without IBS (N = 49) were recruited, interviewed, then completed a laboratory assessment and wore a 24-hr Holter monitor Analysis using the entire sample showed little difference between IBS and control women and between subgroups with IBS on either laboratory measures or 24-hr HRV measures. However, analysis restricted to those women with severe IBS symptoms showed quite pronounced differences between two IBS subgroups on 24-hr HRV measures. Parasympathetic tone was significantly lower and ANS balance was significantly higher in the constipation-predominant compared to the diarrhea-predominant group. Subgroups of women with IBS do differ in ANS function as measured by 24-hr HRV; however, these differences are only apparent among women with severe symptoms. These findings point out the importance of considering symptom severity when interpreting studies of IBS.
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Nineteen studies compared IBS with HC, 9 compared IBD with HC, and 2 compared HRV across all 3 comparators.
“Nineteen studies compared IBS with HC (31–49), 9 compared IBD with HC (50–58), and 2 compared HRV across all 3 comparators (41,44).”
From Alterations in Heart Rate Variability Associated With Irritable Bowel Syndrome or Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis (2021) · cites this paper as [34]
HF was recorded in all studies, LF was recorded in 26 (96.8%), and VLF was recorded in 6 (21.4%).
“HF was recorded in all studies, LF was recorded in 26 (96.8%) (31–47,50–58), and VLF was recorded in 6 (21.4%) (37,41,44,52,56,57).”
From Alterations in Heart Rate Variability Associated With Irritable Bowel Syndrome or Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis (2021) · cites this paper as [34]
HF was recorded in all studies, LF was recorded in 26 (96.8%), and VLF was recorded in 6 (21.4%).
“HF was recorded in all studies, LF was recorded in 26 (96.8%) (31–47,50–58), and VLF was recorded in 6 (21.4%) (37,41,44,52,56,57).”
From Alterations in Heart Rate Variability Associated With Irritable Bowel Syndrome or Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis (2021) · cites this paper as [32]
Nineteen studies compared IBS with HC, 9 compared IBD with HC, and 2 compared HRV across all 3 comparators.
“Nineteen studies compared IBS with HC (31–49), 9 compared IBD with HC (50–58), and 2 compared HRV across all 3 comparators (41,44).”
From Alterations in Heart Rate Variability Associated With Irritable Bowel Syndrome or Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis (2021) · cites this paper as [32]
HRV is an objective, noninvasive biomarker that reflects current ANS function correlated with IBS symptoms.
“HRV is an objective, noninvasive biomarker that reflects current ANS function correlated with IBS symptoms.”
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Metadata
- Authors
- Heitkemper, M., Jarrett, M., Cain, K. C., Burr, R., Levy, R. L., Feld, A., & Hertig, V.
- Affiliations
- University of Washington (US)
- Venue
- Digestive Diseases and Sciences
- Published
- 2001-06
- Volume
- 46
- Issue
- 6
- Pages
- 1276-1284
- ISSN
- 0163-2116 (ISSN-L)
- 1573-2568
- OpenAlex
- W1504284992
- Cited by
- 145
- References
- 32
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 4 · 2015: 10 · 2014: 7 · 2013: 6 · 2012: 9
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Digestive Diseases and Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Nursing Research (NR04101)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- irritable bowel syndrome, autonomic nervous system, heart rate variability, parasympathetic activity, irritable bowel syndrome with constipation, diarrhea-predominant irritable bowel syndrome, symptom severity, women, 24-hour Holter monitoring, Valsalva maneuver, cold pressor test
- MeSH terms
- Adult, Autonomic Nervous System, Colonic Diseases, Functional, Female, Humans
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