How Useful Is Paracetamol Absorption as a Marker of Gastric Emptying? A Systematic Literature Study

Willems, Marleen; Quartero, A. Otto; Numans, Mattijs E.

doi:10.1023/a:1011935603893

Cited by 211Gastrointestinal motility and disordersGastrointestinal Bleeding Diagnosis and TreatmentEnhanced Recovery After Surgery

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

How Useful Is Paracetamol Absorption as a Marker of Gastric Emptying? A Systematic Literature Study

Willems, Marleen, Quartero, A. Otto, Numans, Mattijs E.·2001·Digestive Diseases and Sciences

DOI 10.1023/a:1011935603893

Open this paper in CoChat — free account

Abstract

Functional dyspepsia is a common disorder in primary care and gastroenterology units; however, the pathophysiology is poorly understood. Delayed gastric emptying is present in nearly 40% of patients. We evaluated the validity of the paracetamol absorption test in comparison with scintigraphy for gastric emptying assessment. Studies comparing scintigraphy with paracetamol absorption were selected through a structured Medline search. A correlation coefficient between scintigraphy and paracetamol absorption over 0.6 was considered good, between 0.45 and 0.6 intermediate, and below 0.45 poor. Feasibility was assessed by studying the administration of paracetamol, frequency of blood sampling, duration of the test period, and parameters used in the analysis. Thirteen studies were identified, eight (127 subjects) found a good correlation between scintigraphy and paracetamol absorption, two studies (28 subjects) found a moderate correlation, and three (25 subjects) found no correlation. Parameters used were area under the curve (N = 9), fixed-time concentrations (N = 6), concentration-max (N = 4) and time-to-concentration-max (N = 5). Repetitive blood samples ranged from 6 to 20 samples. The durations were 1.5-8 h. In conclusion, the paracetamol absorption technique generally correlates well to scintigraphy of liquid phase gastric emptying. The execution and outcome parameters however need further standardization to optimize its' value for clinical use and research purposes.

Integrity signals

Registry

Crossref · 10.1023/a:1011935603893

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Orally administered acetaminophen is poorly absorbed by the stomach but absorbed rapidly from the small intestine, so gastric emptying is the rate-limiting step for the appearance of acetaminophen in the blood.
“Orally administered acetaminophen is poorly absorbed by the stomach but absorbed rapidly from the small intestine. Thus, gastric emptying is the rate-limiting step for the appearance of acetaminophen in the blood.18”
From Effects of the once-daily GLP-1 analog liraglutide on gastric emptying, glycemic parameters, appetite and energy metabolism in obese, non-diabetic adults (2014) · cites this paper as [18]
Acetaminophen absorption is an indirect assessment of the liquid phase of gastric emptying.
“Acetaminophen absorption is an indirect assessment of the liquid phase of gastric emptying.”
From Effects of the once-daily GLP-1 analog liraglutide on gastric emptying, glycemic parameters, appetite and energy metabolism in obese, non-diabetic adults (2014) · cites this paper as [18]

The dependence of paracetamol absorption on the rate of gastric emptying
Heading, R. C., Nimmo, J., Prescott, L. F., & Tothill, P. (1973) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1973.tb08339.x · Cited by 569
Functional dyspepsia : a classification with guidelines for diagnosis and management
Talley, N. (1991) · Medical Entomology and Zoology · Cited by 435
Prevalence of symptoms of dyspepsia in the community.
Jones, R. H., & LYDEARD, S. (1989) · BMJ · doi:10.1136/bmj.298.6665.30 · Cited by 429
Kinetic Analysis of Blood Levels and Urinary Excretion in the Absorptive Phase after Single Doses of Drug
Wagner, J. G., & Nelson, E. (1964) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600531126 · Cited by 410
EFFECT OF GEL FIBRE ON GASTRIC EMPTYING AND ABSORPTION OF GLUCOSE AND PARACETAMOL
Holt, S., Carter, D., Tothill, P., Heading, R. C., & Prescott, L. F. (1979) · The Lancet · doi:10.1016/s0140-6736(79)91079-1 · Cited by 403
Kinetics of acetaminophen absorption and gastric emptying in man
Clements, J. A., Heading, R. C., Nimmo, W. S., & Prescott, L. F. (1978) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1978244420 · Cited by 369
Measurement of gastrointestinal motility in the GI laboratory
Camilleri, M., Hasler, W. L., Parkman, H. P., Quigley, E. M. M., & Soffer, E. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70155-6 · Cited by 347
Influence of gender and menopause on gastric emptying and motility
Hutson, W. R., Roehrkasse, R. L., & Wald, A. M. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)90758-0 · Cited by 304
Pharmacokinetics of paracetamol (acetaminophen) after intravenous and oral administration
Rawlins, M. D., Henderson, D. B., & Hijab, A. R. (1977) · European Journal of Clinical Pharmacology · doi:10.1007/bf00607678 · Cited by 284
Inhibition of gastric emptying and drug absorption by narcotic analgesics
Nimmo, W., Heading, R., Wilson, J., Tothill, P., & Prescott, L. (1975) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1975.tb00568.x · Cited by 269
Drugs, Diseases and Altered Gastric Emptying
Nimmo, W. S. (1976) · Clinical Pharmacokinetics · doi:10.2165/00003088-197601030-00002 · Cited by 215
Disturbed solid-phase gastric emptying in functional dyspepsia: a meta-analysis
Quarter, A. O., De Wit, N. J., Lodder, A. C., Numans, M. E., Smout, A. J. P. M., & Hoes, A. W. (1998) · Digestive Diseases and Sciences · doi:10.1023/a:1018803129779 · Cited by 209
Self-citation
Measurement of gastric emptying in dyspeptic patients: effect of a new gastrokinetic agent (cisapride).
Jian, R., Ducrot, F., Piedeloup, C., Mary, J. Y., Najean, Y., & Bernier, J. J. (1985) · Gut · doi:10.1136/gut.26.4.352 · Cited by 151
Geographical Differences in the Prevalence of Dyspepsia
Knill-Jones, R. P. (1991) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529109109532 · Cited by 149
Effect of the Menstrual Cycle on Gastric Emptying
Gill, R. C., Murphy, P. D., Hooper, H. R., Bowes, K. L., & Kingma, Y. J. (2009) · Digestion · doi:10.1159/000199414 · Cited by 129
Effect of age on gastric emptying of liquid-solid meals in man
Moore, J. G., Tweedy, C., Christian, P., & Datz, F. (1983) · Digestive Diseases and Sciences · doi:10.1007/bf01324951 · Cited by 125
What is behind dyspepsia?
Klauser, A. G., Voderholzer, W. A., Knesewitsch, P., Schindlbeck, N. E., & M�ller-Lissner, S. A. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01296788 · Cited by 124
Gastroduodenal motility and dysmotility: an update on techniques available for evaluation.
Parkman, H. P., Harris, A. D., Krevsky, B., Urbain, J. L., Maurer, A. H., & Fisher, R. S. (1995) · PubMed · Cited by 105
Inter‐ and intrasubject variability of gastric emptying in healthy volunteers measured by scintigraphy and paracetamol absorption.
Petring, O., & Flachs, H. (1990) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1990.tb03691.x · Cited by 89
The normal menstrual cycle has no effect on gastric emptying
Horowitz, M., Maddern, G. J., Chatterton, B. E., Collins, P., Petrucco, O. M., Seamark, R. F., & Shearman, D. J. C. (1985) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1985.tb01458.x · Cited by 88
The influence of levodopa on gastric emptying in man.
Robertson, D., Renwick, A., Wood, N., Cross, N. C. P., Macklin, B., Fleming, J. S., Waller, D., & George, C. (1990) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1990.tb03601.x · Cited by 73
Methods to study gastric emptying
Vantrappen, G. R. (1994) · Digestive Diseases and Sciences · doi:10.1007/bf02300381 · Cited by 69
Delay of gastric emptying by duodenal intubation: sensitive measurement of gastric emptying by the paracetamol absorption test
Medhus, Sandstad, BREDESEN, & Husebye (1999) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1999.00519.x · Cited by 65
Guide for judicious use of the paracetamol absorption technique in a study of gastric emptying rate of liquids
Sanaka, M., Kuyama, Y., & Yamanaka, M. (1998) · Journal of Gastroenterology · doi:10.1007/s005350050177 · Cited by 64
Disorders of gastric emptying in humans and the use of radionuclide techniques.
Horowitz, M., Collins, P., & Shearman, D. (1985) · Archives of Internal Medicine · doi:10.1001/archinte.1985.00360080145022 · Cited by 58
Effect of intravenous atropine on gastric emptying, paracetamol absorption, salivary flow and heart rate in young and fit elderly volunteers.
Rashid, M., & Bateman, D. N. (1990) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1990.tb03739.x · Cited by 51
THE INFLUENCE OF POSTURE ON PARACETAMOL ABSORPTION
Nimmo, W. S., & Prescott, L. F. (1978) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1978.tb01721.x · Cited by 49
The influence of levodopa on gastric emptying in healthy elderly volunteers
Robertson, D. R. C., Renwick, A. G., Macklin, B., Jones, S., Waller, D. G., George, C. F., & Fleming, J. S. (1992) · European Journal of Clinical Pharmacology · doi:10.1007/bf00280127 · Cited by 45
Acetaminophen absorption and metabolism in celiac disease and Crohn's disease
Holt, S., Heading, R. C., Clements, J. A., Tothill, P., & Prescott, L. F. (1981) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1981.153 · Cited by 37
LIQUID GASTRIC EMPTYING ASSESSED BY DIRECT AND INDIRECT TECHNIQUES: RADIONUCLIDE LABELLED LIQUID EMPTYING COMPARED WITH A SIMPLE PARACETAMOL MARKER METHOD
Maddern, G. J., Miners, J. O., Collins, P., & Jamieson, G. G. (1985) · Australian and New Zealand Journal of Surgery · doi:10.1111/j.1445-2197.1985.tb00885.x · Cited by 36
The relationship between gastric emptying of semisolids and paracetamol absorption.
Petring, O., Adelhøj, B., Ibsen, M., & Poulsen, H. E. (1986) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1986.tb02954.x · Cited by 36
Methods to study gastric emptying
Smout, A. J. P. M., Horowitz, M., & Armstrong, D. (1994) · Digestive Diseases and Sciences · doi:10.1007/bf02300393 · Cited by 31
A reliable and convenient parameter of the rate of paracetamol absorption to measure gastric emptying rate of liquids.
Sanaka, M., Koike, Y., Yamamoto, T., Mineshita, S., Yamaoka, S., Hirama, S., Tanaka, H., Kuyama, Y., & Yamanaka, M. (1997) · PubMed · Cited by 28
Intraindividual variability of paracetamol absorption kinetics after a semi-solid meal in healthy volunteers
Paintaud, G., Thibault, P., Queneau, P., Magnette, J., Bérard, M., Rumbach, L., Bechtel, P. R., & Carayon, P. (1998) · European Journal of Clinical Pharmacology · doi:10.1007/s002280050393 · Cited by 20
Gastric emptying in healthy volunteers after multiple doses of levodopa
Waller, D., Roseveare, C., Renwick, A., Macklin, B., & George, C. (1991) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1991.tb03975.x · Cited by 17
The mean cumulative fraction absorbed-time profiles of paracetamol as an index of gastric emptying.
van Wyk, M., Sommers, D., Ec, M., & Moncrieff, J. (1990) · PubMed · Cited by 17
Plasma paracetamol concentrations measured by fluorescence polarization immunoassay and gastric emptying time.
Koizumi, F., Kawamura, T., ISHIMORI, A., EBINA, H., & Satoh, M. (1988) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.155.159 · Cited by 15
Relationship between fractional calcium absorption and gastric emptying
Wishart, J., Horowitz, M., Morris, H. A., Need, A. G., Russo, A., Jones, K. L., Sun, W. M., & Nordin, B. E. C. (1995) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1995.tb01536.x · Cited by 14
The effects of co‐administration of benzhexol on the peripheral pharmacokinetics of oral levodopa in young volunteers
ROBERTS, J., Waller, D. G., RENWICK, A. G., O'Shea, N., Macklin, B., & Bulling, M. T. (1996) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1996.32311.x · Cited by 13
THE PROPORTIONAL CUMULATIVE AREA UNDER THE CURVE OF PARACETAMOL USED AS AN INDEX OF GASTRIC EMPTYING IN DIABETIC PATIENTS WITH SYMPTOMS OF GASTROPARESIS
van Wyk, M., Sommers, D. K., Snyman, J. R., & Moncrieff, J. (1995) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1995.tb02080.x · Cited by 8
Gastric Emptying of Semi-Solid Meal in Normal Man with Special Reference to Relationship between Plasma Acetoaminophen Concentrations and Gastric Emptying Time.
Koyama, K., Sasaki, I., Naito, H., Tsuchiya, T., Funayama, Y., Shibata, C., Ohtani, N., Matsuno, S., & Maruoka, S. (1995) · Journal of Smooth Muscle Research · doi:10.1540/jsmr.31.61 · Cited by 7

Flagged first, then by citations

Research works printed but not linked: 1

Heading RC, Bolondi L, Camilleri M, Corinaldesi R, Horowitz M, Jian R, Scarpignato R: Gastric emptying. Gastroenterol Int 5(4):203–215, 1992

Sorted by citations

Effects of the once-daily GLP-1 analog liraglutide on gastric emptying, glycemic parameters, appetite and energy metabolism in obese, non-diabetic adults
van Can, J., Sloth, B., Jensen, C. B., Flint, A., Blaak, E. E., & Saris, W. H. M. (2014) · International Journal of Obesity · doi:10.1038/ijo.2013.162 · Cited by 537
A methodological review of how heterogeneity has been examined in systematic reviews of diagnostic test accuracy
Dinnes, J., Deeks, J. J., Kirby, J., & Roderick, P. J. (2005) · Health Technology Assessment · doi:10.3310/hta9120 · Cited by 440
The effect of semaglutide 2.4 mg once weekly on energy intake, appetite, control of eating, and gastric emptying in adults with obesity
Friedrichsen, M., Breitschaft, A., Tadayon, S., Wizert, A., & Skovgaard, D. (2021) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.14280 · Cited by 427
Viscosity of Oat Bran-Enriched Beverages Influences Gastrointestinal Hormonal Responses in Healthy Humans
Juvonen, K. R., Purhonen, A., Salmenkallio‐Marttila, M., Lähteenmäki, L., Laaksonen, D. E., Herzig, K., Uusitupa, M. I. J., Poutanen, K. S., & Karhunen, L. J. (2009) · Journal of Nutrition · doi:10.3945/jn.108.099945 · Cited by 264
Semaglutide improves postprandial glucose and lipid metabolism, and delays first‐hour gastric emptying in subjects with obesity
Hjerpsted, J. B., Flint, A., Brooks, A., Axelsen, M. B., Kvist, T., & Blundell, J. (2018) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13120 · Cited by 245
Effect of a high-protein breakfast on the postprandial ghrelin response
Blom, W. A. M., Lluch, A., Stafleu, A., Vinoy, S., Holst, J. J., Schaafsma, G., & Hendriks, H. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.211 · Cited by 242
Endogenous Glucagon-Like Peptide-1 Slows Gastric Emptying in Healthy Subjects, Attenuating Postprandial Glycemia
Deane, A. M., Nguyen, N. Q., Stevens, J. E., Fraser, R. J., Holloway, R. H., Besanko, L. K., Burgstad, C. M., Jones, K. L., Chapman, M. J., Rayner, C. K., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1503 · Cited by 240
Impaired regulation of the incretin effect in patients with type 2 diabetes
Bagger, J. I., Knop, F. K., Lund, A., Vestergaard, H., Holst, J. J., & Vilsbøll, T. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2435 · Cited by 219
Liraglutide in Type 2 Diabetes Mellitus: Clinical Pharmacokinetics and Pharmacodynamics
Jacobsen, L. V., Flint, A., Olsen, A. K., & Ingwersen, S. H. (2016) · Clinical Pharmacokinetics · doi:10.1007/s40262-015-0343-6 · Cited by 217
Semaglutide, delayed gastric emptying, and intraoperative pulmonary aspiration: a case report
Klein, S. R., & Hobai, I. A. (2023) · Canadian Journal of Anesthesia/Journal canadien d'anesthésie · doi:10.1007/s12630-023-02440-3 · Cited by 207
The effect of exogenous GLP-1 on food intake is lost in male truncally vagotomized subjects with pyloroplasty
Plamboeck, A., Veedfald, S., Deacon, C. F., Hartmann, B., Wettergren, A., Svendsen, L. B., Meisner, S., Hovendal, C. P., Vilsbøll, T., Knop, F. K., et al. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00035.2013 · Cited by 188
Biowaiver monographs for immediate release solid oral dosage forms: Acetaminophen (paracetamol)
Kalantzi, L., Reppas, C. I., Dressman, J., Amidon, G. L., Junginger, H. E., Midha, K. K., Shah, V. P., Stavchansky, S., & Barends, D. M. (2005) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20477 · Cited by 182
Effect of the once-daily human GLP-1 analogue liraglutide on appetite, energy intake, energy expenditure and gastric emptying in type 2 diabetes
Horowitz, M., Flint, A., Jones, K. L., Hindsberger, C., Rasmussen, M. F., Kapitza, C., Doran, S., Jax, T., Zdravkovic, M., & Chapman, I. M. (2012) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2012.02.016 · Cited by 179
Exogenous Glucose–Dependent Insulinotropic Polypeptide Worsens Post prandial Hyperglycemia in T ype 2 Diabetes
Chia, C. W., Carlson, O. D., Kim, W., Shin, Y., Charles, C. P., Kim, H. S., Melvin, D. L., & Egan, J. M. (2009) · Diabetes · doi:10.2337/db08-0958 · Cited by 174
Pre‐operative carbohydrate loading may be used in type 2 diabetes patients
Gustafsson, U. O., Nygren, J., Thorell, A., Soop, M., Hellström, P. M., Ljungqvist, O. H., & Toft, E. (2008) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2008.01599.x · Cited by 171
Gastrointestinal targets of appetite regulation in humans
Delzenne, N. M., Blundell, J. E., Brouns, F. J. P. H., Cunningham, K., de Graaf, K. C., Erkner, A., Lluch, A., Mars, M., Peters, H. P. F., & Westerterp‐Plantenga, M. S. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00707.x · Cited by 172
Breakfast Consumption Affects Appetite, Energy Intake, and the Metabolic and Endocrine Responses to Foods Consumed Later in the Day in Male Habitual Breakfast Eaters
Astbury, N. M., Taylor, M. A., & Macdonald, I. A. (2011) · Journal of Nutrition · doi:10.3945/jn.110.128645 · Cited by 156
Liraglutide suppresses postprandial triglyceride and apolipoprotein B48 elevations after a fat‐rich meal in patients with type 2 diabetes: a randomized, double‐blind, placebo‐controlled, cross‐over trial
Hermansen, K., Bækdal, T. A., Düring, M., Pietraszek, A., Mortensen, L. S., Jørgensen, H., & Flint, A. (2013) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12133 · Cited by 143
Mechanism of action of pre-meal consumption of whey protein on glycemic control in young adults
Akhavan, T., Luhovyy, B. L., Panahi, S., Kubant, R., Brown, P. H., & Anderson, G. H. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.08.012 · Cited by 132
Altered GI Motility in Critically Ill Patients
Ukleja, A. (2010) · Nutrition in Clinical Practice · doi:10.1177/0884533609357568 · Cited by 127
Effect of liquid volume and food intake on the absolute bioavailability of danazol, a poorly soluble drug
Sunesen, V. H., Vedelsdal, R., Kristensen, H. G., Christrup, L. L., & Müllertz, A. (2005) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2004.11.005 · Cited by 119
Distinct Neural Sites of GLP-1R Expression Mediate Physiological versus Pharmacological Control of Incretin Action
Varin, E. M., Mulvihill, E. E., Baggio, L. L., Koehler, J. A., Cao, X., Seeley, R. J., & Drucker, D. J. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.055 · Cited by 104
Diacylglycerol acyltransferase 1 inhibition with AZD7687 alters lipid handling and hormone secretion in the gut with intolerable side effects: a randomized clinical trial
Denison, H., Nilsson, C., Löfgren, L., Himmelmann, A., Mårtensson, G., Knutsson, M., AL‐Shurbaji, A., Tornqvist, H., & Eriksson, J. W. (2014) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12221 · Cited by 104
Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities
Hens, B., Corsetti, M., Spiller, R. E., Marciani, L., Vanuytsel, T., Tack, J. F., Talattof, A., Amidon, G. L., Koziolek, M., Weitschies, W., et al. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.11.063 · Cited by 104
Effects of fat supplementation on glycaemic response and gastric emptying in adolescents with Type 1 diabetes
Lodefalk, M., Åman, J., & Bang, P. (2008) · Diabetic Medicine · doi:10.1111/j.1464-5491.2008.02530.x · Cited by 96
Drug-Drug Interactions Between Glucagon-Like Peptide 1 Receptor Agonists and Oral Medications: A Systematic Review
Calvarysky, B., Dotan, I., Shepshelovich, D., Leader, A., & Cohen, T. D. (2024) · Drug Safety · doi:10.1007/s40264-023-01392-3 · Cited by 97
The once-daily human glucagon-like peptide-1 (GLP-1) analog liraglutide improves postprandial glucose levels in type 2 diabetes patients
Flint, A., Kapitza, C., Hindsberger, C., & Zdravkovic, M. (2011) · Advances in Therapy · doi:10.1007/s12325-010-0110-x · Cited by 91
Diabetic and nondiabetic patients with nonalcoholic fatty liver disease have an impaired incretin effect and fasting hyperglucagonaemia
Junker, A. E., Gluud, L. L., Holst, J. J., Knop, F. K., & Vilsbøll, T. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12462 · Cited by 86
Oral semaglutide improves postprandial glucose and lipid metabolism, and delays gastric emptying, in subjects with type 2 diabetes
Dahl, K., Brooks, A., Almazedi, F., Hoff, S. T., Boschini, C., & Bækdal, T. A. (2021) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.14373 · Cited by 87
Sleeve gastrectomy effects on hunger, satiation, and gastrointestinal hormone and motility responses after a liquid meal test
Mans, E., Serra‐Prat, M., Palomera, E., Suñol, X., & Clavé, P. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.104307 · Cited by 85
LEAP2 reduces postprandial glucose excursions and ad libitum food intake in healthy men
Hagemann, C. A., Jensen, M. S., Holm, S., Gasbjerg, L. S., Byberg, S., Skov-Jeppesen, K., Hartmann, B., Holst, J. J., Dela, F., Vilsbøll, T., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100582 · Cited by 81
The acute impact of ingestion of breads of varying composition on blood glucose, insulin and incretins following first and second meals
Mofidi, A., Parsons, P. M., Duncan, A. M., Robinson, L. E., Yada, R. Y., & Graham, T. E. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508003085 · Cited by 80
Ultrasound assessment of gastric volume in critically ill patients
Hamada, S., Garçon, P., Ronot, M., Kerever, S., Paugam‐Burtz, C., & Mantz, J. (2014) · Intensive Care Medicine · doi:10.1007/s00134-014-3320-x · Cited by 78
Acetaminophen (Paracetamol) Oral Absorption and Clinical Influences
Raffa, R. B., Pergolizzi, J. V., Taylor, R., Decker, J. F., & Patrick, J. T. (2013) · Pain Practice · doi:10.1111/papr.12130 · Cited by 70
Randomised Controlled Trial Comparing Oral and Intravenous Paracetamol (Acetaminophen) Plasma Levels when given as Preoperative Analgesia
Westhuizen, J. V. D., Kuo, P.-Y., Reed, P., & Holder, K. (2011) · Anaesthesia and Intensive Care · doi:10.1177/0310057x1103900214 · Cited by 65
Acute Effect of Alginate‐Based Preload on Satiety Feelings, Energy Intake, and Gastric Emptying Rate in Healthy Subjects
Georg, M. G., Kristensen, M., Belza, A., Knudsen, J. C., & Astrup, A. V. (2011) · Obesity · doi:10.1038/oby.2011.232 · Cited by 62
Gastrointestinal peptides, gastrointestinal motility, and anorexia of aging in frail elderly persons
Serra-Prat, M., Mans, E., Palomera, E., & Clavé, P. (2013) · Neurogastroenterology and Motility · doi:10.1111/nmo.12055 · Cited by 58
Postprandial renal haemodynamic effect of lixisenatide vs once‐daily insulin‐glulisine in patients with type 2 diabetes on insulin‐glargine: An 8‐week, randomised, open‐label trial
Tonneijck, L., Muskiet, M. H. A., Smits, M. M., Hoekstra, T., Kramer, M. H. H., Danser, A. H. J., Diamant, M., Joles, J. A., & van Raalte, D. H. (2017) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12985 · Cited by 62
Methods for the Assessment of Gastric Emptying in Critically Ill, Enterally Fed Adults
Moreira, T. V., & McQuiggan, M. M. (2009) · Nutrition in Clinical Practice · doi:10.1177/0884533609332176 · Cited by 61
Effect of Semaglutide on the Pharmacokinetics of Metformin, Warfarin, Atorvastatin and Digoxin in Healthy Subjects
Hausner, H., Derving Karsbøl, J., Holst, A. G., Jacobsen, J. B., Wagner, F.-D., Golor, G., & Anderson, T. W. (2017) · Clinical Pharmacokinetics · doi:10.1007/s40262-017-0532-6 · Cited by 62
Characterisation of oral and i.v. glucose handling in truncally vagotomised subjects with pyloroplasty
Plamboeck, A., Veedfald, S., Deacon, C. F., Hartmann, B., Wettergren, A., Svendsen, L. B., Meisner, S., Hovendal, C. P., Knop, F. K., Vilsbøll, T., et al. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0264 · Cited by 59
Investigation of mechanisms involved in postprandial glycemia and insulinemia attenuation with dietary fibre consumption
Repin, N. V., Kay, B. A., Cui, S. W., Wright, A. J., Duncan, A. M., & Goff, H. D. (2017) · Food & Function · doi:10.1039/c7fo00331e · Cited by 58
Gastric Sensory and Motor Functions and Energy Intake in Health and Obesity—Therapeutic Implications
Cifuentes, L., Camilleri, M., & Acosta, A. J. (2021) · Nutrients · doi:10.3390/nu13041158 · Cited by 61
Effects of gastric emptying on the postprandial ghrelin response
Blom, W. A. M., Lluch, A., Vinoy, S., Stafleu, A., van den Berg, R., Holst, J. J., Kok, F. J., & Hendriks, H. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00238.2005 · Cited by 52
Effects of liraglutide on gallbladder emptying: A randomized, placebo‐controlled trial in adults with overweight or obesity
Nexøe‐Larsen, C. C., Sørensen, P. H., Hausner, H., Agersnap, M., Baekdal, M., Brønden, A., Gustafsson, L. N., Sonne, D. P., Vedtofte, L., Vilsbøll, T., et al. (2018) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13420 · Cited by 51
Lixisenatide reduces postprandial hyperglycaemia via gastrostatic and insulinotropic effects
Becker, R. H. A., Stechl, J., Steinstraesser, A., Golor, G., & Pellissier, F. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2647 · Cited by 50
Mechanism of action of whole milk and its components on glycemic control in healthy young men
Panahi, S., Khoury, D. T. D. E., Kubant, R., Akhavan, T., Luhovyy, B. L., Goff, H. D., & Anderson, G. H. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.07.002 · Cited by 47
Effect of meal size and texture on gastric pouch emptying and glucagon-like peptide 1 after gastric bypass surgery
Stano, S., Alam, F., Wu, L., Dutia, R., Ng, S.-N., Sala, M., McGinty, J., & Laferrère, B. (2017) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2017.09.004 · Cited by 46
Gastric emptying: a comparison of three methods
Glerup, H., Bluhme, H., Villadsen, G. E., Rasmussen, K., Ejskjær, N., & Dahlerup, J. F. (2007) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520701370922 · Cited by 45
Does adding milk to tea delay gastric emptying?
Hillyard, S., Cowman, S. A., Ramasundaram, R., Seed, P. T., & O’Sullivan, G. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aet261 · Cited by 44
Diabetic gastroparesis: An overview of pathogenesis, clinical presentation and novel therapies, with a focus on ghrelin receptor agonists
Petri, M., Singh, I., Baker, C., Underkofler, C., & Rasouli, N. (2021) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2020.107733 · Cited by 50
Paracetamol as a Post Prandial Marker for Gastric Emptying, A Food-Drug Interaction on Absorption
Bartholomé, R., Salden, B. N., Vrolijk, M. F., Troost, F. J., Masclee, A., Bast, A., & Haenen, G. R. M. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136618 · Cited by 43
Diabetic Gastroparesis and Its Impact on Glycemia
Chang, J., Rayner, C. K., Jones, K. L., & Horowitz, M. (2010) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2010.08.007 · Cited by 43
Effect of Colonic Lactulose Availability on the Timing of Drug Release Onset in Vivo from a Unique Colon-Specific Drug Delivery System (CODES™)
Yang, L., Watanabe, S., Li, J., Chu, J. S., Katsuma, M., Yokohama, S., & Fix, J. A. (2003) · Pharmaceutical Research · doi:10.1023/a:1022660305931 · Cited by 42
Diabetic gastroparesis—Backwards and forwards
Chang, J., Rayner, C. K., Jones, K. L., & Horowitz, M. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06573.x · Cited by 40
Gastric Dysmotility in Critically Ill Children
Martinez, E. E., Douglas, K., Nurko, S., & Mehta, N. M. (2015) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000000493 · Cited by 40
The Effect of Gastrostomy Placement on Gastric Function in Children: a Prospective Cohort Study
Franken, J., Mauritz, F. A., Stellato, R. K., van der Zee, D. C., & Lindeboom, M. Y. A. (2017) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-017-3376-3 · Cited by 38
The effect of the once-daily human glucagon-like peptide 1 analog liraglutide on the pharmacokinetics of acetaminophen
Kapitza, C., Zdravkovic, M., Hindsberger, C., & Flint, A. (2011) · Advances in Therapy · doi:10.1007/s12325-011-0044-y · Cited by 36
Perioperative management of patients on glucagon-like peptide-1 receptor agonists
Mizubuti, G. B., Ho, A. M. ‐., da Silva, L. M., & Phelan, R. (2024) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000001348 · Cited by 42
Dyspepsia and gastric emptying in end-stage renal disease patients on hemodialysis
Salles, L. D., Santos, P. R., dos Santos, A. A., & de Souza, M. H. L. P. (2013) · BMC Nephrology · doi:10.1186/1471-2369-14-275 · Cited by 36
Pharmacokinetics of Paracetamol in Göttingen Minipigs: In Vivo Studies and Modeling to Elucidate Physiological Determinants of Absorption
Suenderhauf, C., Tuffin, G., Lorentsen, H., Grimm, H.-P., Flament, C., & Parrott, N. J. (2014) · Pharmaceutical Research · doi:10.1007/s11095-014-1367-6 · Cited by 37
Gastric Emptying of Orally Administered Glucose Solutions and Incretin Hormone Responses Are Unaffected by Laparoscopic Adjustable Gastric Banding
Usinger, L., Hansen, K. B., Kristiansen, V. B., Larsen, S., Holst, J. J., & Knop, F. K. (2011) · Obesity Surgery · doi:10.1007/s11695-011-0362-9 · Cited by 33
The delayed dissolution of paracetamol products in the canine fed stomach can be predicted in vitro but it does not affect the onset of plasma levels
Kalantzi, L., Polentarutti, B. I., Albery, T., LAITMER, D., Abrahamsson, B., Dressman, J., & Reppas, C. I. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.02.028 · Cited by 33
Bioavailability of Orally Administered Drugs in Critically Ill Patients
Forsberg, J., Bedard, E. L. R., & Mahmoud, S. H. (2022) · Journal of Pharmacy Practice · doi:10.1177/08971900221100205 · Cited by 31
Does neostigmine increase gastric emptying in the critically ill?--results of a pilot study.
Lucey, M., Patil, V., Girling, K., Jacques, T., & O'Leary, M. (2003) · Critical Care and Resuscitation · doi:10.1016/s1441-2772(23)01213-9 · Cited by 30
Postprandial Hypoglycemia in Children after Gastric Surgery: Clinical Characterization and Pathophysiology
Calabria, A. C., Charles, L., Givler, S., & León, D. D. D. (2015) · Hormone Research in Paediatrics · doi:10.1159/000442155 · Cited by 30
Gastroparesis: The Complex Interplay with Microbiota and the Role of Exogenous Infections in the Pathogenesis of the Disease
Mandarino, F. V., Sinagra, E., Barchi, A., Verga, M. C., Brinch, D., Raimondo, D., & Danese, S. (2023) · Microorganisms · doi:10.3390/microorganisms11051122 · Cited by 29
Methods to assess gastric motility and sensation
Schmidt, P. T., Abrahamsson, H., Dolk, A., Hausken, T., Karling, P., Lindberg, G., Nyhlin, H., Ohlsson, B., Simrén, M., Sjölund, K., et al. (2008) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520802240263 · Cited by 30
Precision medicine for obesity: current evidence and insights for personalization of obesity pharmacotherapy
Añazco, D., & Acosta, A. J. (2024) · International Journal of Obesity · doi:10.1038/s41366-024-01599-z · Cited by 35
Xenin-25 delays gastric emptying and reduces postprandial glucose levels in humans with and without Type 2 diabetes
Chowdhury, S., Reeds, D. N., Crimmins, D. L., Patterson, B. W., Laciny, E., Wang, S., Tran, H. D., Griest, T. A., Rometo, D. A., Dunai, J., et al. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00383.2013 · Cited by 28
The influence of opioids on gastric function: experimental and clinical studies
Walldén, J. (2008) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2008.01773.x · Cited by 28
Effects of active commuting and leisure-time exercise on appetite in individuals with overweight and obesity
Quist, J. S., Blond, M. B., Gram, A. S., Steenholt, C. B., Janus, C., Holst, J. J., Rehfeld, J. F., Sjödin, A. M., Stallknecht, B. M., & Rosenkilde, M. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00239.2018 · Cited by 28
Pharmacokinetics of Mycophenolic Acid and Metabolites in Diabetic Kidney Transplant Recipients
Akhlaghi, F., Patel, C. G., Zuniga, X. P., Halilovic, J., Preis, I. S., & Gohh, R. (2006) · Therapeutic Drug Monitoring · doi:10.1097/01.ftd.0000189898.23931.3f · Cited by 28
Characteristics of Acetaminophen Absorption in Healthy Unweaned Calves as an Indirect Measurement of the Oroduodenal Transit Rate of Liquid Meals
Schaer, S., Herrli‐Gygi, M., Kosmeas, N., Boschung, H., & Steiner, A. C. (2005) · Zentralblatt für Veterinärmedizin Reihe A · doi:10.1111/j.1439-0442.2005.00738.x · Cited by 28
Integration of advanced methods and models to study drug absorption and related processes: An UNGAP perspective
WILSON, C. G., Aarons, L. J., Augustijns, P., Brouwers, J., Darwich, A. S., de Waal, T., Garbacz, G., Hansmann, S., Hoc, D., Ivanova, A., et al. (2021) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2021.106100 · Cited by 30
Evaluation of in vivo dissolution behavior and GI transit of griseofulvin, a BCS class II drug
Fujioka, Y., Metsugi, Y., Ogawara, K., Higaki, K., & Kimura, T. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.10.008 · Cited by 26
Gastric Emptying of Low- and High-Caloric Liquid Meals Measured Using Ultrasonography in Healthy Volunteers
Mazzawi, T. R. E., Bartsch, E., Benammi, S., Ferro, R., Nikitina, E., Nimer, N., Ortega, L., Perrotte, C., Pithon, J., Rosalina, S., et al. (2019) · Ultrasound International Open · doi:10.1055/a-0783-2170 · Cited by 25
Digestive Responses to Fortified Cow or Goat Dairy Drinks: A Randomised Controlled Trial
Milan, A. M., Hodgkinson, A. J., Mitchell, S. M., Prodhan, U. K., Prosser, C. G., Carpenter, E. A., Fraser, K., & Cameron‐Smith, D. (2018) · Nutrients · doi:10.3390/nu10101492 · Cited by 23
Integrative and quantitative bioenergetics: Design of a study to assess the impact of the gut microbiome on host energy balance
Corbin, K. D., Krajmalnik‐Brown, R., Carnero, E. Á., Bock, C., Emerson, R., Rittmann, B. E., Marcus, A. K., Davis, T. L., Dirks, B., Ilhan, Z. E., et al. (2020) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2020.100646 · Cited by 21
Transcutaneous fluorescence spectroscopy as a tool for non-invasive monitoring of gut function: first clinical experiences
Maurice, J. B., Lett, A. M., Skinner, C., Lim, A., Richardson, M., Thomas, A. P., Summers, P. A., Vyas, K., Tadbier, W., Vilar, R., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-73149-2 · Cited by 22
Cholecystokinin regulates satiation independently of the abdominal vagal nerve in a pig model of total subdiaphragmatic vagotomy
Ripken, D., van der Wielen, N., van der Meulen, J., Schuurman, T., Witkamp, R. F., Hendriks, H., & Koopmans, S. J. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.11.031 · Cited by 23
Effect of preoperative feeding on gastric emptying following spinal anesthesia: a randomized controlled trial
Protić, A., Turina, D., Matanić, D., Španjol, J., Žuvić-Butorac, M., & Šustić, A. (2010) · Wiener klinische Wochenschrift · doi:10.1007/s00508-009-1301-9 · Cited by 22
Delayed Gastric Emptying and Gastric Remnant Function After Pancreaticoduodenectomy: A Systematic Review of Objective Assessment Modalities
Wang, T. H., Lin, A. Y., Mentor, K., O’Grady, G., & Pandanaboyana, S. (2022) · World Journal of Surgery · doi:10.1007/s00268-022-06784-7 · Cited by 22
Effects of percutaneous endoscopic gastrostomy tube placement on gastric antral motility and gastric emptying
Ono, H., Azuma, T., Miyaji, H., Ito, S., Ohtaki, H., Ohtani, M., Dojo, M., Yamazaki, Y., & Kuriyama, M. (2003) · Journal of Gastroenterology · doi:10.1007/s00535-003-1174-z · Cited by 22
Frequency of Aspirating Gastric Tubes for Patients Receiving Enteral Nutrition in the ICU
Williams, T. A., Leslie, G. D., Mills, L., Leen, T., Davies, H. T., Hendron, D., & DOBB, G. J. (2013) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607113497223 · Cited by 21
Mechanism‐Based Modeling of Gastric Emptying Rate and Gallbladder Emptying in Response to Caloric Intake
Guiastrennec, B., Sonne, D. P., Hansen, M., Bagger, J. I., Lund, A., Rehfeld, J., Alskär, O., Karlsson, M., Vilsbøll, T., Knop, F. K., et al. (2016) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12152 · Cited by 22
Influence of gastrointestinal factors on glucose metabolism in patients with cirrhosis
Junker, A. E., Gluud, L. L., Holst, J. J., Knop, F. K., & Vilsbøll, T. (2015) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12981 · Cited by 21
Body Position Modulates Gastric Emptying and Affects the Post-Prandial Rise in Plasma Amino Acid Concentrations Following Protein Ingestion in Humans
Holwerda, A., Lenaerts, K., Bierau, J., & van Loon, L. V. (2016) · Nutrients · doi:10.3390/nu8040221 · Cited by 19
The Gut Microbiome and Abiotic Factors as Potential Determinants of Postprandial Glucose Responses: A Single-Arm Meal Study
Nestel, N., Hvass, J. D., Bahl, M. I., Hansen, L. H., Krych, Ł., Nielsen, D. S., Dragsted, L. O., & Roager, H. M. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2020.594850 · Cited by 21
Delayed gastric emptying and intestinal hormones following pancreatoduodenectomy
Strömmer, L., Räty, S., Hennig, R., Adrian, T. E., Friess, H., Böttiger, Y., Stanaitis, J., NORDBACK, I. H., Sand, J. A., & Arnelo, U. (2005) · Pancreatology · doi:10.1159/000086544 · Cited by 21
Perioperative management of patients on GLP-1 receptor agonists: Risks, recommendations, and future directions—A narrative review
Li, X., Jin, Y., Feng, X.-Y., Wang, R.-C., Chen, J.-P., & Lu, B. (2025) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2025.111871 · Cited by 22
The role of gastric function in control of food intake (and body weight) in relation to obesity, as well as pharmacological and surgical interventions
Camilleri, M. (2023) · Neurogastroenterology & Motility · doi:10.1111/nmo.14660 · Cited by 24
The GLP-1 receptor agonist lixisenatide reduces postprandial glucose in patients with diabetes secondary to total pancreatectomy: a randomised, placebo-controlled, double-blinded crossover trial
Juel, C. T., Lund, A., Andersen, M. M., Hansen, C. P., Storkholm, J. H., Rehfeld, J. F., van Hall, G., Hartmann, B., Albrechtsen, N. J. W., Holst, J. J., et al. (2020) · Diabetologia · doi:10.1007/s00125-020-05158-9 · Cited by 21
Interindividual variability in plasma concentrations after systemic exposure of swine to dietary doxycycline supplied with and without paracetamol: A population pharmacokinetic approach1
del Castillo, J. R. E., Laroute, V., Pommier, P., Zemirline, C., Keïta, A., Concordet, D., & Toutain, P. (2006) · Journal of Animal Science · doi:10.2527/jas.2005-561 · Cited by 20
A Randomized, Placebo-Controlled Crossover Study to Evaluate Postprandial Glucometabolic Effects of Mulberry Leaf Extract, Vitamin D, Chromium, and Fiber in People with Type 2 Diabetes
Mohamed, M., Zagury, R., Bhaskaran, K., Neutel, J., Yusof, B. N. M., Mooney, L., Yeo, L., Kirwan, B., Aprikian, O., von Eynatten, M., et al. (2023) · Diabetes Therapy · doi:10.1007/s13300-023-01379-4 · Cited by 19
Semimechanistic model describing gastric emptying and glucose absorption in healthy subjects and patients with type 2 diabetes
Alskär, O., Bagger, J. I., Røge, R. M., Knop, F. K., Karlsson, M. O., Vilsbøll, T., & Kjellsson, M. C. (2015) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.602 · Cited by 20
Effects of Fat Supplementation on Postprandial GIP, GLP-1, Ghrelin and IGFBP-1 Levels: A Pilot Study on Adolescents with Type 1 Diabetes
Lodefalk, M., Carlsson‐Skwirut, C., Holst, J. J., Åman, J., & Bang, P. (2010) · Hormone Research in Paediatrics · doi:10.1159/000308168 · Cited by 19
Effect of food on gastrointestinal transit of liquids in cynomolgus monkeys
Kondo, H., Watanabe, T., Yokohama, S., & Watanabe, J. (2003) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.349 · Cited by 19
Effects of Oral Mitemcinal (GM-611), Erythromycin, EM-574 and Cisapride on Gastric Emptying in Conscious Rhesus Monkeys
Yogo, K., Onoma, M., Ozaki, K., Koto, M., Itoh, Z., Ōmura, S., & Takanashi, H. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-9951-9 · Cited by 19
Carbohydrate-insulin model: does the conventional view of obesity reverse cause and effect?
Ludwig, D. S. (2023) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2022.0211 · Cited by 22

Validation of the paracetamol absorption test for measuring gastric tube emptying in esophagectomized patients versus gold standard scintigraphy
Djerf, P., Brundin, M., Bajk, M., & Smedh, U. (2015) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2015.1041151 · Cited by 7
Gastric emptying: a comparison of three methods
Glerup, H., Bluhme, H., Villadsen, G. E., Rasmussen, K., Ejskjær, N., & Dahlerup, J. F. (2007) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520701370922 · Cited by 45
Gastric Emptying: Comparison of Scintigraphic, Polyethylene Glycol Dilution, and Paracetamol Tracer Assessment Techniques
Näslund, E. B. (2000) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655200750023930 · Cited by 111
Acetaminophen absorption for gastric emptying revisited
Sanaka, M., & Yamamoto, T. (2026) · Journal of Smooth Muscle Research · doi:10.1540/jsmr.62.55
The validity of a novel paracetamol absorption test for gastric emptying
Medhus, A. W., Lofthus, C. M., Bredesen, J. E., & Husebye, E. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)82644-x · Cited by 2

Authors: Willems, M., Quartero, A. O., & Numans, M. E.
Affiliations: University Medical Center Utrecht (NL)
ORCID: Numans, Mattijs E.
Venue: Digestive Diseases and Sciences
Publisher: Springer Science and Business Media LLC
Published: 2001-10
Volume: 46
Issue: 10
Pages: 2256-2262
ISSN: 0163-2116 (ISSN-L)
1573-2568
DOI: 10.1023/a:1011935603893
OpenAlex: W1510097375
Cited by: 211
References: 41
Citations by year: 2026: 7 · 2025: 10 · 2024: 12 · 2023: 14 · 2022: 12 · 2021: 11 · 2020: 14 · 2019: 8 · 2018: 4 · 2017: 8 · 2016: 9 · 2015: 11 · 2014: 8 · 2013: 16 · 2012: 9
FWCI: 2.83
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Digestive Diseases and Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
Keywords: gastric emptying, scintigraphy, functional dyspepsia, delayed gastric emptying, test validity, test standardization, test length
MeSH terms: Acetaminophen, Dyspepsia, Gastric Emptying, Humans, Intestinal Absorption, Reproducibility of Results, Analgesics, Non-Narcotic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How Useful Is Paracetamol Absorption as a Marker of Gastric Emptying? A Systematic Literature Study

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks