Diabetes mellitus and pancreaticcancer mortality in a prospectivecohort of United States adults
Abstract
Objectives Diabetes mellitus and pancreatic cancer are known to be associated, but it is not known whether diabetes is a true risk factor, preceding development of the cancer, or if it is an early manifestation of the cancer. To address this uncertainty, we examined the association of pancreatic cancer mortality and reported diabetes of at least one year's duration in a large, prospective study of United States adults. The vast majority of diabetes in this cohort is likely to be non-insulin-dependent diabetes.Methods After 12 years of follow-up, 2,953 deaths from pancreatic cancer were observed in a cohort of 1,089,586 men and women who were cancer-free at study entry in 1982. Cox proportional hazards models, adjusted for age, race, smoking, family history of pancreatic cancer, body mass index (wt/ht2), and education, were used to assess associations.Results A history of diabetes was significantly related to pancreatic cancer mortality in both men (rate ratio [RR] = 1.49, 95 percent confidence interval [CI] = 1.25-1.77) and women (RR = 1.51, CI = 1.24-1.85). However, the strength of the association varied over the follow-up period. The death rate from pancreatic cancer was twice as high in diabetics as in non-diabetics during the second and third years of follow-up (adjusted RR = 2.05, CI = 1.56-2.69) but only about 40 percent higher in years nine to 12 (adjusted RR = 1.38, CI = 1.08-1.77).Conclusions The small but persistent increased risk of death from pancreatic cancer, seen even when the diagnosis of diabetes preceded death by many years, supports the hypothesis that diabetes may be a true, albeit modest, risk factor for pancreatic cancer.
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Type 2 diabetes is associated with increased risk of cancers of the colon, pancreas, and possibly other sites.
“Physical activity also helps to prevent type 2 diabetes, which has been associated with increased risk of cancers of the colon, pancreas, and possibly other sites.[115][116][117][118]”
Physical activity helps to prevent type 2 diabetes.
“Physical activity also helps to prevent type 2 diabetes, which has been associated with increased risk of cancers of the colon, pancreas, and possibly other sites.[115][116][117][118]”
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Retracted
- Authors
- Calle, E. E., Murphy, T. K., Rodriguez, C., Thun, M. J., & Heath, C. W.
- Affiliations
- American Cancer Society (US)
- ORCID
- Calle, Eugenia E.
- Venue
- Cancer Causes & Control
- Published
- 1998-08
- Volume
- 9
- Issue
- 4
- Pages
- 403-410
- ISSN
- 0957-5243 (ISSN-L)
- 1573-7225
- OpenAlex
- W2573750488
- Cited by
- 143
- References
- 39
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 5 · 2014: 9 · 2013: 6 · 2012: 3
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Cancer Causes & Control (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Keywords
- diabetes mellitus, pancreatic cancer, pancreatic cancer mortality, type 2 diabetes, cancer risk factors, temporal association, prospective cohort
- MeSH terms
- Adult, Aged, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Pancreatic Neoplasms, Prospective Studies, Risk Factors, United States, Cohort Studies, Comorbidity, Incidence, Survival Rate, Confidence Intervals, Proportional Hazards Models, Age Distribution, Sex Distribution
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