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Cited by 373

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Energetics of Functional Activation in Neural Tissues

Open access
Sokoloff, Louis·1999·Neurochemical Research
DOI 10.1023/a:1022534709672
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Abstract

Glucose utilization (lCMRglc) increases linearly with spike frequency in neuropil but not perikarya of functionally activated neural tissues. Electrical stimulation, increased extracellular [K+] ([K+]0), or opening of Na+ channels with veratridine stimulates 1CMRglc in neural tissues; these increases are blocked by ouabain, an inhibitor of Na+,K+-ATPase. Stimulating Na+,K+-ATPase activity to restore ionic gradients degraded by enhanced spike activity appears to trigger these increases in lCMRglc. Cultured neurons behave similarly. Astrocytic processes that envelop synapses in neuropil probably contribute to the increased lCMRglc. lCMRglc in cultured astroglia is unaffected by elevated [K+]0 but is stimulated by increased intracellular [Na+] ([Na+]i), and this stimulation is blocked by ouabain or tetrodotoxin. L-Glutamate also stimulates lCMRglc in astroglia. This effect is unaffected by inhibitors of NMDA or non-NMDA receptors, blocked by ouabain, and absent in Na+-free medium; it appears to be mediated by increased [Na+]i due to combined uptake of Na+ with glutamate via Na+/glutamate co-transporters.

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Metadata

Authors
Sokoloff, L.
Venue
Neurochemical Research
Publisher
Springer Science and Business Media LLC
Published
1999-02
Volume
24
Issue
2
Pages
321-329
ISSN
  • 0364-3190 (ISSN-L)
  • 1573-6903
DOI
10.1023/a:1022534709672
OpenAlex
W391810772
Cited by
373
References
2
FWCI
3.21
Type
journal article
Language
en
Open access
green

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