Cited by 154Molecular Sensors and Ion DetectionLuminescence and Fluorescent MaterialsAdvanced Fluorescence Microscopy Techniques

Fluorescence Glucose Detection: Advances Toward the Ideal In Vivo Biosensor

Moschou, Elizabeth A., Sharma, Bethel V., Deo, Sapna K., Daunert, Sylvia·2004·Journal of Fluorescence

Abstract

The importance of glucose monitoring for in vivo as well as for ex vivo applications has driven a vast number of scientific groups to pursue the development of an advanced glucose sensor. Such a sensor must be robust, versatile, and capable of the long-term, accurate and reproducible detection of glucose levels in various testing media. Among the different configurations and signal transduction mechanisms used, fluorescence-based glucose sensors constitute a growing class of glucose sensors represented by an increasing number of significant contributions to the field over the last few years. This manuscript reviews the progress in the development of fluorescence based glucose sensors resulting from the advances in the design of new receptor systems for glucose recognition and the utilization of new fluorescence transduction schemes.

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Crossref · 10.1023/b:jofl.0000039341.64999.83

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49 of 49 references verified0 citation errors · 0 not checkable

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  • Photobleaching of fluorophores and tissue scattering are significant drawbacks of optical glucose detection.

    “Photobleaching of the fluorophore and scattering in tissue are significant drawbacks.19,35–36”
  • Optical glucose detection is sensitive and does not damage the host, but skin pigmentation and epidermal thickness can worsen analytical response.

    “While optical detection provides sensitive detection without damaging the host, skin pigmentation and epidermal thickness can negatively impact the analytical response among hosts.35–36”

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Authors
Moschou, E. A., Sharma, B. V., Deo, S. K., & Daunert, S.
Affiliations
University of Kentucky (US)
Corresponding author
Daunert, Sylvia
Venue
Journal of Fluorescence
Published
2004-09
Volume
14
Issue
5
Pages
535-547
ISSN
  • 1053-0509 (ISSN-L)
  • 1573-4994
OpenAlex
W2042531272
Cited by
154
References
49
Citations by year
2026: 2 · 2025: 4 · 2024: 2 · 2022: 3 · 2021: 7 · 2020: 8 · 2019: 6 · 2018: 9 · 2017: 4 · 2016: 8 · 2015: 10 · 2014: 8 · 2013: 8 · 2012: 14
FWCI
3.02
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Fluorescence (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
Keywords
glucose sensor, fluorescent biosensor, in vivo glucose monitoring, glucose recognition, glucose receptor
MeSH terms
Geobacillus stearothermophilus, Boronic Acids, Fluorescent Dyes, Fluorometry, Glucokinase, Glucose, Glucose Oxidase, Humans, Monitoring, Physiologic, Monosaccharide Transport Proteins, Mutation, Protein Conformation, Biosensing Techniques, Molecular Structure, Fluorescence Resonance Energy Transfer, Lectins

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