Fluorescence Glucose Detection: Advances Toward the Ideal In Vivo Biosensor
Abstract
The importance of glucose monitoring for in vivo as well as for ex vivo applications has driven a vast number of scientific groups to pursue the development of an advanced glucose sensor. Such a sensor must be robust, versatile, and capable of the long-term, accurate and reproducible detection of glucose levels in various testing media. Among the different configurations and signal transduction mechanisms used, fluorescence-based glucose sensors constitute a growing class of glucose sensors represented by an increasing number of significant contributions to the field over the last few years. This manuscript reviews the progress in the development of fluorescence based glucose sensors resulting from the advances in the design of new receptor systems for glucose recognition and the utilization of new fluorescence transduction schemes.
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Photobleaching of fluorophores and tissue scattering are significant drawbacks of optical glucose detection.
“Photobleaching of the fluorophore and scattering in tissue are significant drawbacks.19,35–36”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [35]
Optical glucose detection is sensitive and does not damage the host, but skin pigmentation and epidermal thickness can worsen analytical response.
“While optical detection provides sensitive detection without damaging the host, skin pigmentation and epidermal thickness can negatively impact the analytical response among hosts.35–36”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [35]
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- Authors
- Moschou, E. A., Sharma, B. V., Deo, S. K., & Daunert, S.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Daunert, Sylvia
- Venue
- Journal of Fluorescence
- Published
- 2004-09
- Volume
- 14
- Issue
- 5
- Pages
- 535-547
- ISSN
- 1053-0509 (ISSN-L)
- 1573-4994
- OpenAlex
- W2042531272
- Cited by
- 154
- References
- 49
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2022: 3 · 2021: 7 · 2020: 8 · 2019: 6 · 2018: 9 · 2017: 4 · 2016: 8 · 2015: 10 · 2014: 8 · 2013: 8 · 2012: 14
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Fluorescence (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
- Keywords
- glucose sensor, fluorescent biosensor, in vivo glucose monitoring, glucose recognition, glucose receptor
- MeSH terms
- Geobacillus stearothermophilus, Boronic Acids, Fluorescent Dyes, Fluorometry, Glucokinase, Glucose, Glucose Oxidase, Humans, Monitoring, Physiologic, Monosaccharide Transport Proteins, Mutation, Protein Conformation, Biosensing Techniques, Molecular Structure, Fluorescence Resonance Energy Transfer, Lectins
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