Single-Cell Gene Expression Analysis: Implications for Neurodegenerative and Neuropsychiatric Disorders
Abstract
Technical and experimental advances in microaspiration techniques, RNA amplification, quantitative real-time polymerase chain reaction (qPCR), and cDNA microarray analysis have led to an increase in the number of studies of single-cell gene expression. In particular, the central nervous system (CNS) is an ideal structure to apply single-cell gene expression paradigms. Unlike an organ that is composed of one principal cell type, the brain contains a constellation of neuronal and noneuronal populations of cells. A goal is to sample gene expression from similar cell types within a defined region without potential contamination by expression profiles of adjacent neuronal subpopulations and noneuronal cells. The unprecedented resolution afforded by single-cell RNA analysis in combination with cDNA microarrays and qPCR-based analyses allows for relative gene expression level comparisons across cell types under different experimental conditions and disease states. The ability to analyze single cells is an important distinction from global and regional assessments of mRNA expression and can be applied to optimally prepared tissues from animal models as well as postmortem human brain tissues. This focused review illustrates the potential power of single-cell gene expression studies within the CNS in relation to neurodegenerative and neuropsychiatric disorders such as Alzheimer's disease (AD) and schizophrenia, respectively.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Purifying cell populations or performing single-cell transcriptional analyses can identify important changes not apparent in whole-tissue transcriptomes.
“Purifying cell populations or carrying out transcriptional analyses on single cells158–163 can identify important changes that are not apparent in whole-tissue transcriptomes141,142.”
From Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015) · cites this paper as [158]
Cites
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589 · see citing works
The cholinergic hypothesis of geriatric memory dysfunction
Bartus, R. T., Dean, R. L., Beer, B., & Lippa, A. S. (1982) · Science · doi:10.1126/science.7046051 · Cited by 5,545 · see citing works
Correlation between Protein and mRNA Abundance in Yeast
Gygi, S. P., Rochon, Y., Franza, B. R., & Aebersold, R. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.1720 · Cited by 3,819 · see citing works
Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain
Whitehouse, P., Price, D., Struble, R., Clark, A., Coyle, J., & DeLong, M. R. (1982) · Science · doi:10.1126/science.7058341 · Cited by 3,627 · see citing works
SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE
DAVIES, P. (1976) · The Lancet · doi:10.1016/s0140-6736(76)91936-x · Cited by 3,565 · see citing works
Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging
Mori, S., Crain, B. J., Chacko, V. P., & van Zijl, P. C. M. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199902)45:2 · Cited by 3,479 · see citing works
Self-citationExpression monitoring by hybridization to high-density oligonucleotide arrays
Lockhart, D. J., Dong, H., Byrne, M. C., Follettie, M. T., Gallo, M. V., Chee, M. S., Mittmann, M., Wang, C., Kobayashi, M., Norton, H., et al. (1996) · Nature Biotechnology · doi:10.1038/nbt1296-1675 · Cited by 2,841 · see citing works
Holland, P. M., Abramson, R. D., Watson, R., & Gelfand, D. H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.7276 · Cited by 2,694 · see citing works
Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems
Bustin, S. A. (2002) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0290023 · Cited by 2,553 · see citing works
Emmert‐Buck, M. R., Bonner, R. F., Smith, P. D., Chuaqui, R. F., Zhuang, Z., Goldstein, S. R., Weiss, R. A., & Liotta, L. A. (1996) · Science · doi:10.1126/science.274.5289.998 · Cited by 2,540 · see citing works
Exploring the new world of the genome with DNA microarrays
Brown, P. O., & Botstein, D. (1999) · Nature Genetics · doi:10.1038/4462 · Cited by 2,430 · see citing works
Mesulam, M. ‐., Mufson, E. J., Levey, A. I., & Wainer, B. H. (1983) · Journal of Comparative Neurology · doi:10.1002/cne.902140206 · Cited by 1,962 · see citing works
Self-citationLock, C., Hermans, G., Pedotti, R., Brendolan, A., Schadt, E. E., Garren, H., Langer-Gould, A. M., Strober, S., Cannella, B., Allard, J. D., et al. (2002) · Nature Medicine · doi:10.1038/nm0502-500 · Cited by 1,659 · see citing works
Hakak, Y., Walker, J. R., Li, C., Wong, W. H., Davis, K. L., Buxbaum, J. D., Haroutunian, V., & Fienberg, A. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081071198 · Cited by 1,192 · see citing works
[12] DNA arrays for analysis of gene expression
Eisen, M. B., & Brown, P. O. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)03014-1 · Cited by 1,043 · see citing works
THE CONTINUITY OF PSYCHOTIC EXPERIENCES IN THE GENERAL POPULATION
Johns, L. C., & van Os, J. (2001) · Clinical Psychology Review · doi:10.1016/s0272-7358(01)00103-9 · Cited by 960 · see citing works
Analysis of gene expression in single live neurons.
Eberwine, J. H., Yeh, H., Miyashiro, K., Cao, Y., Nair, S., Finnell, R. H., Zettel, M. F., & Coleman, P. D. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.7.3010 · Cited by 953 · see citing works
Self-citationRelationship of microglia and astrocytes to amyloid deposits of Alzheimer disease
Itagaki, S., McGeer, P. L., Akiyama, H., Zhu, S., & Selkoe, D. (1989) · Journal of Neuroimmunology · doi:10.1016/0165-5728(89)90115-x · Cited by 940 · see citing works
Hashimoto, T., Volk, D. W., Eggan, S. M., Mirnics, K., Pierri, J. N., Sun, Z., Sampson, A. R., & Lewis, D. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06315.2003 · Cited by 938 · see citing works
Mirnics, K., Middleton, F. A., Marquez, A., Lewis, D. A., & Levitt, P. (2000) · Neuron · doi:10.1016/s0896-6273(00)00085-4 · Cited by 882 · see citing works
Laser Capture Microdissection: Molecular Analysis of Tissue
Bonner, R. F., Emmert‐Buck, M. R., Cole, K. A., Pohida, T. J., Chuaqui, R. F., Goldstein, S. R., & Liotta, L. A. (1997) · Science · doi:10.1126/science.278.5342.1481 · Cited by 877 · see citing works
Alzheimer's Disease--Genotypes, Phenotype, and Treatments
Selkoe, D. J. (1997) · Science · doi:10.1126/science.275.5300.630 · Cited by 871 · see citing works
Espina, V. A., Wulfkuhle, J. D., Calvert, V. S., VanMeter, A., Zhou, W., Coukos, G., Geho, D. H., Petricoin, E. F., & Liotta, L. A. (2006) · Nature Protocols · doi:10.1038/nprot.2006.85 · Cited by 847 · see citing works
Zola-Morgan, S. M., & Squire, L. R. (1993) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.16.030193.002555 · Cited by 740 · see citing works
Bierer, L. M., Haroutunian, V. H., Gabriel, S., Knott, P. J., Carlin, L. S., Purohit, D. P., Perl, D. P., Schmeidler, J., Kanof, P. D., & Davis, K. L. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64020749.x · Cited by 580 · see citing works
Blalock, E. M., Chen, K.-C., Sharrow, K., Herman, J. P., Porter, N. M., Foster, T. C., & Landfield, P. W. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-09-03807.2003 · Cited by 570 · see citing works
Colangelo, V., Schurr, J., Ball, M. J., Pelaez, R. P., Bazan, N. G., & Lukiw, W. J. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10351 · Cited by 517 · see citing works
Detection of nucleic acid hybridization by nonradiative fluorescence resonance energy transfer.
Cardullo, R. A., Agrawal, S., Flores, C., Zamecnik, P. C., & Wolf, D. E. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.23.8790 · Cited by 491 · see citing works
Gene Expression Profiling Reveals Alterations of Specific Metabolic Pathways in Schizophrenia
Middleton, F. A., Mirnics, K., Pierri, J. N., Lewis, D. A., & Levitt, P. R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02718.2002 · Cited by 428 · see citing works
Cataldo, A. M., Barnett, J. L., Berman, S. A., Li, J., Quarless, S., Bursztajn, S., Lippa, C., & Nixon, R. A. (1995) · Neuron · doi:10.1016/0896-6273(95)90324-0 · Cited by 379 · see citing works
Immuno-LCM: Laser Capture Microdissection of Immunostained Frozen Sections for mRNA Analysis
Fend, F., Emmert‐Buck, M. R., Chuaqui, R. F., Cole, K. A., Lee, J., Liotta, L. A., & Raffeld, M. A. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65251-0 · Cited by 378 · see citing works
Zola‐Morgan, S., Squire, L. R., & Ramus, S. J. (1994) · Hippocampus · doi:10.1002/hipo.450040410 · Cited by 362 · see citing works
Cognitive functions of the basal forebrain
Baxter, M. G., & Chiba, A. A. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80024-5 · Cited by 351 · see citing works
Cataldo, A., Hamilton, D. J., Barnett, J. L., Paskevich, P. A., & Nixon, R. A. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-01-00186.1996 · Cited by 350 · see citing works
The Endosomal-Lysosomal System of Neurons in Alzheimer's Disease Pathogenesis: A Review
Nixon, R., Cataldo, A., & Mathews, P. (2000) · Neurochemical Research · doi:10.1023/a:1007675508413 · Cited by 332 · see citing works
Lazarov, O., Lee, M., Peterson, D. A., & Sisodia, S. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-22-09785.2002 · Cited by 302 · see citing works
A Gene Expression Profile of Alzheimer's Disease
Loring, J. F., Wen, X., Lee, J. M., Seilhamer, J. J., & Somogyi, R. (2001) · DNA and Cell Biology · doi:10.1089/10445490152717541 · Cited by 300 · see citing works
Age-related declines in nigral neuronal function correlate with motor impairments in rhesus monkeys
Emborg, M. E., Ma, S. Y., Mufson, E. J., Levey, A. I., Taylor, M. D., Brown, W. D., Holden, J. E., & Kordower, J. H. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19981116)401:2 · Cited by 298 · see citing works
Self-citationMufson, E. J., Bothwell, M. A., & Kordower, J. H. (1989) · Experimental Neurology · doi:10.1016/0014-4886(89)90124-6 · Cited by 279 · see citing works
Self-citationYoshihara, T., Ishigaki, S., Yamamoto, M., Liang, Y., Jun, Niwa, I., Takeuchi, H., Doyu, M., & Sobue, G. (2001) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00683.x · Cited by 275 · see citing works
Buxbaum, J. D., Thinakaran, G., Koliatsos, V. E., O’Callahan, J., Slunt, H. H., Price, D. L., & Sisodia, S. S. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09629.1998 · Cited by 266 · see citing works
Dopamine transporters decrease with age.
Volkow, N. D., Ding, Y., Fowler, J. S., Wang, G., Logan, J., Gatley, S. J., Hitzemann, R., Smith, G., Fields, S. D., & Gur, R. C. (1996) · PubMed · Cited by 262 · see citing works
Cholinergic Innervation in Neuritic Plaques
Struble, R. G., Cork, L. C., Whitehouse, P. J., & Price, D. L. (1982) · Science · doi:10.1126/science.6803359 · Cited by 249 · see citing works
Grünblatt, E., Mandel, S. A., Maor, G., & Youdim, M. B. H. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00397.x · Cited by 246 · see citing works
Dickey, C. A., Loring, J. F., Montgomery, J., Gordon, M. N., Eastman, P. S., & Morgan, D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05219.2003 · Cited by 242 · see citing works
Gene Expression Profile for Schizophrenia
Hemby, S. E., Ginsberg, S. D., Brunk, B. P., Arnold, S. E., Trojanowski, J. Q., & Eberwine, J. H. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.7.631 · Cited by 234 · see citing works
Self-citationFunctional imaging studies of dopamine system and cognition in normal aging and Parkinson's disease
Kaasinen, V., & Rinne, J. O. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00065-9 · Cited by 225 · see citing works
Kurtz, M. M., Moberg, P. J., Gur, R. C., & Gur, R. E. (2001) · Neuropsychology Review · doi:10.1023/a:1012953108158 · Cited by 221 · see citing works
Malaspina, A., Kaushik, N. K., & de Belleroche, J. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.t01-1-00231.x · Cited by 212 · see citing works
The role of complement and activated microglia in the pathogenesis of Alzheimer's disease
Eikelenboom, P., & Veerhuis, R. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00108-x · Cited by 206 · see citing works
Arnold, S. E., Trojanowski, J. Q., Gur, R. E., Blackwell, P., Han, L., & Choi, C. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.3.225 · Cited by 199 · see citing works
Self-citationTranscriptional profiling reveals strict boundaries between hippocampal subregions
Zhao, X., Lein, E. S., He, A., Smith, S. C., Aston, C., & Gage, F. H. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1406 · Cited by 196 · see citing works
Evolution of Alzheimer's disease-related cytoskeletal changes in the basal nucleus of Meynert
Sassin, I., Schultz, C., Thal, D. R., Rüb, U., Arai, K., Braak, E., & Braak, H. (2000) · Acta Neuropathologica · doi:10.1007/s004019900178 · Cited by 193 · see citing works
Age-dependent decline in human brain dopamine D1 and D2 receptors
Rinne, J. O., Lönnberg, P., & Marjamäki, P. (1990) · Brain Research · doi:10.1016/0006-8993(90)90423-9 · Cited by 192 · see citing works
IDENTIFICATION OF CYTOPLASMIC BASOPHILIA (RIBONUCLEIC ACID) BY FLUORESCENCE MICROSCOPY
von Bertalanffy, L., & Bickis, I. J. (1956) · Journal of Histochemistry & Cytochemistry · doi:10.1177/4.5.481 · Cited by 188 · see citing works
Sequestration of RNA in Alzheimer's disease neurofibrillary tangles and senile plaques
Ginsberg, S. D., Crino, P. B., Lee, V. M. ‐., Eberwine, J. H., & Trojanowski, J. Q. (1997) · Annals of Neurology · doi:10.1002/ana.410410211 · Cited by 188 · see citing works
Self-citationDopamine transporter mRNA content in human substantia nigra decreases precipitously with age.
Bannon, M. J., Poosch, M. S., Xia, Y., Goebel, D. J., Cassin, B., & Kapatos, G. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.15.7095 · Cited by 181 · see citing works
Mimmack, M. L., Ryan, M., Baba, H., Navarro-Ruiz, J., Iritani, S., Faull, R. L. M., McKenna, P. J., Jones, P. B., Arai, H., Starkey, M. P., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032069099 · Cited by 180 · see citing works
Parallel loss of presynaptic and postsynaptic dopamine markers in normal aging
Volkow, N. D., Wang, G., Fowler, J. S., Ding, Y., Gur, R. C., Gatley, J. S., Logan, J., Moberg, P. J., Hitzemann, R., Smith, G., et al. (1998) · Annals of Neurology · doi:10.1002/ana.410440125 · Cited by 172 · see citing works
[1] Preparation of cDNA from single cells and subcellular regions
Kacharmina, J. E., Crino, P. B., & Eberwine, J. H. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)03003-7 · Cited by 166 · see citing works
Self-citationHippocampal dopamine D2 receptors correlate with memory functions in Alzheimer's disease
Kemppainen, N. M., Laine, M., Laakso, M. P., Kaasinen, V., Någren, K., Vahlberg, T. J., Kurki, T. J. I., & Rinne, J. O. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02716.x · Cited by 164 · see citing works
Mycko, M., Papoian, R., Boschert, U., Raine, C., & Selmaj, K. (2003) · Brain : a journal of neurology · doi:10.1093/brain/awg107 · Cited by 152 · see citing works
Reyes, T. M., Walker, J. R., DeCino, C., Hogenesch, J. B., & Sawchenko, P. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05607.2003 · Cited by 149 · see citing works
Presence and phosphorylation of transcription factors in developing dendrites
Crino, P. B., Khodakhah, K., Becker, K. G., Ginsberg, S. D., Hemby, S. E., & Eberwine, J. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2313 · Cited by 149 · see citing works
Self-citationCarmel, J. B., Galante, A., Soteropoulos, P., Tolias, P. P., Recce, M. L., Young, W., & Hart, R. P. (2001) · Physiological Genomics · doi:10.1152/physiolgenomics.00074.2001 · Cited by 148 · see citing works
Gene expression profiling in the post-mortem human brain — no cause for dismay
Bahn, S., Augood, S. J., Ryan, M., Standaert, D. G., Starkey, M., & Emson, P. C. (2001) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(01)00099-0 · Cited by 146 · see citing works
RNA sequestration to pathological lesions of neurodegenerative diseases
Ginsberg, S. D., Galvin, J. E., Chiu, T.-L. S., Lee, V. M. ‐., Masliah, E., & Trojanowski, J. Q. (1998) · Acta Neuropathologica · doi:10.1007/s004010050923 · Cited by 142 · see citing works
Self-citationVolkow, N. D., Wang, G., Fowler, J. S., Logan, J., Gatley, S. J., MacGregor, R. R., Schlyer, D. J., HITZEMANN, R. J., & Wolf, A. P. (1996) · Psychiatry Research Neuroimaging · doi:10.1016/0925-4927(96)02809-0 · Cited by 140 · see citing works
Gene Expression Profiles of Cholinergic Nucleus Basalis Neurons in Alzheimer's Disease
Mufson, E. J., Counts, S., & Ginsberg, S. D. (2002) · Neurochemical Research · doi:10.1023/a:1020952704398 · Cited by 138 · see citing works
Self-citationSensitive Immunoassay of Tissue Cell Proteins Procured by Laser Capture Microdissection
Simone, N. L., Remaley, A. T., Charboneau, L., Petricoin, E. F., III, Glickman, J., Emmert‐Buck, M. R., Fleisher, T. A., & Liotta, L. A. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64749-9 · Cited by 136 · see citing works
Unbiased morphometrical measurements show loss of pigmented nigral neurones with ageing
Ma, Röytt, Collan, & Rinne (1999) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.1999.00202.x · Cited by 133 · see citing works
Age‐related and regional differences in dopamine transporter mRNA expression in human midbrain
Bannon, M. J., & Whitty, C. W. M. (1997) · Neurology · doi:10.1212/wnl.48.4.969 · Cited by 130 · see citing works
Laser Capture Microdissection of Single Cells from Complex Tissues
Suarez‐Quian, C. A., Goldstein, S. R., Pohida, T. J., Smith, P. D., Peterson, J. I., Wellner, E., Ghany, M. G., & Bonner, R. F. (1999) · BioTechniques · doi:10.2144/99262rr03 · Cited by 129 · see citing works
Sheng, J. G., Price, D. L., & Koliatsos, V. E. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-22-09794.2002 · Cited by 124 · see citing works
Biological stability of mRNA isolated from human postmortem brain collections
Leonard, S. S., Logel, J., Luthman, D., Casanova, M. F., Kirch, D. G., & Freedman, R. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90174-c · Cited by 112 · see citing works
DNA microarray analysis of the aging brain
Prolla, T. A. (2002) · Chemical Senses · doi:10.1093/chemse/27.3.299 · Cited by 110 · see citing works
Cholinergic neuropathology in a mouse model of Alzheimer's disease
German, D. C., Yazdani, U., Speciale, S. G., Pasbakhsh, P., Games, D., & Liang, C. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10737 · Cited by 99 · see citing works
Neuron‐specific age‐related decreases in dopamine receptor subtype mRNAs
Hemby, S. E., Trojanowski, J. Q., & Ginsberg, S. D. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10525 · Cited by 95 · see citing works
Self-citationAkil, M., Edgar, C. L., Pierri, J. N., Casali, S., & Lewis, D. A. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00282-6 · Cited by 92 · see citing works
Antoine, J.-C. G., Cinotti, L., Tilikete, C., Bouhour, F., Camdessanch�, J. P., Confavreux, C., Vighetto, A., Renault‐Mannel, V., Michel, D., & Honnorat, J. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200007)48:1 · Cited by 86 · see citing works
Self-citationAmplification of RNA transcripts using terminal continuation
Che, S., & Ginsberg, S. D. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700005 · Cited by 83 · see citing works
Self-citationmRNA Expression Analysis of Tissue Sections and Single Cells
Eberwine, J. H., Kacharmina, J. E., Andrews, C., Miyashiro, K., McIntosh, T. K., Becker, K. G., Barrett, T., Hinkle, D., Dent, G. W., & Marciano, P. G. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08310.2001 · Cited by 80 · see citing works
Self-citationThe Neurofibrillary Pathology of Alzheimer's Disease
Goedert, M. (1997) · The Neuroscientist · doi:10.1177/107385849700300212 · Cited by 77 · see citing works
Using cDNA microarray to assess Parkinson's disease models and the effects of neuroprotective drugs
Mandel, S. A., Weinreb, O., & Youdim, M. B. H. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(03)00067-1 · Cited by 69 · see citing works
RNA Amplification in Brain Tissues
Ginsberg, S. D., & Che, S. (2002) · Neurochemical Research · doi:10.1023/a:1020944502581 · Cited by 66 · see citing works
Self-citationCounts, S. (2003) · Molecular Interventions · doi:10.1124/mi.3.3.137 · Cited by 64 · see citing works
Self-citationCullen, K. M., & Halliday, G. M. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00066-9 · Cited by 59 · see citing works
Dopamine D2 receptors in the hippocampus and amygdala in Alzheimer's disease
Joyce, J. N., Kaeger, C., Ryoo, H., & Goldsmith, S. K. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90199-u · Cited by 53 · see citing works
GAL4/UAS-WGA system as a powerful tool for tracingDrosophila transsynaptic neural pathways
Tabuchi, K., Sawamoto, K., Suzuki, E., Ozaki, K., Sone, M., Hama, C., Morimoto-Tanifuji, T., Yuasa, Y., Yoshihara, Y., Nose, A., et al. (2000) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(20000101)59:1 · Cited by 51 · see citing works
Brail, L. H., Jang, A., Billia, F., Iscove, N. N., Klamut, H. J., & Hill, R. P. (1999) · Mutation Research/Mutation Research Genomics · doi:10.1016/s1383-5726(98)00009-0 · Cited by 47 · see citing works
Regional and neuronal reductions of polyadenylated messenger RNA in Alzheimer's disease
Harrison, P. J., BARTON, A. J. L., Najlerahim, A., McDonald, B., & Pearson, R. C. A. (1991) · Psychological Medicine · doi:10.1017/s0033291700029858 · Cited by 40 · see citing works
Ryoo, H., & Joyce, J. N. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903480105 · Cited by 40 · see citing works
Molecular Pathology of Alzheimer’s Disease and Related Disorders
Ginsberg, S. D., Schmidt, M. L., Crino, P. B., Eberwine, J. H., Lee, V. M. ‐., & Trojanowski, J. Q. (1999) · Cerebral cortex · doi:10.1007/978-1-4615-4885-0_17 · Cited by 38 · see citing works
Self-citationAmenta, F., Mignini, F., Rícci, A., Sabbatini, M., Tomassoni, D., & Tayebati, S. K. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00317-7 · Cited by 38 · see citing works
In situ hybridization-theory and practice.
Kadkol, S. S., Gage, W. R., & Pasternack, G. R. (1999) · PubMed · Cited by 38 · see citing works
In situ hybridization—Theory and practice
Kadkol, S. S., GAGE, W., & Pasternack, G. R. (1999) · Molecular Diagnosis · doi:10.1016/s1084-8592(99)80021-6 · Cited by 33 · see citing works
Lencz, T., PhD, Cornblatt, B., PhD, Bilder, A. R. M., & PhD (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4274 · Cited by 28 · see citing works
A comparative study of quantitative stains for DNA in image cytometry.
Mikel, U. V., & Becker, R. L. (1991) · PubMed · Cited by 26 · see citing works
Herzog, C. R., Noh, S. J., Lantry, L. E., Guan, K.-L., & You, M. (1999) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199906)25:2 · Cited by 26 · see citing works
Serafini, T. A. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00022-7 · Cited by 25 · see citing works
Polyadenylated Messenger RNA in Paired Helical Filament-Immunoreactive Neurons in Alzheimer Disease
Griffin, W. S. T., Ling, C., White, C. L., & Morrison‐Bogorad, M. (1990) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199004020-00001 · Cited by 22 · see citing works
Polyadenylated Messenger RNA in Paired Helical Filament-Immunoreactive Neurons in Alzheimer Disease
Griffin, W. S. T., Chen, L., White, C. L., et al. (1990) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199040200-00001 · Cited by 18 · see citing works
Gliosis and Glioma Distinguished by Acridine Orange
Sarnat, H. B., Curry, B., Rewcastle, N. B., & Trevenen, C. (1987) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100026135 · Cited by 16 · see citing works
Use of acridine orange for histologic analysis of the central nervous system.
Mai, J. K., Schmidt‐Kastner, R., & Tefett, H. B. (1984) · Journal of Histochemistry & Cytochemistry · doi:10.1177/32.1.6197440 · Cited by 15 · see citing works
In Pursuit of the Pathogenesis and Pathophysiology of Schizophrenia: Where Do We Stand?
Lewis, D. A. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.9.1467 · Cited by 14 · see citing works
In Pursuit of the Molecular Neuropathology of Schizophrenia
Trojanowski, J. Q. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950160024005 · Cited by 10 · see citing works
Self-citationSarnat, H. B., Curry, B., Rewcastle, N. B., & Trevenen, C. (1986) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100035769 · Cited by 9 · see citing works
Neuroimaging Applications in Elderly Patients
Gur, R. C., & Gur, R. E. (2002) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200201000-00002 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The interaction of cells and bacteria with surfaces structured at the nanometre scale
Anselme, K., Davidson, P. M., Popa, A., Giazzon, M., Liley, M., & Ploux, L. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.04.001 · Cited by 828 · see citing works
Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders
Parikshak, N. N., Gandal, M. J., & Geschwind, D. H. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3934 · Cited by 430 · see citing works
Genes and pathways underlying regional and cell type changes in Alzheimer’s disease
Miller, J. A., Woltjer, R. L., Goodenbour, J. M., Horvath, S., & Geschwind, D. H. (2013) · Genome Medicine · doi:10.1186/gm452 · Cited by 275 · see citing works
Surget, A., Wang, Y., Leman, S., Ibargüen-Vargas, Y., Edgar, N. M., Griebel, G., Belzung, C., & Sibille, E. L. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.76 · Cited by 195 · see citing works
Hippocampal plasticity during the progression of Alzheimer’s disease
Mufson, E. J., Mahady, L. J., Waters, D., Counts, S., Perez, S. E., DeKosky, S. T., Ginsberg, S. D., Ikonomović, M. D., Scheff, S. W., & Binder, L. I. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.006 · Cited by 172 · see citing works
Self-citationComprehensive qPCR profiling of gene expression in single neuronal cells
Citri, A., Pang, Z. P., Südhof, T. C., Wernig, M., & Malenka, R. C. (2011) · Nature Protocols · doi:10.1038/nprot.2011.430 · Cited by 169 · see citing works
Trimarchi, J. M., Stadler, M. B., Roska, B., Billings, N., Sun, B. B., Bartch, B., & Cepko, C. L. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21368 · Cited by 157 · see citing works
Target Identification for CNS Diseases by Transcriptional Profiling
Altar, C. A., Vawter, M. P., & Ginsberg, S. D. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.172 · Cited by 139 · see citing works
Self-citationMcCurdy, R. D., Feron, F. P., Perry, C., Chant, D. C., McLean, D. E., Matigian, N., Hayward, N. K., McGrath, J. J., & Mackay‐Sim, A. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2005.10.012 · Cited by 138 · see citing works
Transcriptional vulnerability of brain regions in Alzheimer's disease and dementia
Haroutunian, V. H., Katsel, P., & Schmeidler, J. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.07.021 · Cited by 113 · see citing works
Ginsberg, S. D., Che, S., Counts, S. E., & Mufson, E. J. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03641.x · Cited by 111 · see citing works
Self-citationCholinotrophic Molecular Substrates of Mild Cognitive Impairment in the Elderly
Mufson, E. J., Counts, S., Fahnestock, M. L., & Ginsberg, S. D. (2007) · Current Alzheimer Research · doi:10.2174/156720507781788855 · Cited by 100 · see citing works
Self-citationStåhlberg, A., Andersson, D., Aurelius, J., Faiz, M., Pekna, M., Kubista, M., & Pekny, M. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq1182 · Cited by 101 · see citing works
Zucker, B., Luthi‐Carter, R., Kama, J. A., Dunah, A. W., Stern, E. A., Fox, J. H., Standaert, D. G., Young, A. B., & Augood, S. J. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddi014 · Cited by 99 · see citing works
Reduction of β-amyloid and γ-secretase by calorie restriction in female Tg2576 mice
Schafer, M. J., Alldred, M. J., Lee, S. H., Calhoun, M. E., Petkova, E., Mathews, P. M., & Ginsberg, S. D. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.10.043 · Cited by 97 · see citing works
Self-citationGene Expression Profiling in Schizophrenia and Related Mental Disorders
Iwamoto, K., & Kato, T. (2006) · The Neuroscientist · doi:10.1177/1073858406287536 · Cited by 86 · see citing works
Ginsberg, S. D., Alldred, M. J., & Che, S. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.07.013 · Cited by 83 · see citing works
Self-citationDong, X., Zhang, W., Wang, H.-X., Stradtman, G. G., & Gao, W. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114570900042x · Cited by 82 · see citing works
Ploski, J. E., Newton, S. S., & Duman, R. S. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04156.x · Cited by 79 · see citing works
Single cell gene expression profiling in Alzheimer’s disease
Ginsberg, S. D., Che, S., Counts, S., & Mufson, E. J. (2006) · NeuroRx · doi:10.1016/j.nurx.2006.05.007 · Cited by 76 · see citing works
Self-citationDiscovery and development of biomarkers of neurological disease
Dunckley, T. L., Coon, K. D., & Stephan, D. A. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(04)03353-7 · Cited by 76 · see citing works
Transcriptome Analysis of Single Cells
Morris, J. F., Singh, J. M., & Eberwine, J. H. (2011) · Journal of Visualized Experiments · doi:10.3791/2634 · Cited by 68 · see citing works
Self-citationXi, D., Keeler, B. E., Zhang, W., Houlé, J. D., & Gao, W. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2008.09.013 · Cited by 66 · see citing works
Iourov, I. Y., Vorsanova, S. G., & Yurov, Y. B. (2013) · Cytogenetic and Genome Research · doi:10.1159/000347053 · Cited by 65 · see citing works
Analyzing Schizophrenia by DNA Microarrays
Horváth, S., Janka, Z., & Mirnics, K. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.017 · Cited by 64 · see citing works
Ginsberg, S. D., & Che, S. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700110 · Cited by 62 · see citing works
Self-citationTranscriptome profiling in neurodegenerative disease
Courtney, E., Kornfeld, S., Janitz, K., & Janitz, M. (2010) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2010.08.018 · Cited by 61 · see citing works
Ginsberg, S. D., & Che, S. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20535 · Cited by 59 · see citing works
Self-citationAlldred, M. J., Duff, K., & Ginsberg, S. D. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.10.022 · Cited by 58 · see citing works
Self-citationKatsel, P., Davis, K. L., & Haroutunian, V. H. (2005) · International review of neurobiology · doi:10.1016/s0074-7742(05)63003-6 · Cited by 56 · see citing works
Dissecting the Relationship Between Neuropsychiatric and Neurodegenerative Disorders
Gupta, R. V., Advani, D., Yadav, D., Ambasta, R. K., & Kumar, P. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03502-9 · Cited by 58 · see citing works
Counts, S., He, B., Che, S., Ginsberg, S. D., & Mufson, E. J. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1196 · Cited by 53 · see citing works
Self-citationSingle-cell gene-expression profiling and its potential diagnostic applications
Ståhlberg, A., Kubista, M., & Åman, P. (2011) · Expert Review of Molecular Diagnostics · doi:10.1586/erm.11.60 · Cited by 51 · see citing works
Platform influence on DNA microarray data in postmortem brain research
Hollingshead, D. J., Lewis, D. A., & Mirnics, K. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.10.020 · Cited by 51 · see citing works
Perez, S. E., Miguel, J. C., He, B., Malek‐Ahmadi, M. H., Abrahamson, E. E., Ikonomović, M. D., Lott, I. T., Doran, E. W., Alldred, M. J., Ginsberg, S. D., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-01965-6 · Cited by 47 · see citing works
Self-citationCounts, S., Chen, E., Che, S., Ikonomović, M. D., Wuu, J., Ginsberg, S. D., DeKosky, S. T., & Mufson, E. J. (2006) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000090906 · Cited by 48 · see citing works
Self-citationFunctional Genomics meets neurodegenerative disorders
Hoerndli, F. J., David, D. C., & Götz, J. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.07.002 · Cited by 44 · see citing works
Perez, S. E., Getova, D. P., He, B., Counts, S., Geula, C., Désiré, L., Coutadeur, S., Peillon, H., Ginsberg, S. D., & Mufson, E. J. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.10.027 · Cited by 43 · see citing works
Self-citationNeuronal gene expression profiling: uncovering the molecular biology of neurodegenerative disease.
Mufson, E., Counts, S., Che, S.-L., & Ginsberg, S. D. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)58010-0 · Cited by 42 · see citing works
Self-citationFunctional Genomics meets neurodegenerative disorders
David, D. C., Hoerndli, F. J., & Götz, J. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.07.001 · Cited by 39 · see citing works
Alldred, M. J., Penikalapati, S. C., Lee, S. H., Heguy, A., Roussos, P., & Ginsberg, S. D. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02453-3 · Cited by 36 · see citing works
Self-citationMufson, E. J., He, B., Ginsberg, S. D., Carper, B. A., Bieler, G. S., Crawford, F., Alvarez, V. E., Huber, B. R., Stein, T. D., McKee, A. C., et al. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2017.5368 · Cited by 35 · see citing works
Self-citationFunctional genomic methodologies
Ginsberg, S. D., & Mirnics, K. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)58002-1 · Cited by 34 · see citing works
Self-citationExpression profiling in the aging brain: A perspective
Galvin, J. E., & Ginsberg, S. D. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.06.009 · Cited by 32 · see citing works
Self-citationPanelli, S., Damiani, G., Espen, L., Micheli, G., & Sgaramella, V. (2006) · Gene · doi:10.1016/j.gene.2006.01.032 · Cited by 32 · see citing works
Assessment of genome and proteome profiles in cocaine abuse
Hemby, S. E. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)58009-4 · Cited by 31 · see citing works
Self-citationDuftner, N., Larkins‐Ford, J., Legendre, M., & Hofmann, H. A. (2007) · Genomics · doi:10.1016/j.ygeno.2007.09.004 · Cited by 29 · see citing works
Marsh, A. G., & Fielman, K. T. (2005) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.21037 · Cited by 28 · see citing works
Drug targets: single-cell transcriptomics hastens unbiased discovery
Bartfai, T., Buckley, P. T., & Eberwine, J. H. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.09.006 · Cited by 27 · see citing works
Self-citationSingh, S. M., Treadwell, J. A., Kleiber, M. L., Harrison, M., & Uddin, R. K. (2007) · Genome · doi:10.1139/g06-118 · Cited by 26 · see citing works
Cell and Tissue Microdissection in Combination with Genomic and Proteomic Applications
Ginsberg, S. D., Hemby, S. E., Mufson, E. J., & Martin, L. J. (2006) · Springer eBooks · doi:10.1007/0-387-28942-9_4 · Cited by 26 · see citing works
Self-citationMcKeever, P. M., Kim, T. P., Hesketh, A. R., MacNair, L., Miletic, D., Favrin, G., Oliver, S. G., Zhang, Z., George‐Hyslop, P. S., & Robertson, J. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.05.014 · Cited by 24 · see citing works
Chandley, M. J., Crawford, J. D., Szebeni, A., Szebeni, K., & Ordway, G. A. (2015) · Molecular Autism · doi:10.1186/s13229-015-0023-2 · Cited by 22 · see citing works
Single-cell qPCR on dispersed primary pituitary cells -an optimized protocol
Hodne, K., Haug, T. M., & Weltzien, F. (2010) · BMC Molecular Biology · doi:10.1186/1471-2199-11-82 · Cited by 21 · see citing works
Gene expression profiling in neurological disorders
Baranzini, S. (2007) · Neuromolecular medicine · doi:10.1385/nmm:6:1:031 · Cited by 17 · see citing works
Papapetropoulos, S., Shehadeh, L. A., & McCorquodale, D. S. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21355 · Cited by 20 · see citing works
Ginsberg, S. D. (2005) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200512000-00004 · Cited by 21 · see citing works
Self-citationCocainomics: New Insights into the Molecular Basis of Cocaine Addiction
Hemby, S. E. (2010) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9189-8 · Cited by 19 · see citing works
Self-citationMcClain, K. L., Cai, Y., Hicks, J. M., Peterson, L. E., Yan, X., Che, S., & Ginsberg, S. D. (2005) · Amino Acids · doi:10.1007/s00726-005-0177-x · Cited by 19 · see citing works
Self-citationGut Microbes Associated with Neurodegenerative Disorders: A Comprehensive Review of the Literature
Koutsokostas, C., Merkouris, E., Goulas, A., Aidinopoulou, K., Sini, N., Dimaras, T., Tsiptsios, D., Mueller, C., Nystazaki, M., & Tsamakis, K. (2024) · Microorganisms · doi:10.3390/microorganisms12081735 · Cited by 17 · see citing works
Gene Expression Analysis Using Conventional and Imaging Methods
Kadam, U. S., Lossie, A. C., Schulz, B., & Irudayaraj, J. (2013) · RNA technologies · doi:10.1007/978-3-642-36853-0_6 · Cited by 16 · see citing works
Counts, S., Perez, S. E., He, B., & Mufson, E. J. (2014) · Current Alzheimer Research · doi:10.2174/1567205011666140812114037 · Cited by 16 · see citing works
Self-citationTranscriptome Analysis of Single Cells
Morris, J. F., Singh, J. M., & Eberwine, J. H. (2011) · Journal of Visualized Experiments · doi:10.3791/2634-v · Cited by 14 · see citing works
Self-citationExpression Profile Analysis of Brain Aging
Ginsberg, S. D. (2007) · CRC Press eBooks · doi:10.1201/9781420005523-7 · Cited by 15 · see citing works
Self-citationGinsberg, S. D. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-3826-1 · Cited by 14 · see citing works
Self-citationDeciphering Drug Targets and Actions with Single-Cell and Spatial Resolution
Pang, Z., Cravatt, B. F., & Li, Y. (2023) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-033123-123610 · Cited by 10 · see citing works
Human glial cell culture models of inflammation in the central nervous system
van Noort, J. M. (2006) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03661-5 · Cited by 10 · see citing works
Yaron, J. R., Ziegler, C. P., Tran, T. H., Glenn, H. L., & Meldrum, D. R. (2014) · Biological Procedures Online · doi:10.1186/1480-9222-16-9 · Cited by 9 · see citing works
Microarray Technology for Mutation Analysis of Low-Template DNA Samples
Salvado, C. L., & Cram, D. S. (2007) · Methods in molecular medicine · doi:10.1007/978-1-59745-298-4_13 · Cited by 8 · see citing works
Choy, Y., Hong, S.-Y., Pack, S.-J., Woo, R., Baik, T., & Song, D. (2015) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2015.03.003 · Cited by 7 · see citing works
mRNA methods used in dissecting gene expression of the brain
Kannanayakal, T. J., & Eberwine, J. H. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.09.001 · Cited by 7 · see citing works
Self-citationBernstein, H., Kirches, E., Bogerts, B., Lendeckel, U., Keilhoff, G., Zempeltzi, M. M., Steiner, J. H., Tenbrock, K., Dobrowolny, H., Kyttaris, V. C., et al. (2013) · Amino Acids · doi:10.1007/s00726-013-1601-2 · Cited by 6 · see citing works
Microarray expression profiling in 6-hydroxydopamine-induced dopaminergic neuronal cell death
Park, B., Oh, C.-K., Choi, W.-S., Chung, I. K., Youdim, M. B. H., & Oh, Y. J. (2011) · Journal of Neural Transmission · doi:10.1007/s00702-011-0710-x · Cited by 6 · see citing works
Euler, P., Friedrich, B., Ziegler, R., Kuhn, A., Lindenberg, K. S., Weiller, C., & Zucker, B. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.03.080 · Cited by 6 · see citing works
Antisense RNA Amplification for Target Assessment of Total mRNA from a Single CellPreprint
Morris, J. F., Bell, T. J., Buckley, P. T., & Eberwine, J. H. (2014) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot072454 · Cited by 5 · see citing works
Self-citationImplications for the practice of psychiatry
Binder, E. B., & Nemeroff, C. B. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)58013-6 · Cited by 3 · see citing works
Biomarker Discovery in Major Psychiatric Disorders: Approaches, Limitations, and Future Directions
Bousman, A., Chana, G., Tatro, Glatt, Tsuang, M. T., & Everall, I. (2009) · Cited by 3 · see citing works
Gene Expression Analysis Using Conventional and Imaging Methods
Kadam, U. S., Lossie, A. C., Schulz, B., & Irudayaraj, J. (2013) · Springer eBooks · doi:10.1007/978-3-662-45775-7_6 · Cited by 3 · see citing works
Single-Cell and Regional Gene Expression Analysis in Alzheimer’s Disease
Kwong, R., Lupton, M. K., & Janitz, M. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9797-3 · Cited by 2 · see citing works
Transcriptional Changes in Alzheimer’s Disease
Miller, J. A., & Geschwind, D. H. (2010) · Systems biology · doi:10.1007/978-1-4419-5797-9_25 · Cited by 2 · see citing works
Long Non-coding RNAs in a Single-Cell Type: Function and Subcellular Localization
Bonadio, R. S., Alessio, E., & Cagnin, S. (2020) · RNA technologies · doi:10.1007/978-3-030-44743-4_4 · Cited by 2 · see citing works
Alzheimer's neuropathology in Down syndrome: From gestation to old age
Mufson, E. J., Miguel, J. C., & Perez, S. E. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818845-3.00011-6 · Cited by 2 · see citing works
Self-citationProblems for Structure Learning Aggregation and Computational Complexity
Wimberly, F., Danks, D. J., Glymour, C., & Chu, T. (2011) · IGI Global eBooks · doi:10.4018/978-1-60960-818-7.ch701 · Cited by 2 · see citing works
Sanna, P. P., Repunte‐Canonigo, V., & Guidotti, A. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-458-2_34 · Cited by 2 · see citing works
Problems for Structure Learning
Wimberly, F., Danks, D. J., Glymour, C., & Chu, T. (2010) · IGI Global eBooks · doi:10.4018/978-1-60566-685-3.ch013 · Cited by 2 · see citing works
Miller, J. A., & Geschwind, D. H. (2008) · Wiley eBooks · doi:10.1002/9783527622467.ch1
Molecular Neurobiology, Single-Cell
Spaethling, J. M., Rozak, E., & Eberwine, J. H. (2006) · Encyclopedia of Molecular Cell Biology and Molecular Medicine · doi:10.1002/3527600906.mcb.200400109
Self-citationM E T H O D S I N M O L E C U L A R M E D I C I N E
Soares, M. J., Hunt, J. S., Brooks, S. A., Harris, A. L., Davy, C. E., Carr, D. J., Johnson, P., Joos, T. O., Fortina, P. M., Sabatini, M., et al. (2005)
Studies of the global gene expression changes in alcoholic human brain and blood
Liu, J. (2005) · Texas ScholarWorks (Texas Digital Library)
Gene Arrays: A Practical Approach to Studying Stroke with Microarray
Gilbert, R. W., Costain, W. J., & Robertson, H. A. (2006) · Springer eBooks · doi:10.1007/978-0-387-30401-4_18
Ion Flux Regulates Inflammasome Signaling
Yaron, J. R. (2015) · doi:10.13140/rg.2.2.32297.60007
McKeever, P. M. (2018) · TSpace (University of Toronto)
Shukla, S. M. (2019) · Springer eBooks · doi:10.1007/978-3-319-47829-6_1337-1
Shukla, S. M. (2022) · Springer eBooks · doi:10.1007/978-3-319-55065-7_1337
Ibargüen-Vargas, Y. (2008) · theses.fr (ABES) · doi:10.70675/2d73c017z46fcz4c35z8397zb504072e069a
Reduction in Sample Heterogeneity Leads to Increased Microarray Sensitivity
Williams, A. J., Hagan, K. W., Culp, S. G., Medd, A. M., Mrzljak, L., Defay, T. R., & Mallamaci, M. A. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-328-8_5
- Authors
- Ginsberg, S. D., Elarova, I., Ruben, M., Tan, F., Counts, S. E., Eberwine, J. H., Trojanowski, J. Q., Hemby, S. E., Mufson, E. J., & Che, S.
- Affiliations
- New York University (US)
- Nathan Kline Institute for Psychiatric Research (US)
- Rush University Medical Center (US)
- University of Pennsylvania (US)
- Emory University (US)
- Corresponding author
- Ginsberg, Stephen D.
- ORCID
- Venue
- Neurochemical Research
- Published
- 2004-06
- Volume
- 29
- Issue
- 6
- Pages
- 1053-1064
- ISSN
- 0364-3190 (ISSN-L)
- 1573-6903
- OpenAlex
- W2111247490
- Cited by
- 97
- References
- 107
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2015: 5 · 2014: 4 · 2013: 5 · 2012: 2
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Neurochemical Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (AG9900, AG 10161, AG-14449, AG09215, P01AG014449, AG021661, R01AG021661, P30AG010124, P01AG009215, AG09466, AG-10124, P30AG010161, AG 10668, R01AG043375, P01AG009466, R01AG010668)
- National Institute of Mental Health (MH 43880)
- National Cancer Institute (R21CA094520, CA94520)
- National Institute of Neurological Disorders and Stroke (NS43939, R01NS043939)
- NIH Clinical Center
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Molecular Biology Techniques and Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- single-cell gene expression, neurodegenerative diseases, neuropsychiatric disorders, Alzheimer's disease, schizophrenia, central nervous system, neuronal subpopulations, postmortem brain, animal models, gene expression profiling
- MeSH terms
- Cell Physiological Phenomena, Humans, Neurons, Receptors, Dopamine, Schizophrenia, Gene Expression, Prosencephalon, Neurodegenerative Diseases, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review