Clinical significance and comorbidity of subthreshold depression and anxiety in the community
Abstract
OBJECTIVE: This report examines: 1) the magnitude of co-occurrence of threshold and subthreshold-level depression and anxiety in the community, and 2) the relationship between comorbidity and the diagnostic level of depression and anxiety and their clinical correlates. METHOD: A community sample of 591 subjects was interviewed prospectively five times across 15 years from the ages of 20-35. The diagnostic interview allowed the assignment of diagnoses according to DSM-III criteria and operational definitions of subthreshold syndromes. RESULTS: 1) Comorbidity between depression and anxiety was more frequent when one syndrome reached threshold level; 2) comorbidity at both the threshold and subthreshold diagnostic levels was associated with symptom severity, disability and treatment, whereas the diagnostic level was associated with disability and suicidal attempts. CONCLUSION: The systematic association between comorbidity across diagnostic threshold levels of anxiety and depression with clinical correlates suggests the importance of a more dimensional approach to their classification.
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Subthreshold symptoms may be associated with maladaptive functioning.
“Our findings demonstrate a notable portion of fathers experience subthreshold levels of internalizing problems, which might be overlooked despite the fact that subthreshold symptoms may be associated with maladaptive functioning [92].”
From Trajectories of Maternal and Paternal Internalizing Symptoms from Pregnancy to 2 Years Postpartum: Identifying Modifiable Risk and Protective Factors (2024) · cites this paper as [92]
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- Authors
- Preisig, M., Merikangas, K. R., & Angst, J.
- Affiliations
- University of Lausanne (CH)
- Yale University (US)
- Psychiatrische Universitätsklinik Zürich (CH)
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2001-08
- Volume
- 104
- Issue
- 2
- Pages
- 96-103
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W2094870250
- Cited by
- 145
- References
- 33
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 8 · 2019: 8 · 2018: 6 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 8 · 2013: 4 · 2012: 6
- FWCI
- 8.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- Systematics Association
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- U.S. Public Health Service (KO2-0499)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- subthreshold depression, subthreshold anxiety, comorbid depression and anxiety, dimensional classification, symptom severity, disability, suicide attempts, community mental health, young adults
- MeSH terms
- Adult, Anxiety Disorders, Depressive Disorder, Diagnosis, Differential, Female, Humans, Longitudinal Studies, Male, Comorbidity, Incidence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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