Immediate effects of UV radiation on the skin: Modification by an antioxidant complex containing carotenoids
Open accessAbstract
BACKGROUND/AIMS: The ultraviolet (UV) portion of sunlight is involved in the induction and development of skin cancers against which a limited photoprotection may be provided by reduced time of exposure, clothing, and sunscreen applications. The concept of an effective, safe, systemic photoprotection will circumvent many of the shortcomings. The UV-induced oxidative stress is a cause of DNA damage and a few publications have shown, in humans, minimal benefits, if any, of the oral intake of antioxidant complex, contrasting with the large literature showing beneficial effects in vitro or in animal models. METHODS: We investigated, in 25 healthy individuals, the capacity of an antioxidant complex (AOC) - vitamins (lycopene, beta-carotene, alpha-tocopherol), selenium - to reduce UV-induced damages. The AOC was administered orally, daily during 7 weeks. Before and after irradiations, before and after the intake of the product, six parameters were studied: skin color by chromametry, minimal erythemal dose and, on skin biopsies, sunburn cells (SBCs), p53 detected by immunohistochemistry, pigmentation index, and levels of lipoperoxides (thiobarbituric acid reaction). RESULTS: After the oral intake of AOC, we observed an elevation of the actinic erythema threshold (+20%, P=0.01) and a general reduction of the UV-induced erythemas, a reduction of the UV-induced p53 expression (P<0.05) and of SBCs (P<0.01), and a parallel reduction of the lipoperoxide levels (P<0.01). The pigmentation was increased (P<0.01). CONCLUSION: After the oral intake of an antioxidant complex, many parameters of the epidermal defense against UV-induced damages are significantly improved. The oral intake of AOC could provide a safe, daylong and efficient complement to photo-protective measures provided by topical and physical agents and may contribute to reduce the DNA damages leading to skin aging and skin cancers.
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Carotenoids in the diet and in the form of dietary supplements have photoprotective effects.
“Research confirms the photoprotective effects of carotenoids in the diet and in the form of dietary supplements.”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [238]
After 6 weeks of oral application of an antioxidant complex consisting of β-carotene, lycopene, selenium and α-tocopherol, protection against UV-induced skin damage increases.
“After 6 weeks of the application of the antioxidants, an increase in protection against UV-induced skin damage was observed, accompanied by a reduction in lipoperoxide levels and sunburn cells (SBCs), as well as an increase in skin pigmentation [238].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [238]
After 6 weeks of oral application of an antioxidant complex consisting of β-carotene, lycopene, selenium and α-tocopherol, sunburn cells (SBCs) are reduced.
“After 6 weeks of the application of the antioxidants, an increase in protection against UV-induced skin damage was observed, accompanied by a reduction in lipoperoxide levels and sunburn cells (SBCs), as well as an increase in skin pigmentation [238].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [238]
After 6 weeks of oral application of an antioxidant complex consisting of β-carotene, lycopene, selenium and α-tocopherol, skin pigmentation increases.
“After 6 weeks of the application of the antioxidants, an increase in protection against UV-induced skin damage was observed, accompanied by a reduction in lipoperoxide levels and sunburn cells (SBCs), as well as an increase in skin pigmentation [238].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [238]
After 6 weeks of oral application of an antioxidant complex consisting of β-carotene, lycopene, selenium and α-tocopherol, lipoperoxide levels are reduced.
“After 6 weeks of the application of the antioxidants, an increase in protection against UV-induced skin damage was observed, accompanied by a reduction in lipoperoxide levels and sunburn cells (SBCs), as well as an increase in skin pigmentation [238].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [238]
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- Authors
- Césarini, J. P., Michel, L., Maurette, J. M., Adhoute, H., & Béjot, M.
- Affiliations
- Fondation Ophtalmologique Adolphe de Rothschild (FR)
- Inserm (FR)
- Oenobiol (France) (FR)
- Corresponding author
- Césarini, J. P.
- ORCID
- Michel, L.
- Venue
- Photodermatology, Photoimmunology & Photomedicine
- Publisher
- Wiley
- Published
- 2003-08
- Volume
- 19
- Issue
- 4
- Pages
- 182-189
- ISSN
- 0905-4383 (ISSN-L)
- 1600-0781
- OpenAlex
- W2138188139
- Cited by
- 143
- References
- 30
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 7 · 2022: 7 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 7 · 2017: 6 · 2016: 5 · 2015: 3 · 2014: 10 · 2013: 4 · 2012: 6
- FWCI
- 5.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Photodermatology Photoimmunology & Photomedicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- ultraviolet radiation, photoprotection, antioxidant complex, carotenoids, lycopene, beta-carotene, alpha-tocopherol, selenium, oxidative stress, sunburn cells, p53, minimal erythema dose, lipid hydroperoxides, skin pigmentation, DNA damage, skin cancer prevention, skin aging
- MeSH terms
- Lycopene, Administration, Oral, Adult, Analysis of Variance, Antioxidants, Carotenoids, Drug Therapy, Combination, Female, Humans, Immunoenzyme Techniques, Male, Selenium, Skin, Sunburn, Ultraviolet Rays, Skin Aging, Treatment Outcome
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