Cited by 189Smoking Behavior and CessationSubstance Abuse Treatment and OutcomesPrenatal Substance Exposure Effects

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Profiles in discouragement: Two studies of variability in the time course of smoking withdrawal symptoms.

Piasecki, Thomas M., Fiore, Michael C., Baker, Timothy B.·1998·Journal of Abnormal Psychology

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Abstract

Research has suggested that the time course of the smoking withdrawal syndrome is fairly invariant across smokers and that smoking withdrawal symptoms are weakly related to relapse. Withdrawal data from 2 clinical trials of the nicotine patch were analyzed to evaluate these characterizations. In both studies, patients were clustered according to the shapes of their withdrawal profiles across 8 weeks of treatment. In each study, 3 clusters with distinct temporal patterns of withdrawal symptomatology emerged. Clusters included both abstinent and lapsing patients, and patch dose was unrelated to cluster membership. Patients with "atypical" patterns of smoking withdrawal (e.g., late symptomatic elevations) were more likely to relapse than patients who showed a gradual elimination of withdrawal. Withdrawal shape, duration, and severity all contributed significantly to the prediction of relapse. Measures of negative affect closely tracked withdrawal symptoms over time within clusters. Topics for future smoking withdrawal research are discussed.

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Authors: Piasecki, T. M., Fiore, M. C., & Baker, T. B.
Affiliations: University of Wisconsin–Madison (US)
ORCID: Piasecki, Thomas M.
Fiore, Michael C.
Venue: Journal of Abnormal Psychology
Publisher: American Psychological Association (APA)
Published: 1998-05
Volume: 107
Issue: 2
Pages: 238-251
ISSN: 0021-843X (ISSN-L)
1939-1846
DOI: 10.1037/0021-843x.107.2.238
OpenAlex: W1968910627
Cited by: 189
References: 69
Citations by year: 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 6 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 9 · 2015: 4 · 2014: 10 · 2013: 7 · 2012: 9
FWCI: 2.11
Type: journal article
Language: en
Open access: closed
Locations: Journal of Abnormal Psychology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01da007580-04)
National Institute on Drug Abuse (R01-DA07580-03)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords: smoking withdrawal symptoms, nicotine patch, recurrence prediction, nicotine dependence, negative affect, smoking cessation, nicotine replacement therapy
MeSH terms: Administration, Cutaneous, Adult, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Middle Aged, Nicotine, Recurrence, Smoking, Substance Withdrawal Syndrome, Smoking Cessation

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Profiles in discouragement: Two studies of variability in the time course of smoking withdrawal symptoms.

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