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Profiles in discouragement: Two studies of variability in the time course of smoking withdrawal symptoms.
Abstract
Research has suggested that the time course of the smoking withdrawal syndrome is fairly invariant across smokers and that smoking withdrawal symptoms are weakly related to relapse. Withdrawal data from 2 clinical trials of the nicotine patch were analyzed to evaluate these characterizations. In both studies, patients were clustered according to the shapes of their withdrawal profiles across 8 weeks of treatment. In each study, 3 clusters with distinct temporal patterns of withdrawal symptomatology emerged. Clusters included both abstinent and lapsing patients, and patch dose was unrelated to cluster membership. Patients with "atypical" patterns of smoking withdrawal (e.g., late symptomatic elevations) were more likely to relapse than patients who showed a gradual elimination of withdrawal. Withdrawal shape, duration, and severity all contributed significantly to the prediction of relapse. Measures of negative affect closely tracked withdrawal symptoms over time within clusters. Topics for future smoking withdrawal research are discussed.
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“Indeed, withdrawal duration and severity predict relapse in abstinent human smokers (Piasecki et al. 1998(Piasecki et al. , 2000(Piasecki et al. , 2003)).”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Piasecki et al. 1998
In the citing paper
“In studies using Ecological Momentary Assessment (EMA) to measure real-time data in the natural environment, the severity of NA and craving are highly predictive of smoking lapse and relapse during abstinence (McCarthy, Piasecki, Fiore, & Baker, 2006; Piasecki et al., 2000; Piasecki, Fiore, & Baker, 1998; Piper, Loh, Smith, Japuntich, & Baker, 2011; Shiffman, 2005; Shiffman et al., 1997, 2007).”
From Modeling naturalistic craving, withdrawal, and affect during early nicotine abstinence: A pilot ecological momentary assessment study. (2015) · cites this paper as Piasecki, Fiore, & Baker, 1998
In the citing paper
“in the context of fine-grained analyses withdrawal indeed can predict relapse [64,65].”
From Relapse prevention for addictive behaviors (2011) · cites this paper as [65]
In the citing paper
“The symptoms associated with nicotine withdrawal are a primary deterrent to cessation and they need to be quelled to avoid early relapse.”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [26]
In the citing paper
“Symptoms of greater intensity, positive slope and variability have been observed to predict relapse to smoking (45, 46) and symptoms of craving and negative affect were the most likely to be associated with relapse (47, 48).”
From Tobacco addiction (2008) · cites this paper as [45]
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Metadata
- Authors
- Piasecki, T. M., Fiore, M. C., & Baker, T. B.
- Affiliations
- University of Wisconsin–Madison (US)
- Venue
- Journal of Abnormal Psychology
- Published
- 1998-05
- Volume
- 107
- Issue
- 2
- Pages
- 238-251
- ISSN
- 0021-843X (ISSN-L)
- 1939-1846
- OpenAlex
- W1968910627
- Cited by
- 189
- References
- 69
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 6 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 9 · 2015: 4 · 2014: 10 · 2013: 7 · 2012: 9
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Abnormal Psychology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01da007580-04)
- National Institute on Drug Abuse (R01-DA07580-03)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- smoking withdrawal symptoms, nicotine patch, recurrence prediction, nicotine dependence, negative affect, smoking cessation, nicotine replacement therapy
- MeSH terms
- Administration, Cutaneous, Adult, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Middle Aged, Nicotine, Recurrence, Smoking, Substance Withdrawal Syndrome, Smoking Cessation
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