Smoking withdrawal dynamics: III. Correlates of withdrawal heterogeneity
Abstract
Five parameters of postcessation smoking withdrawal variability derived from clinical data (T. M. Piasecki, D. E. Jorenby, S. S. Smith, M. C. Fiore, & T. B. Baker, 2003a, 2003b) were predicted from baseline measures and pharmacotherapy assignment. Smokers who were more dependent, older, and high in negative affect reported more severe withdrawal. Women, heavier smokers, and those with a history of depression reported more variable symptoms. Smokers treated with nicotine patch, bupropion, or both reported less severe withdrawal than did those given placebo, but medication did not affect the slope of symptoms over time, day-to-day variability of symptoms, or the size of acute changes in symptoms associated with lapses to smoking. Prior research has shown that these symptom facets predict later relapse: thus, current pharmacotherapies may aid cessation by diminishing withdrawal severity, but they do not affect all clinically important aspects of withdrawal.
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Increased severity of nicotine withdrawal predicts increased relapse rates.
“Nicotine withdrawal symptoms are highly variable between patients and can be quite severe, with increased severity of withdrawal being predictive of increased rates of relapse [25, 27, 128–130].”
From Mechanistic insights into nicotine withdrawal (2011) · cites this paper as [129]
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- Authors
- Piasecki, T. M., Jorenby, D. E., Smith, S. S., Fiore, M. C., & Baker, T. B.
- Affiliations
- University of Missouri (US)
- University of Wisconsin–Madison (US)
- Venue
- Experimental and Clinical Psychopharmacology
- Published
- 2003
- Volume
- 11
- Issue
- 4
- Pages
- 276-285
- ISSN
- 1064-1297 (ISSN-L)
- 1936-2293
- OpenAlex
- W1999157638
- Cited by
- 104
- References
- 40
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2020: 26 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 3 · 2013: 7 · 2012: 6
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental and Clinical Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01da007580-04)
- National Institute on Drug Abuse (DA07580-03)
- National Cancer Institute (CA84724-02, P50CA084724)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- nicotine withdrawal, nicotine dependence, nicotine patch, bupropion, nicotine replacement therapy, smoking cessation, smoking relapse, negative affect, history of depression, smoking lapse
- MeSH terms
- Administration, Cutaneous, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Nicotine, Predictive Value of Tests, Psychiatric Status Rating Scales, Recurrence, Severity of Illness Index, Smoking, Substance Withdrawal Syndrome, Time Factors, Tobacco Use Disorder, Chi-Square Distribution, Smoking Cessation, Bupropion, Treatment Outcome, Nicotinic Agonists, Dopamine Uptake Inhibitors
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