Cited by 334Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychotherapy Techniques and ApplicationsTreatment of Major Depression

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Comparative outcomes for individual cognitive-behavior therapy, supportive-expressive group psychotherapy, and sertraline for the treatment of depression in multiple sclerosis.

Mohr, David C., Boudewyn, Arne C., Goodkin, Donald E., Bostrom, Alan, Epstein, Lucy·2001·Journal of Consulting and Clinical Psychology

DOI 10.1037/0022-006x.69.6.942

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Abstract

This study compared the efficacy of 3 16-week treatments for depression in 63 patients with multiple sclerosis (MS) and major depressive disorder (MDD): individual cognitive-behavioral therapy (CBT), supportive-expressive group therapy (SEG). and the antidepressant sertraline. Significant reductions were seen from pre- to posttreatment in all measures of depression. Intent-to-treat and completers analyses using the Beck Depression Inventory (BDI; A. T. Beck, C. H. Ward. M. Medelson. J. Mock, & J. Erbaugh, 1961) and MDD diagnosis found that CBT and sertraline were more effective than SEG at reducing depression. These results were largely supported by the BDI-18, which eliminates BDI items confounded with MS. However, the Hamilton Rating Scale for Depression (M. Hamilton, 1960) did not show consistent differences between treatments. Reasons for this inconsistency are discussed. These findings suggest that CBT or sertraline is more likely to be effective in treating MDD in MS compared with supportive group treatments.

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Authors: Mohr, D. C., Boudewyn, A. C., Goodkin, D. E., Bostrom, A., & Epstein, L.
Affiliations: University of California, San Francisco (US)
Kaiser Permanente (US)
University of California Office of the President (US)
ORCID: Mohr, David C.
Venue: Journal of Consulting and Clinical Psychology
Publisher: American Psychological Association (APA)
Published: 2001
Volume: 69
Issue: 6
Pages: 942-949
ISSN: 0022-006X (ISSN-L)
1939-2117
DOI: 10.1037/0022-006x.69.6.942
OpenAlex: W2028940268
Cited by: 334
References: 84
Citations by year: 2026: 7 · 2025: 4 · 2024: 4 · 2023: 9 · 2022: 2 · 2021: 9 · 2020: 11 · 2019: 11 · 2018: 8 · 2017: 24 · 2016: 19 · 2015: 20 · 2014: 13 · 2013: 24 · 2012: 23
FWCI: 13.49
Type: journal article
Language: en
Open access: closed
Locations: Journal of Consulting and Clinical Psychology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (R01-MH59708, R01MH059708)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: depression, multiple sclerosis, major depressive disorder, cognitive behavioral therapy, supportive-expressive group therapy, sertraline, antidepressant treatment, treatment efficacy comparison, Beck Depression Inventory, Hamilton Depression Rating Scale
MeSH terms: Major Depressive Disorder, Depressive Disorder, Major, Female, Humans, Male, Multiple Sclerosis, Psychotherapy, Group, Surveys and Questionnaires, Cognitive Behavioral Therapy, Selective Serotonin Reuptake Inhibitors, Sertraline

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Comparative outcomes for individual cognitive-behavior therapy, supportive-expressive group psychotherapy, and sertraline for the treatment of depression in multiple sclerosis.

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