Rhinal cortex ablations fail to disrupt reinforcer devaluation effects in rhesus monkeys (Macaca mulatta).
Abstract
Studies have shown that excitotoxic lesions of the amygdala attenuate reinforcer devaluation effects in monkeys and rats. Because the rhinal (i.e., entorhinal and perirhinal) cortex has prominent reciprocal connections with the amygdala and has been suggested to store knowledge about objects, it is possible that it too composes part of the critical circuitry subserving learning about objects and their associated reinforcement value. To test this possibility, rhesus monkeys with rhinal cortex removals as well as unoperated controls were tested using a reinforcer devaluation procedure. Monkeys with rhinal cortex removals and controls, unlike those with amygdala lesions, tended to avoid displacing objects overlying a devalued food. These results indicate that the rhinal cortex is not a critical part of the neural circuitry mediating the effects of reinforcer devaluation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Damage to regions near the amygdala, such as entorhinal cortex, perirhinal cortex, or hippocampus, has no effect on the devaluation task.
“Likewise, damage to regions near the amygdala, such as the entorhinal cortex, perirhinal cortex, or hippocampus, have no effect (81, 82).”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [82]
Cites
Handbook of Sensory Physiology
Sanders, M. D. (1975) · British Journal of Ophthalmology · doi:10.1136/bjo.59.2.111-c · Cited by 7,166 · see citing works
Squire, L. R. (1984) · Springer eBooks · doi:10.1007/978-3-642-70094-1_32 · Cited by 2,126 · see citing works
Contemporary Animal Learning Theory
LoLordo, V. M., & Dickinson, A. (1982) · The American Journal of Psychology · doi:10.2307/1422669 · Cited by 891 · see citing works
Marburg, O. (2007) · Stereotactic and Functional Neurosurgery · doi:10.1159/000105833 · Cited by 387 · see citing works
Flagged first, then by citations
1 of the 5 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Baxter, M. G., & Murray, E. A. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn875 · Cited by 1,200 · see citing works
Self-citationBaxter, M. G., Parker, A., Lindner, C. C. C., Izquierdo, A. D., & Murray, E. A. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04311.2000 · Cited by 582 · see citing works
Self-citationNeural systems and cue-induced cocaine craving
Bonson, K. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00371-2 · Cited by 507 · see citing works
Role of perirhinal cortex in object perception, memory, and associations
Murray, E. A., & Richmond, B. J. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00195-1 · Cited by 319 · see citing works
Self-citationLocalization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala
Murray, E. A., Wise, S. P., & Drevets, W. C. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.041 · Cited by 208 · see citing works
Self-citationTransient Inactivation of Orbitofrontal Cortex Blocks Reinforcer Devaluation in Macaques
West, E. A., DesJardin, J. T., Gale, K., & Málková, L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3295-11.2011 · Cited by 137 · see citing works
Liu, Z., & Richmond, B. J. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.3.1677 · Cited by 134 · see citing works
GABA<sub>A</sub>-Mediated Inhibition of Basolateral Amygdala Blocks Reward Devaluation in Macaques
Wellman, L. L., Gale, K., & Malkova, L. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2257-04.2005 · Cited by 126 · see citing works
Machado, C. J., & Bachevalier, J. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05525.x · Cited by 120 · see citing works
The neurocognitive bases of human multimodal food perception: Consciousness
Verhagen, J. V. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.09.002 · Cited by 109 · see citing works
Mitchell, A. S., Browning, P. G. F., & Baxter, M. G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1914-07.2007 · Cited by 100 · see citing works
Learning motivational significance of visual cues for reward schedules requires rhinal cortex
Liu, Z., Murray, E. A., & Richmond, B. J. (2000) · Nature Neuroscience · doi:10.1038/81841 · Cited by 95 · see citing works
Self-citationNeural Estimates of Imagined Outcomes in the Orbitofrontal Cortex Drive Behavior and Learning
Takahashi, Y. K., Chang, C. Y., Lucantonio, F., Haney, R. Z., Berg, B. A., Yau, H., Bonci, A., & Schoenbaum, G. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.008 · Cited by 81 · see citing works
Amount of training affects associatively-activated event representation
Holland, P. C. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00038-0 · Cited by 75 · see citing works
Baxter, M. G., & Murray, E. A. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01491.x · Cited by 69 · see citing works
Self-citationMurray, E. A., & Wise, S. P. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.05.005 · Cited by 45 · see citing works
Self-citationBachevalier, J., Machado, C. J., & Kazama, A. M. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06211.x · Cited by 39 · see citing works
Machado, C. J., & Bachevalier, J. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.06.035 · Cited by 35 · see citing works
Clark, A. M., Bouret, S., Young, A. M., Murray, E. A., & Richmond, B. J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3605-12.2013 · Cited by 31 · see citing works
Self-citationCognitive Aging in Nonhuman Primates
Baxter, M. G. (2001) · Elsevier eBooks · doi:10.1016/b978-012351830-9/50028-7 · Cited by 24 · see citing works
Eldridge, M. A. G., Hines, B. E., & Murray, E. A. (2021) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2021.02.012 · Cited by 21 · see citing works
Self-citationCognitive functions of the temporal lobe in the dog: A review
Kowalska, D. M. (2000) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(00)00110-x · Cited by 20 · see citing works
Ridley, R., Warner, K. A., Maclean, C. J., Gaffan, D., & Baker, H. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02187-4 · Cited by 20 · see citing works
Baxter, M. G., Hadfield, W. S., & Murray, E. A. (1999) · Behavioral Neuroscience · doi:10.1037//0735-7044.113.2.243 · Cited by 19 · see citing works
Self-citationA visual, position-independent instrumental reinforcer devaluation task for rats
West, E. A., Forcelli, P. A., Murnen, A. T., Gale, K., & Málková, L. (2010) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2010.11.004 · Cited by 15 · see citing works
Macaques fail to develop habit responses during extended training on a reinforcer devaluation task.
LaFlamme, E. M., Ahmed, F., Forcelli, P. A., & Málková, L. (2022) · Behavioral Neuroscience · doi:10.1037/bne0000503 · Cited by 9 · see citing works
Functional neuroanatomy of human emotion
Morris, J. C., & Dolan, R. (2003) · Elsevier eBooks · doi:10.1016/b978-012264841-0/50020-2 · Cited by 11 · see citing works
Eacott, M. J., Norman, G., & Gaffan, E. A. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.6.1318 · Cited by 8 · see citing works
Effects of systemic cholinergic antagonism on reinforcer devaluation in macaques
Waguespack, H. F., Málková, L., Forcelli, P. A., & Turchi, J. N. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.05.003 · Cited by 7 · see citing works
Kowalska, D. M. (1999) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-1999-1315 · Cited by 7 · see citing works
Temporal-orbitofrontal pathway regulates choices across physical reward and visual novelty
Ogasawara, T., Xu, K., Snyder, A. Z., Perlmutter, J. S., Tu, Z., Minamimoto, T., Inoue, K., Takada, M., & Monosov, I. E. (2026) · Neuron · doi:10.1016/j.neuron.2025.12.011 · Cited by 2 · see citing works
Wang, W., Eldridge, M. A. G., Setogawa, T., Webster-Bass, S., Miyazaki, N. L., Pearl, J. E., Liow, J., Lerchner, W., Li, B., Turchi, J. N., et al. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.0491-25.2025
- Authors
- Thornton, J. A., Malkova, L., & Murray, E. A.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Murray, E. A.
- Venue
- Behavioral Neuroscience
- Published
- 1998
- Volume
- 112
- Issue
- 4
- Pages
- 1020-1025
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2049099656
- Cited by
- 32
- References
- 5
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 1 · 2021: 1 · 2018: 1 · 2013: 2
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- reinforcer devaluation, rhinal cortex, entorhinal cortex, perirhinal cortex, amygdala, excitotoxic lesions, object learning, avoidance behavior, rhesus monkeys
- MeSH terms
- Analysis of Variance, Animals, Appetitive Behavior, Association Learning, Cerebral Cortex, Discrimination Learning, Food, Limbic System, Macaca mulatta, Neural Pathways, Reinforcement, Psychology, Satiation, Entorhinal Cortex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review