Control of Response Selection by Reinforcer Value Requires Interaction of Amygdala and Orbital Prefrontal Cortex

Baxter, Mark G.; Parker, Amanda; Lindner, Caroline C. C.; Izquierdo, Alicia D.; Murray, Elisabeth A.

doi:10.1523/jneurosci.20-11-04311.2000

Cited by 582Neural and Behavioral Psychology StudiesMemory and Neural MechanismsNeurotransmitter Receptor Influence on Behavior

Control of Response Selection by Reinforcer Value Requires Interaction of Amygdala and Orbital Prefrontal Cortex

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Baxter, Mark G., Parker, Amanda, Lindner, Caroline C. C., Izquierdo, Alicia D., Murray, Elisabeth A.·2000·The Journal of Neuroscience

DOI 10.1523/jneurosci.20-11-04311.2000PMC PMC6772657

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Abstract

Goal-directed actions are guided by expected outcomes of those actions. Humans with bilateral damage to ventromedial prefrontal cortex, or the amygdala, are deficient in their ability to use information about positive and negative outcomes to guide their choice behavior. Similarly, rats and monkeys with orbital prefrontal or amygdala damage have been found to be impaired in their responses to changing values of outcomes. In the present study, we tested whether direct, functional interaction between the amygdala and the orbital prefrontal cortex is necessary for guiding behavior based on expected outcomes. Unlike control monkeys, rhesus monkeys with surgical disconnection of these two structures, achieved by crossed unilateral lesions of the amygdala in one hemisphere and orbital prefrontal cortex in the other, combined with forebrain commissurotomy, were unable to adjust their choice behavior after a change in the outcome (here, a reduction in the value of a particular reinforcer). The lesions did not affect motivation to work for a food reinforcer, or food preferences, per se. Hence, the amygdala and orbital prefrontal cortex act as part of an integrated neural system guiding decision-making and adaptive response selection.

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Animal studies show connectivity between the amygdala and orbital frontal cortex is important for assessing changes in emotional value of an object and adapting behavior accordingly.
“These findings are in accordance with animal studies (Baxter et al. 2000) which show connectivity between the amgydala and orbital frontal cortex are important for assessing changes in emotional value of an object and adapting behavior accordingly.”
From The Adolescent Brain (2008) · cites this paper as Baxter et al. 2000

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Authors: Baxter, M. G., Parker, A., Lindner, C. C. C., Izquierdo, A. D., & Murray, E. A.
Affiliations: Harvard University (US)
University of Nottingham (GB)
National Institutes of Health (US)
ORCID: Baxter, Mark G.
Izquierdo, Alicia D.
Murray, Elisabeth A.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2000-06-01
Volume: 20
Issue: 11
Pages: 4311-4319
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.20-11-04311.2000
PMC: PMC6772657
OpenAlex: W2110270116
Cited by: 582
References: 6
Citations by year: 2026: 2 · 2025: 9 · 2024: 9 · 2023: 13 · 2022: 15 · 2021: 21 · 2020: 13 · 2019: 15 · 2018: 17 · 2017: 22 · 2016: 24 · 2015: 17 · 2014: 16 · 2013: 20 · 2012: 24
FWCI: 16.26
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 183 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: amygdala, orbitofrontal cortex, response selection, reinforcer value, decision-making, goal-directed behavior, commissurotomy, lesion studies, rhesus monkeys, food reinforcement, motivation
MeSH terms: Accommodation, Ocular, Amygdala, Animals, Discrimination, Psychological, Food, Macaca mulatta, Male, Motivation, Reinforcement, Psychology, Reinforcement Schedule, Reward, Satiety Response, Prosencephalon, Prefrontal Cortex

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Control of Response Selection by Reinforcer Value Requires Interaction of Amygdala and Orbital Prefrontal Cortex

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