The effects of selective amygdala, orbital frontal cortex or hippocampal formation lesions on reward assessment in nonhuman primates
Abstract
We examined the effects of bilateral amygdaloid, hippocampal or orbital frontal cortex lesions on reward assessment in rhesus monkeys (Macaca mulatta). In Experiment 1, basic preferences for foods and inedible nonfoods were measured pre‐ and postsurgery. None of the lesions produced changes in animals' preferences for palatable foods or raw meat relative to presurgery, although amygdaloid or hippocampal lesions yielded increased preference for inedible nonfoods postsurgery. When the reinforcement value of each animal's highest‐preferred food was decreased by selective satiation, only animals with neurotoxic orbital frontal cortex lesions continued to select the sated food. Experiment 2 measured the impact of each lesion on learning 60 concurrent discrimination problems and, then, on flexibly avoiding objects associated with sated foods in favour of objects associated with nonsated foods. None of the lesions affected concurrent discrimination learning, but animals with neurotoxic amygdala or aspiration orbital frontal lesions could not refrain from displacing items covering devalued foods. Only animals with orbital lesions also selected the devalued food beneath the object. The results indicate a functional dissociation for the amygdala and orbital frontal cortex in reward assessment, depending on the type of the reinforcer available (objects vs. food). Finally, this is the first study indicating that the hippocampal formation is involved in the assessment of familiar nonfoods, but not in judging the current value of unconditioned and conditioned reinforcers.
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Damage to the OFC can result in hyperphagia.
“Indeed, damage to the OFC can result in hyperphagia (122,123).”
From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [122]
Dysfunction of the OFC has been linked to overeating.
“Indeed, dysfunction of the OFC has been linked to overeating (Machado and Bachevalier 2007).”
From Food and Drug Reward: Overlapping Circuits in Human Obesity and Addiction (2011) · cites this paper as Machado and Bachevalier 2007
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- Authors
- Machado, C. J., & Bachevalier, J.
- Affiliations
- The University of Texas Health Science Center at Houston (US)
- Emory University (US)
- Corresponding author
- Machado, Christopher J.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2007-05
- Volume
- 25
- Issue
- 9
- Pages
- 2885-2904
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W1622056134
- Cited by
- 120
- References
- 66
- Citations by year
- 2026: 2 · 2024: 3 · 2022: 5 · 2021: 7 · 2020: 5 · 2019: 4 · 2018: 6 · 2017: 6 · 2016: 6 · 2015: 4 · 2014: 6 · 2013: 10 · 2012: 8
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH058846, F31MH063577, MH-63577, MH 58846)
- National Center for Research Resources (RR-00 165, P51RR000165)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD035471, HD35471)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- amygdala, orbitofrontal cortex, hippocampal formation, rhesus monkeys, food preferences, satiation, currency devaluation, object displacement, avoidance learning, neurotoxic lesion, aspiration lesions, reinforcer value
- MeSH terms
- Amygdala, Animals, Appetite, Cognition, Cognition Disorders, Conditioning, Psychological, Denervation, Discrimination Learning, Feeding Behavior, Hippocampus, Learning Disabilities, Macaca mulatta, Male, Neural Pathways, Neurotoxins, Reward, Prefrontal Cortex
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