GABAA-Mediated Inhibition of Basolateral Amygdala Blocks Reward Devaluation in Macaques
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Amygdala ablation disrupts reinforcer “devaluation” in monkeys (Malkova et al., 1997). Here, we tested the hypothesis that transient inactivation of amygdala by the GABA A agonist muscimol (MUS), specifically during the period of reward satiation, would have a similar effect. Six pigtail macaques were trained on a visual object discrimination task in which 60 objects were associated with one of two specific food rewards. Subsequently, we evaluated the selective satiation-induced change (devaluation) in object preference in probe sessions. We also examined the effect of the amygdala inactivation during the probe sessions to determine whether the inactivation limited to the testing period (and not during the satiation period) is sufficient to impair the expression of reinforcer devaluation. MUS infusions were aimed at basolateral amygdala (BLA) in a pseudorandomized design; each monkey received MUS or saline either before or after selective satiation with each of the two food rewards (six infusions total). Under the control (saline) condition, the monkeys significantly shifted their preference from objects representing the sated food rewards to those representing the nonsated rewards (30% change). When BLA was inactivated during selective satiation (i.e., MUS infused before satiation), this devaluation effect was blocked. In contrast, MUS infusion after satiation, so that it was present just during the testing period, did not impair the shift in object preference (27% change). Thus, BLA is necessary for the appropriate registration of the change in the reinforcer value but not for the subsequent expression of the devaluation involving its transfer to secondary reinforcers.
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Reversible inactivation of the amygdala during selective satiation, but not afterward, attenuates the devaluation effect.
“Reversible inactivation of the amygdala during the selective satiation procedure, but not afterward, attenuates the devaluation effect (83).”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [83]
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- Authors
- Wellman, L. L., Gale, K., & Malkova, L.
- Affiliations
- Georgetown University (US)
- ORCID
- Wellman, Laurie L.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2005-05-04
- Volume
- 25
- Issue
- 18
- Pages
- 4577-4586
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6725040
- OpenAlex
- W2033299431
- Cited by
- 126
- References
- 53
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 11 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 7 · 2016: 7 · 2015: 10 · 2014: 5 · 2013: 8 · 2012: 9
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH67414, F31MH067414)
- National Institute of Neurological Disorders and Stroke (NS-20576, R01NS020576)
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K02HD042269, K02 HD42269, HD39937, R21HD039937)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- basolateral amygdala, reward devaluation, muscimol, GABAA receptor, reinforcer value, object preference, secondary reinforcers, macaque, object discrimination
- MeSH terms
- Amygdala, Analysis of Variance, Animals, Behavior, Animal, Choice Behavior, Discrimination, Psychological, Eating, Extinction, Psychological, Infusion Pumps, Inhibition, Psychological, Macaca nemestrina, Magnetic Resonance Imaging, Muscimol, Receptors, GABA-A, Reward, Satiation, Time Factors, GABA Agonists
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