Nucleus accumbens amphetamine microinjections unconditionally elicit 50-kHz ultrasonic vocalizations in rats
Abstract
The authors have hypothesized that, in adult rats, 50-kHz ultrasonic vocalizations (USVs) index a state characterized by high arousal and expectations of reward. This study was conducted to investigate whether dopamine agonism of the nucleus accumbens (NAcc) could evoke such an appetitive state, by examining the effects of NAcc amphetamine (AMPH) microinjections on USVs. Intra-NAcc AMPH injections (0.3, 1.0, 3.0, 10.0 microg unilaterally) produced robust, dose-dependent increases in 50-kHz USVs, which could not be accounted for by concomitant increases in locomotor activity (LA). However, AMPH injections into dorsal control caudate putamen sites produced a modest, dose-dependent increase in LA without significant increases in 50-kHz USVs. These findings indicate that NAcc AMPH microinjections selectively evoke 50-kHz USVs in rats, supporting the notion that dopamine elevations in the NAcc may unconditionally elicit a state of reward anticipation.
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Microinjections of amphetamine into the medial shell, more readily than the core, elicit high frequency (around 50-Hz) ultrasonic vocalizations, which have been implicated in positive motivational states in rats.
“Microinjections of amphetamine into the medial shell, more readily than the core, elicit high frequency (around 50-Hz) ultrasonic vocalizations (Burgdorf et al., 2001; Thompson et al., 2006), which have been implicated in positive motivational states in rats (Knutson et al., 2002).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Burgdorf et al., 2001
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- Authors
- Burgdorf, J., Knutson, B., Panksepp, J., & Ikemoto, S.
- Affiliations
- National Institutes of Health (US)
- Bowling Green State University (US)
- Venue
- Behavioral Neuroscience
- Published
- 2001-08
- Volume
- 115
- Issue
- 4
- Pages
- 940-944
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2094849700
- Cited by
- 258
- References
- 27
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 7 · 2023: 6 · 2022: 5 · 2021: 13 · 2020: 10 · 2019: 20 · 2018: 22 · 2017: 8 · 2016: 13 · 2015: 15 · 2014: 19 · 2013: 19 · 2012: 15
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Developmental Biology › Animal Vocal Communication and Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- nucleus accumbens, amphetamine, 50-kHz ultrasonic vocalizations, reward anticipation, locomotor activity, caudate-putamen, rats
- MeSH terms
- Amphetamine, Central Nervous System Stimulants, Animals, Appetitive Behavior, Male, Microinjections, Nucleus Accumbens, Random Allocation, Ultrasonics, Vocalization, Animal, Dopamine Agents, Rats, Sprague-Dawley, Rats
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