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Cited by 182Neurotransmitter Receptor Influence on BehaviorAnimal Vocal Communication and BehaviorNeuroscience and Neuropharmacology Research

Amphetamine-induced 50kHz calls from rat nucleus accumbens: A quantitative mapping study and acoustic analysis

Thompson, Briar, Leonard, Kevin C., Brudzynski, Stefan M.·2006·Behavioural Brain Research
DOI 10.1016/j.bbr.2005.10.012
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Abstract

Emission of 50 kHz ultrasonic calls in rats is known to be associated with appetitive behavioural situations and positive social interactions. The purpose of the study was to pharmacologically characterize amphetamine-induced 50 kHz calls and to perform quantitative mapping of this response in the nucleus accumbens. Injections of amphetamine into the nucleus accumbens induced species-typical 50 kHz calls in adult rats. The acoustic parameters of the calls were not affected by different amphetamine doses or combination of agents. The increase in the number of calls occurred predominantly from the accumbens shell and to a lesser degree from the core region. This effect was dose-dependent within the range of 1-20 microg of amphetamine and was reversed by pretreatment with D1 or D2 dopamine antagonists (SKF-83566 or raclopride) administered to the same brain site. However, another D2 dopamine receptor antagonist, haloperidol, which is known to increase the accumbens dopamine level, was ineffective in reversing the increase in call number at the dose studied. On the contrary, intraacumbens haloperidol, when injected alone, caused an increase in 50 kHz calls. It is concluded that the release of dopamine, predominantly in the accumbens shell region, is responsible for production of 50 kHz calls and the calls may indicate an appetitive state compatible with anticipation of reward and positive affect. Both D1 and D2 subtypes of dopamine receptors may be necessary to induce 50 kHz calls and signal the appetitive state.

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  • Microinjections of amphetamine into the medial shell, more readily than the core, elicit high frequency (around 50-Hz) ultrasonic vocalizations, which have been implicated in positive motivational states in rats.

    “Microinjections of amphetamine into the medial shell, more readily than the core, elicit high frequency (around 50-Hz) ultrasonic vocalizations (Burgdorf et al., 2001; Thompson et al., 2006), which have been implicated in positive motivational states in rats (Knutson et al., 2002).”

    From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Thompson et al., 2006

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Authors
Thompson, B., Leonard, K. C., & Brudzynski, S. M.
Affiliations
Brock University (CA)
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2006-03
Volume
168
Issue
1
Pages
64-73
ISSN
0166-4328 (ISSN-L)
DOI
10.1016/j.bbr.2005.10.012
OpenAlex
W2022554996
Cited by
182
References
57
Citations by year
2026: 8 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 13 · 2020: 5 · 2019: 13 · 2018: 21 · 2017: 6 · 2016: 8 · 2015: 17 · 2014: 11 · 2013: 15 · 2012: 6
FWCI
1.92
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Developmental Biology › Animal Vocal Communication and Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
amphetamine, nucleus accumbens, nucleus accumbens shell, dopamine release, dopamine D1 receptor, dopamine D2 receptor, haloperidol, raclopride, reward anticipation, positive affect, acoustic analysis
MeSH terms
Amphetamine, Central Nervous System Stimulants, Animals, Appetitive Behavior, Brain Mapping, Caudate Nucleus, Dose-Response Relationship, Drug, Haloperidol, Interpersonal Relations, Male, Microinjections, Nucleus Accumbens, Putamen, Stereotaxic Techniques, Vocalization, Animal, Rats, Wistar, Receptors, Dopamine D1, Dopamine Antagonists, Rats, Dopamine D2 Receptor Antagonists

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