Early-life maternal separation and social isolation produce an increase in impulsive action but not impulsive choice
Abstract
Early life environment, events, and context, such as mother-offspring relationship, can have profound effects on future behavior and physiology. We investigated the effects of long-term maternal and social separation, through artificial rearing, on adult impulsivity. Rats were maternally reared (MR) or artificially reared (AR) and half of the AR rats were provided with replacement somatosensory stimulation intended to simulate maternal licking. There are at least 2 forms of impulsivity and we compared rats on 1 test of impulsive action (differential reinforcement of low rates of responding-DRL-20s) and 2 tests of impulsive choice (delay discounting and fixed consecutive number schedule-FCN). We found that AR rats are more action impulsive; however, this effect can be reduced by maternal licking-like stimulation. In contrast, AR rats did not display an increase in impulsive choice. Overall, these experiments show that early life maternal and social separation have different effects on the 2 forms of impulsivity.
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Rodents reared in isolation displayed more inattentive and impulsive behaviors.
“displayed more inattentive and impulsive behaviors (Lovic et al., 2011; Ouchi et al., 2013),”
From The maternal brain and its plasticity in humans (2016) · cites this paper as Lovic et al., 2011
Early exposure to low quality maternal care may alter the development of dopaminergic pathways associated with reward-related behaviors and response to drugs.
“Early exposure to low quality maternal care may also alter the development of dopaminergic pathways associated with reward-related behaviors, and response to drugs.”
From The maternal brain and its plasticity in humans (2016) · cites this paper as Lovic et al., 2011
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Dudley, J. (2013) · UCL Discovery (University College London)
- Authors
- Lovic, V., Keen, D., Fletcher, P. J., & Fleming, A. S.
- Affiliations
- University of Toronto (CA)
- Centre for Addiction and Mental Health (CA)
- Venue
- Behavioral Neuroscience
- Published
- 2011
- Volume
- 125
- Issue
- 4
- Pages
- 481-491
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2037084677
- Cited by
- 72
- References
- 52
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 2 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 2 · 2017: 7 · 2016: 3 · 2015: 10 · 2014: 8 · 2013: 6 · 2012: 2
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Sciences and Engineering Research Council
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- maternal separation, social isolation, artificial rearing, impulsivity, impulsive action, impulsive choice, delay discounting, differential reinforcement of low rates, maternal licking, somatosensory stimulation, early life environment, rats
- MeSH terms
- Analysis of Variance, Animals, Animals, Newborn, Choice Behavior, Conditioning, Operant, Female, Food Deprivation, Impulsive Behavior, Male, Maternal Deprivation, Reinforcement, Psychology, Reinforcement Schedule, Social Isolation, Time Factors, Rats, Sprague-Dawley, Rats
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