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Cited by 17Child and Adolescent Psychosocial and Emotional DevelopmentMental Health Research TopicsPsychology and Mental Health

Intergenerational continuity in parents’ and adolescents’ externalizing problems: The role of life events and their interaction with GABRA2.

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Salvatore, Jessica E., Meyers, Jacquelyn L., Yan, Jia, Aliev, Fazil, Lansford, Jennifer E., Pettit, Gregory S., Bates, John E., Dodge, Kenneth A. +4 more·2015·Journal of Abnormal Psychology
DOI 10.1037/abn0000066PMC PMC4573794
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Abstract

We examine whether parental externalizing behavior has an indirect effect on adolescent externalizing behavior via elevations in life events, and whether this indirect effect is further qualified by an interaction between life events and adolescents' GABRA2 genotype (rs279871). We use data from 2 samples: the Child Development Project (CDP; n = 324) and FinnTwin12 (n = 802). In CDP, repeated measures of life events, mother-reported adolescent externalizing, and teacher-reported adolescent externalizing were used. In FinnTwin12, life events and externalizing were assessed at age 14. Parental externalizing was indexed by measures of antisocial behavior and alcohol problems or alcohol dependence symptoms in both samples. In CDP, parental externalizing was associated with more life events, and the association between life events and subsequent adolescent externalizing varied as a function of GABRA2 genotype (p ≤ .05). The association between life events and subsequent adolescent externalizing was stronger for adolescents with 0 copies of the G minor allele compared to those with 1 or 2 copies of the minor allele. Parallel moderation trends were observed in FinnTwin12 (p ≤ .11). The discussion focuses on how the strength of intergenerational pathways for externalizing psychopathology may differ as a function of adolescent-level individual differences.

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  • In FinnTwin 12, there were no significant parallel moderation trends (p = <0.11).

    “FinnTwin 12 (b): NS parallel moderation trends (p = <0.11)”

    From Genetics of child aggression, a systematic review (2024) · cites this paper as Salvatore [161]

  • In the Child Development Project (CDP) sample, there was a gene-environment interaction: no G allele plus life events led to increased externalizing (p = <0.05).

    “CDP (a): GxE: no G allele + life events -> increased externalizing (p = <0.05)”

    From Genetics of child aggression, a systematic review (2024) · cites this paper as Salvatore [161]

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Cited by

Sorted by citations

Authors
Salvatore, J. E., Meyers, J. L., Yan, J., Aliev, F., Lansford, J. E., Pettit, G. S., Bates, J. E., Dodge, K. A., Rose, R. J., Pulkkinen, L., Kaprio, J., & Dick, D. M.
Affiliations
  • Virginia Commonwealth University (US)
  • Duke University (US)
  • Auburn University (US)
  • Indiana University Bloomington (US)
  • University of Jyväskylä (FI)
  • University of Helsinki (FI)
ORCID
Venue
Journal of Abnormal Psychology
Publisher
American Psychological Association (APA)
Published
2015-08
Volume
124
Issue
3
Pages
709-728
ISSN
  • 0021-843X (ISSN-L)
  • 1939-1846
DOI
10.1037/abn0000066
PMC
PMC4573794
OpenAlex
W2113688546
Cited by
17
References
5
Citations by year
2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2020: 2 · 2019: 5 · 2017: 3 · 2016: 2
FWCI
2.07
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Abnormal Psychology (publishedVersion, other-oa)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Jyväskylä University Digital Archive (University of Jyväskylä) (submittedVersion)
  • STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
Funders
  • National Institute of Mental Health (MH42498, MH56961, MH57024, MH057024-07S1, and MH57095)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD30572)
  • National Institute on Drug Abuse (DA016903)
  • National Institute on Alcohol Abuse and Alcoholism (AA12502, AA00145, and AA09203, AA15416 and K02AA018755)
  • Academy of Finland (100499, 205585, 141054, 118555, 265240, 263278, and 264146, 213506 and 129680)
  • Sponsor name not included (T32MH20030-14 and F32AA022269)
  • TUBITAK (114C117)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
  • Social Sciences › Psychology › Clinical Psychology › Psychology and Mental Health
Keywords
intergenerational transmission, externalizing problems, adolescent externalizing behavior, life events, gene-environment interaction, alcohol problems, alcoholism, individual differences
MeSH terms
Adolescent, Aggression, Alcoholism, Alleles, Antisocial Personality Disorder, Child, Female, Genotype, Humans, Life Change Events, Male, Parent-Child Relations, Parents, Receptors, GABA-A, Twins, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Gene-Environment Interaction

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