High resolution examination of the role of sleep disturbance in predicting functioning and psychotic symptoms in schizophrenia: A novel experience sampling study
Open accessAbstract
Sleep disturbance is common in schizophrenia, but its role in predicting functioning and psychotic symptoms has yet to be rigorously examined. The purpose of this study was to conduct a prospective, high-resolution examination of the relationship between nightly sleep and next-day functioning and psychotic symptoms in people with a diagnosis of schizophrenia. Experience sampling methodology was integrated with actigraphy and sleep diaries across 7 days in 22 patients with a diagnosis of schizophrenia. Momentary assessments of mood, psychotic symptoms, and functioning were gathered at 5 points each day following pseudorandom schedules. Multilevel modeling was performed to evaluate the links between variables. Objective and subjective sleep disturbance predicted reduced next-day functioning, which remained significant after controlling for psychotic symptom severity. Increased sleep fragmentation and reduced subjective and objective sleep efficiency predicted greater next-day auditory hallucinations, whereas increased objective sleep fragmentation and reduced subjective sleep quality predicted greater paranoia and delusions of control. Negative affect on awakening mediated a proportion of these relationships (range: 17.9-57.3%). For the first time, we show that sleep disturbance is a predictor of next-day impaired functioning and psychotic symptom severity in people with a diagnosis of schizophrenia. Therefore, interventions targeting sleep may have the potential to directly and indirectly enhance functional and symptomatic recovery in those experiencing psychosis. (PsycINFO Database Record
AI snapshot
Written from the paper’s full text.
TL;DR
In 22 patients with schizophrenia-spectrum diagnoses and insomnia, nightly objective and subjective sleep disturbance predicted worse next-day functioning and more severe psychotic symptoms, with morning negative affect mediating part of these relationships. Sleep continuity and quality, rather than duration, were particularly implicated in next-day auditory hallucinations, paranoia, and delusions of control.
Key findings
- Both objective and subjective sleep disturbance predicted reduced next-day functioning after controlling for baseline PANSS score; greater objective/subjective sleep efficiency, subjective sleep quality, and objective/subjective total sleep time predicted greater next-day functioning, while greater objective sleep fragmentation predicted decreased next-day functioning.
- Increased objective and subjective sleep efficiency predicted reduced auditory hallucinations; increased objective sleep fragmentation predicted increased auditory hallucinations and paranoia; increased subjective sleep quality predicted reduced auditory hallucinations, paranoia, and delusions of control.
- Morning negative affect mediated a proportion of the total effects of sleep parameters on next-day functioning and psychotic symptoms (abstract range: 17.9%–57.3%; results: functioning 19.5%–57.3%, psychotic symptoms 17.9%–50.9%). Direct effects of objective sleep fragmentation and subjective sleep quality on paranoia remained significant, whereas direct effects between sleep parameters and both auditory hallucinations and delusions of control failed to reach significance after including negative affect.
Methods
- Prospective, high-resolution experience sampling study integrated with actigraphy and sleep diaries across seven days in 22 eligible patients with a schizophrenia-spectrum diagnosis and Insomnia Severity Index score ≥10; two participants were excluded for circadian rhythm disturbances. ESM prompts occurred five times per day on pseudo-random schedules; actigraphy was recorded over six days and nights, and sleep diaries were completed each morning.
- Baseline measures included PANSS, PSYRATS, Calgary Depression Scale, DAST-10, AUDIT-10, and PSP. Daily sleep variables were sleep efficiency, sleep fragmentation, total sleep time, and subjective sleep quality; ESM items assessed negative/positive affect, psychotic symptoms, and functioning.
- Multilevel modelling used random-effects regression with maximum likelihood estimation, participant as a random effect, and non-parametric bootstrapping with 200 replications for skewed day-level variables. Mediation by morning negative affect was tested using the differences-in-coefficients approach.
Limitations
- Paper-stated limitations: linear associations preclude causal inferences; psychotic symptom items were fairly simplistic and may not capture multidimensional hallucinations and delusions; the chronic, antipsychotic-medicated sample may have confounded relationships; actigraphy and sleep diaries could not assess sleep architecture or oscillations; two individuals were excluded for circadian rhythm disturbances; substance use was low but not examined.
- Paper-stated: some non-significant findings had p-values less than 0.1, suggesting the analyses might have been underpowered. Evident from the text: the sample was small (n = 22), chronic in presentation (mean duration since diagnosis 12 years, S.D. = 6.2), and selected for insomnia severity, limiting generalizability.
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Integrity signals
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Cites
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Claims the paper makes
0 of 36 cited sources checked · 0 supported · 0 flagged
- Findingown data
Negative affect on awakening mediated a proportion of the relationships between sleep and next-day functioning and psychotic symptoms, with mediation proportions ranging from 17.9% to 57.3%.
“Negative affect on awakening mediated a proportion of these relationships (range: 17.9% -57.3%).”
Quote in the paperSubstantial claim - Findingown data
Reduced subjective sleep quality predicted greater delusions of control.
“increased objective sleep fragmentation and reduced subjective sleep quality predicted greater paranoia and delusions of control.”
Quote in the paperSubstantial claim - Findingown data
Increased objective sleep fragmentation predicted greater delusions of control.
“increased objective sleep fragmentation and reduced subjective sleep quality predicted greater paranoia and delusions of control.”
Quote in the paperSubstantial claim - Findingown data
Increased sleep fragmentation predicted greater next-day auditory hallucinations.
“Increased sleep fragmentation and reduced subjective and objective sleep efficiency predicted greater next-day auditory hallucinations”
Quote in the paperSubstantial claim - Findingown data
Increased objective sleep fragmentation predicted greater paranoia.
“increased objective sleep fragmentation and reduced subjective sleep quality predicted greater paranoia and delusions of control.”
Quote in the paperSubstantial claim
- Findingown data
Reduced subjective sleep efficiency predicted greater next-day auditory hallucinations.
“Increased sleep fragmentation and reduced subjective and objective sleep efficiency predicted greater next-day auditory hallucinations”
Quote in the paperSubstantial claim - Findingown data
Reduced subjective sleep quality predicted greater paranoia.
“increased objective sleep fragmentation and reduced subjective sleep quality predicted greater paranoia and delusions of control.”
Quote in the paperSubstantial claim - Findingown data
Reduced objective sleep efficiency predicted greater next-day auditory hallucinations.
“Increased sleep fragmentation and reduced subjective and objective sleep efficiency predicted greater next-day auditory hallucinations”
Quote in the paperSubstantial claim - Findingown data
Increased objective SF predicted increased paranoia after adjusting for baseline PANSS score.
“Table four shows that after adjusting for baseline PANSS score, increased objective and subjective SE significantly predicted reduced auditory hallucinations; increased objective SF predicted increased auditory hallucinations and paranoia, while increased subjective SQ predicted reduced auditory hallucinations, paranoia and delusions of control.”
Quote in the paperSubstantial claim - Findingown data
Greater objective SE predicted greater next-day functioning after adjusting for baseline PANSS scores.
“Table two shows that greater objective and subjective SE, subjective SQ and both objective and subjective TST predicted greater next-day functioning scores, while greater objective SF predicted decreased next-day functioning, after adjusting for baseline PANSS scores.”
Quote in the paperSubstantial claim - Findingown data
Morning NA mediated a varying proportion (17.9%-50.9%) of the total effect of sleep parameters on next-day psychotic symptoms.
“When comparing the coefficients between the total (analysis without NA) and direct effects (analysis including NA), NA mediated a varying proportion of the total effect of sleep parameters on next-day psychotic symptoms (range: 17.9% -50.9%).”
Quote in the paperSubstantial claim - Findingown data
Increased subjective SE predicted reduced auditory hallucinations after adjusting for baseline PANSS score.
“Table four shows that after adjusting for baseline PANSS score, increased objective and subjective SE significantly predicted reduced auditory hallucinations; increased objective SF predicted increased auditory hallucinations and paranoia, while increased subjective SQ predicted reduced auditory hallucinations, paranoia and delusions of control.”
Quote in the paperSubstantial claim - Findingown data
Morning NA mediated a varying proportion (19.5%-57.3%) of the total effects of sleep parameters on next-day functioning.
“When comparing the coefficients between the total (analysis without NA) and direct effects (analysis including NA), NA mediated a varying proportion of the total effects of sleep parameters on next-day functioning (range: 19.5% -57.3%).”
Quote in the paperSubstantial claim - Findingown data
Increased subjective SQ predicted reduced auditory hallucinations after adjusting for baseline PANSS score.
“Table four shows that after adjusting for baseline PANSS score, increased objective and subjective SE significantly predicted reduced auditory hallucinations; increased objective SF predicted increased auditory hallucinations and paranoia, while increased subjective SQ predicted reduced auditory hallucinations, paranoia and delusions of control.”
Quote in the paperSubstantial claim - Findingown data
Direct effect of objective TST on next-day functioning remained significant after including morning NA.
“Although direct effects of objective and subjective sleep continuity (SE, SF) and quantity (TST) on next-day functioning remained significant, the direct effect of subjective SQ on functioning was not significant (Table 3).”
Quote in the paperSubstantial claim - Findingown data
All sleep parameters significantly predicted morning NA upon awakening.
“All sleep parameters significantly predicted NA upon wakening.”
- Also stated in: § Does morning NA mediate the relationship between objective / subjective sleep parameters and next-day psychotic symptoms? · plain
“All sleep parameters significantly predicted NA upon wakening.”
Quote in the paperSubstantial claim - Also stated in: § Does morning NA mediate the relationship between objective / subjective sleep parameters and next-day psychotic symptoms? · plain
- Findingown data
Direct effect of subjective SQ on paranoia remained significant after including morning NA.
“Whereas direct effects of objective SF and subjective SQ on paranoia remained significant, direct effects between sleep parameters and both auditory hallucinations and delusions of control failed to reach significance (Table 5).”
Quote in the paperSubstantial claim - Findingown data
Impairments in all sleep parameters reliably predicted worse next-day functioning after controlling for baseline symptom severity (total PANSS score).
“Specifically, impairments in all sleep parameters reliably predicted worse functioning after controlling for baseline symptom severity (total PANSS score).”
Quote in the paperSubstantial claim - Findingown data
Greater objective TST predicted greater next-day functioning after adjusting for baseline PANSS scores.
“Table two shows that greater objective and subjective SE, subjective SQ and both objective and subjective TST predicted greater next-day functioning scores, while greater objective SF predicted decreased next-day functioning, after adjusting for baseline PANSS scores.”
Quote in the paperSubstantial claim - Findingown data
Greater subjective SQ predicted greater next-day functioning after adjusting for baseline PANSS scores.
“Table two shows that greater objective and subjective SE, subjective SQ and both objective and subjective TST predicted greater next-day functioning scores, while greater objective SF predicted decreased next-day functioning, after adjusting for baseline PANSS scores.”
Quote in the paperSubstantial claim - Findingown data
Greater subjective TST predicted greater next-day functioning after adjusting for baseline PANSS scores.
“Table two shows that greater objective and subjective SE, subjective SQ and both objective and subjective TST predicted greater next-day functioning scores, while greater objective SF predicted decreased next-day functioning, after adjusting for baseline PANSS scores.”
Quote in the paperSubstantial claim - Findingown data
Increased objective SF predicted increased auditory hallucinations after adjusting for baseline PANSS score.
“Table four shows that after adjusting for baseline PANSS score, increased objective and subjective SE significantly predicted reduced auditory hallucinations; increased objective SF predicted increased auditory hallucinations and paranoia, while increased subjective SQ predicted reduced auditory hallucinations, paranoia and delusions of control.”
Quote in the paperSubstantial claim - Findingown data
Direct effects between sleep parameters and auditory hallucinations failed to reach significance after including morning NA.
“Whereas direct effects of objective SF and subjective SQ on paranoia remained significant, direct effects between sleep parameters and both auditory hallucinations and delusions of control failed to reach significance (Table 5).”
Quote in the paperSubstantial claim - Findingown data
Increased objective SE predicted reduced auditory hallucinations after adjusting for baseline PANSS score.
“Table four shows that after adjusting for baseline PANSS score, increased objective and subjective SE significantly predicted reduced auditory hallucinations; increased objective SF predicted increased auditory hallucinations and paranoia, while increased subjective SQ predicted reduced auditory hallucinations, paranoia and delusions of control.”
Quote in the paperSubstantial claim - Findingown data
Direct effect of subjective SQ on next-day functioning was not significant after including morning NA.
“Although direct effects of objective and subjective sleep continuity (SE, SF) and quantity (TST) on next-day functioning remained significant, the direct effect of subjective SQ on functioning was not significant (Table 3).”
Quote in the paperSubstantial claim - Findingown data
Greater subjective SE predicted greater next-day functioning after adjusting for baseline PANSS scores.
“Table two shows that greater objective and subjective SE, subjective SQ and both objective and subjective TST predicted greater next-day functioning scores, while greater objective SF predicted decreased next-day functioning, after adjusting for baseline PANSS scores.”
Quote in the paperSubstantial claim - Findingown data
Greater objective SF predicted decreased next-day functioning after adjusting for baseline PANSS scores.
“Table two shows that greater objective and subjective SE, subjective SQ and both objective and subjective TST predicted greater next-day functioning scores, while greater objective SF predicted decreased next-day functioning, after adjusting for baseline PANSS scores.”
Quote in the paperSubstantial claim - Findingown data
Increased subjective SQ predicted reduced delusions of control after adjusting for baseline PANSS score.
“Table four shows that after adjusting for baseline PANSS score, increased objective and subjective SE significantly predicted reduced auditory hallucinations; increased objective SF predicted increased auditory hallucinations and paranoia, while increased subjective SQ predicted reduced auditory hallucinations, paranoia and delusions of control.”
Quote in the paperSubstantial claim - Findingown data
Direct effects between sleep parameters and delusions of control failed to reach significance after including morning NA.
“Whereas direct effects of objective SF and subjective SQ on paranoia remained significant, direct effects between sleep parameters and both auditory hallucinations and delusions of control failed to reach significance (Table 5).”
Quote in the paperSubstantial claim - Findingown data
Direct effect of objective SE on next-day functioning remained significant after including morning NA.
“Although direct effects of objective and subjective sleep continuity (SE, SF) and quantity (TST) on next-day functioning remained significant, the direct effect of subjective SQ on functioning was not significant (Table 3).”
Quote in the paperSubstantial claim - Findingown data
Increased subjective SQ predicted reduced paranoia after adjusting for baseline PANSS score.
“Table four shows that after adjusting for baseline PANSS score, increased objective and subjective SE significantly predicted reduced auditory hallucinations; increased objective SF predicted increased auditory hallucinations and paranoia, while increased subjective SQ predicted reduced auditory hallucinations, paranoia and delusions of control.”
Quote in the paperSubstantial claim - Findingown data
Direct effect of objective SF on next-day functioning remained significant after including morning NA.
“Although direct effects of objective and subjective sleep continuity (SE, SF) and quantity (TST) on next-day functioning remained significant, the direct effect of subjective SQ on functioning was not significant (Table 3).”
Quote in the paperSubstantial claim - Findingown data
Only parameters of sleep continuity (SE, SF) and quality (SQ) significantly predicted next-day psychotic symptoms.
“However, only parameters of sleep continuity (SE, SF) and quality (SQ) significantly predicted next-day symptoms.”
Quote in the paperSubstantial claim - Findingown data
Direct effect of subjective SF on next-day functioning remained significant after including morning NA.
“Although direct effects of objective and subjective sleep continuity (SE, SF) and quantity (TST) on next-day functioning remained significant, the direct effect of subjective SQ on functioning was not significant (Table 3).”
Quote in the paperSubstantial claim - Findingown data
Direct effect of objective SF on paranoia remained significant after including morning NA.
“Whereas direct effects of objective SF and subjective SQ on paranoia remained significant, direct effects between sleep parameters and both auditory hallucinations and delusions of control failed to reach significance (Table 5).”
Quote in the paperSubstantial claim - Findingown data
Direct effect of subjective TST on next-day functioning remained significant after including morning NA.
“Although direct effects of objective and subjective sleep continuity (SE, SF) and quantity (TST) on next-day functioning remained significant, the direct effect of subjective SQ on functioning was not significant (Table 3).”
Quote in the paperSubstantial claim - Findingown data
Direct effect of subjective SE on next-day functioning remained significant after including morning NA.
“Although direct effects of objective and subjective sleep continuity (SE, SF) and quantity (TST) on next-day functioning remained significant, the direct effect of subjective SQ on functioning was not significant (Table 3).”
Quote in the paperSubstantial claim - Findingown data
Visual hallucinations and grandiosity were not sufficiently endorsed across the study period (less than 20% of entry points rated greater than 1).
“Analysis of frequencies suggested that visual hallucinations and grandiosity were not sufficiently endorsed across the study period [i.e. less than 20% of entry points were rated greater than 1 (”
Quote in the paperSubstantial claim - Findingown data
Objective and subjective indices of sleep continuity, quality and duration significantly predicted next-day functioning.
“In line with our hypotheses, objective and subjective indices of sleep continuity, quality and duration significantly predicted next-day functioning.”
Quote in the paperSubstantial claim - Premisecitation
Increased negative affect has been reliably demonstrated after experimental sleep restriction and fragmentation in non-clinical studies.
“Moreover, increased negative affect has been reliably demonstrated after experimental sleep restriction and fragmentation in non-clinical studies (Finan, Quartana & Smith, 2015), representing a potential pathway through which both impaired functioning and symptom severity may be potentiated by sleep disturbance in vulnerable populations.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Finan, Quartana & Smith, 2015
Not checked in the free run.
- Premisecitation
There is evidence for a positive relationship between insomnia and severity of delusions.
“For instance, there is evidence to suggest a positive relationship between insomnia and severity of both delusions (Myers, Startup, & Freeman, 2011) and hallucinations (Reich, Weiss, Coble, McPartland, & Kupfer, 1975).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Myers, Startup, & Freeman, 2011
Not checked in the free run.
- Premisecitation
Cognitive models of psychosis identify negative affect as an important contributory and maintaining factor in both paranoia and auditory hallucinations.
“cognitive models of psychosis identify negative affect as an important contributory and maintaining factor in both paranoia and auditory hallucinations (Waters et al., 2012;Freeman & Garety, 2003).”
Quote in the paperSubstantial claim0 of 2 sources checked- cites Waters et al., 2012
Not checked in the free run.
- cites Freeman & Garety, 2003
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- Interpretationown data
Sleep disturbance is a predictor of next-day impaired functioning and psychotic symptom severity in people with a diagnosis of schizophrenia.
“For the first time, we show that sleep disturbance is a predictor of next-day impaired functioning and psychotic symptom severity in people with a diagnosis of schizophrenia.”
Quote in the paperSubstantial claim- Rests on an assumption: The sample of 22 patients with chronic schizophrenia and insomnia is representative of people with a diagnosis of schizophrenia.
- Premisecitation
There is evidence for a positive relationship between insomnia and severity of hallucinations.
“For instance, there is evidence to suggest a positive relationship between insomnia and severity of both delusions (Myers, Startup, & Freeman, 2011) and hallucinations (Reich, Weiss, Coble, McPartland, & Kupfer, 1975).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Reich, Weiss, Coble, McPartland, & Kupfer, 1975
Not checked in the free run.
- Premisecitation
Sleep disturbance is associated with increased psychosis severity when measured subjectively or objectively.
“Studies have also demonstrated that sleep disturbance is associated with increased psychosis severity, when measured subjectively (Xiang et al., 2009) or objectively (Waters et al., 2011).”
Quote in the paperSubstantial claim0 of 2 sources checked- cites Xiang et al., 2009
Not checked in the free run.
- cites Waters et al., 2011
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- Premisecitation
A recent systematic review highlighted a dearth of well-controlled, longitudinal studies examining sleep parameters and individual psychotic symptoms, especially in people with a diagnosis of schizophrenia.
“However, a recent systematic review of the relationship between sleep disturbance and psychosis highlighted a dearth of well-controlled, longitudinal studies examining sleep parameters and individual psychotic symptoms, especially in people with a diagnosis of schizophrenia (Reeve, Sheaves & Freeman, 2015).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Reeve, Sheaves & Freeman, 2015
Not checked in the free run.
- Premisecitation
The role of sleep disturbance in predicting functioning and psychotic symptoms in schizophrenia has yet to be rigorously examined.
“Sleep disturbance is common in schizophrenia but its role in predicting functioning and psychotic symptoms has yet to be rigorously examined.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Reeve, Sheaves & Freeman, 2015
Not checked in the free run.
- Interpretationown data
The effect of sleep parameters on paranoia may be less mediated by morning NA than the effect on auditory hallucinations and delusions of control.
“This suggests that in comparison to auditory hallucinations and delusions of control, the effect of sleep parameters on paranoia may be less mediated by NA.”
Quote in the paperSubstantial claim - Study design and conductnone given
The study included a functioning measure developed in collaboration with people with lived experience of psychosis.
“A key strength of this study was the inclusion of a functioning measure, developed in collaboration with people with lived experience of psychosis.”
Quote in the paperSubstantial claim - Interpretationown data
The study identifies sleep continuity as an important therapeutic target in the pathway to improved symptom management.
“4) our study identifies sleep continuity as an important therapeutic target in the pathway to improved symptom management.”
Quote in the paperSubstantial claim - Interpretationown data
The findings demonstrate that sleep is a significant predictor of functional and symptomatic outcomes.
“The findings demonstrate that sleep is a significant predictor of functional and symptomatic outcomes.”
Quote in the paperSubstantial claim - Interpretationreasoning
The integration of actigraphy with ESM measurement on a single device may account for the high adherence rates.
“3) it is the first study to integrate actigraphy with ESM measurement on a single device, which may account for our high adherence rates and potentially opens up a novel approach to further investigate sleep and psychosis”
Quote in the paperSubstantial claim - Interpretationcitation
These findings significantly enhance previous work, which has reported cross-sectional relationships between sleep disturbance and both reduced QoL and cognitive functioning.
“These findings significantly enhance previous work, which has reported cross-sectional relationships between sleep disturbance and both reduced QoL (Ritnser et al., 2004;Hofstetter et al., 2005) and cognitive functioning (Forest et al., 2007;Keshavan et al., 2004).”
Quote in the paperSubstantial claim0 of 3 sources checked- cites Ritnser et al., 2004
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- cites Hofstetter et al., 2005
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- cites Forest et al., 2007
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- Study design and conductreasoning
The use of actigraphy and sleep diaries did not permit investigation of the relationship between sleep architectural parameters or sleep oscillations and functioning and symptoms.
“Fourth, the use of actigraphy and sleep diaries did not permit investigation of the relationship between sleep architectural parameters or sleep oscillations (e.g.spindles, slow waves) and functioning and symptoms.”
Quote in the paperNot a substantial claim - Interpretationown data
The analyses might have been underpowered, as suggested by the uniformity of results and some non-significant findings with p-values less than 0.1.
“The uniformity of the results was striking as all parameters predicted functioning and symptoms in the expected direction and some non-significant findings had p-values less than 0.1, suggesting the analyses might have been underpowered as opposed to there being no effect.”
Quote in the paperNot a substantial claim - Interpretationown data
Sleep discontinuity and perceptions of sleep quality are more important than sleep duration in predicting next-day psychotic symptoms.
“These results suggest that sleep discontinuity and perceptions of sleep quality are more important than sleep duration, in the prediction of next-day symptoms.”
Quote in the paperSubstantial claim - Interpretationcitation
The current findings converge with previous studies that have reported significant relationships between sleep disturbance and severity of psychotic symptoms, hallucinations, and paranoia.
“The current findings also converge with previous studies that have reported significant relationships between sleep disturbance and severity of psychotic symptoms (Waters et al., 2011), hallucinations (Reich et al., 1975) and paranoia (Myers et al., 2011).”
Quote in the paperNot a substantial claim0 of 3 sources checked- cites Waters et al., 2011
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- cites Reich et al., 1975
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- cites Myers et al., 2011
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- Study design and conductown data
The psychosis items did not demonstrate high levels of internal consistency (α = .498 and α = .677, respectively).
“These were chosen to provide measures of hallucinations (auditory, visual) and delusions (persecutory, grandiose, control); however, these scales did not demonstrate high levels of internal consistency (α = .498and α = .677,respectively).”
Quote in the paperSubstantial claim - Interpretationown data
Disturbances in sleep continuity and quality, rather than duration, are implicated in auditory hallucinations and delusions.
“In particular, disturbances in sleep continuity and quality, rather than duration are implicated in auditory hallucinations and delusions.”
Quote in the paperSubstantial claim
- May combine two claims. 18
- Classified as probably not a substantial claim. 26
May combine two claims.
Findingown dataBoth objective and subjective sleep disturbance predicted reduced next-day functioning, and this remained significant after controlling for psychotic symptom severity.
“Both objective and subjective sleep disturbance predicted reduced next-day functioning, which remained significant after controlling for psychotic symptom severity.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataMorning NA mediated a proportion of the total effect of all sleep parameters on next-day functioning; direct effects remained significant for all sleep parameters except subjective SQ.
“For all sleep parameters, morning NA mediated a proportion of the total effect on next-day functioning; however, direct effects remained significant for all but one sleep parameter (subjective SQ).”
Quote in the paperSubstantial claimClassified as probably not a substantial claim.
PremisecitationPreliminary studies find evidence for partial mediation of the link between insomnia severity and paranoia via negative affect.
“preliminary studies find evidence for partial mediation of the link between insomnia severity and paranoia via negative affect (Freeman, Pugh, Vorontsova & Southgate, 2009;Myers et al., 2011)”
Quote in the paperSubstantial claim0 of 2 sources checked- cites Freeman, Pugh, Vorontsova & Southgate, 2009
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- cites Myers et al., 2011
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Probably not a substantial claim: may not pass S2 (checkable).
InterpretationreasoningInterventions targeting sleep may have the potential to enhance functional and symptomatic recovery in those experiencing psychosis, both directly and indirectly.
“Interventions targeting sleep may therefore have the potential to enhance functional and symptomatic recovery in those experiencing psychosis, both directly and indirectly.”
Quote in the paperNot a substantial claim- Rests on an assumption: The sample of 22 patients with chronic schizophrenia and insomnia is representative of people with a diagnosis of schizophrenia.
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationSleep disturbance contributes to impaired performance on tasks of sustained attention, executive functioning, and IQ.
“Neuropsychological findings also demonstrate that sleep disturbance contributes to impaired performance on tasks of sustained attention (Forest et al., 2007), executive functioning (Keshavan, Cashmere, Miewald, & Yeragani, 2004) and IQ (Manoach et al., 2014).”
Quote in the paperNot a substantial claim0 of 3 sources checked- cites Forest et al., 2007
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- cites Keshavan, Cashmere, Miewald, & Yeragani, 2004
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- cites Manoach et al., 2014
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Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationThe PANSS total and subscales have high reliability and validity.
“The PANSS can be subdivided into positive, negative and general psychopathology scores and both the total and its subscales have high reliability and validity (Kay, Opler & Lindenmayer, 1988).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Kay, Opler & Lindenmayer, 1988
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PremisecitationThe PSYRATS has been widely validated and has high reliability.
“The PSYRATS has been widely validated and has high reliability (Haddock et al., 1999).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Haddock et al., 1999
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Classified as probably not a substantial claim.
PremisecitationSleep disturbance is associated with impaired quality of life and coping in people experiencing psychosis.
“Indeed, research has shown that sleep disturbance is associated with impaired quality of life (QoL) and coping in people experiencing psychosis (Ritsner, Kurs, Ponizovsky, & Hadjez, 2004;Hofstetter, Lysaker, & Mayeda, 2005).”
Quote in the paperSubstantial claim0 of 2 sources checked- cites Ritsner, Kurs, Ponizovsky, & Hadjez, 2004
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- cites Hofstetter, Lysaker, & Mayeda, 2005
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PremisecitationSleep disturbance is an important transdiagnostic factor implicated in the development and maintenance of a range of psychiatric disorders.
“Sleep disturbance is considered an important transdiagnostic factor, implicated in the development and maintenance of a range of psychiatric disorders (Harvey, 2008).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Harvey, 2008
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PremisecitationThe ISI cut-off score of 10 is optimal for identifying insomnia with the highest sensitivity and specificity.
“A cut-off score of 10 was used to determine eligibility, as this has been judged as optimal for identifying insomnia with the highest sensitivity and specificity (Morin, Belleville, Bélanger, & Ivers, 2011).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Morin, Belleville, Bélanger, & Ivers, 2011
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Probably not a substantial claim: may not pass S2 (checkable), S4 (based). May combine two claims.
Premisenone givenLow-resolution and cross-sectional studies are vulnerable to recall bias, are limited in depth and range of measurement, and are unable to examine relationships on a micro-scale.
“While this work has been informative, low-resolution and cross-sectional studies are vulnerable to recall bias, are limited in depth and range of measurement, and are unable to examine relationships on a micro-scale.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationThe DAST-10 reliability and validity has been demonstrated in samples experiencing psychosis.
“The reliability and validity of the DAST-10 has been demonstrated in samples experiencing psychosis (Cassidy, Schmitz, & Malla, 2008).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Cassidy, Schmitz, & Malla, 2008
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PremisecitationSleep disturbance is common in schizophrenia.
“Sleep disturbance is common in schizophrenia but its role in predicting functioning and psychotic symptoms has yet to be rigorously examined.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Cohrs, 2008
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Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationThe AUDIT is reliable and valid for use with people experiencing psychosis.
“The AUDIT is reliable and valid for use with people experiencing psychosis (Dawe, Seinen, & Kavanagh, 2000).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Dawe, Seinen, & Kavanagh, 2000
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Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationThe CDS has proven reliability and validity in populations with a diagnosis of schizophrenia.
“The CDS has proven reliability and validity in populations with a diagnosis of schizophrenia (Addington et al., 1993).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Addington et al., 1993
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May combine two claims.
Study design and conductnone givenThe sample included individuals who were chronic in presentation and in receipt of antipsychotic medication.
“Third, the sample included individuals who were chronic in presentation and in receipt of antipsychotic medication.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataOut of a possible 154 days of actigraph monitoring, 150 complete days were recorded (97.4%).
“Out of a possible 154 days of actigraph monitoring, 150 complete days were recorded (97.4%).”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationown dataBoth objective and subjective sleep parameters may be robust determinants of negative outcomes in people with a diagnosis of schizophrenia, as supported by their correspondence in relationships with next-day variables.
“Furthermore, the correspondence between objective and subjective sleep parameters in the relationship with next-day variables supports the proposition that both may be robust determinants of negative outcomes in people with a diagnosis of schizophrenia.”
Quote in the paperSubstantial claimMay combine two claims.
Study design and conductown dataOut of a possible 720 assessment points, a total of 557 entries were completed by participants within 15 minutes of each prompt, representing a 77.4% overall response rate.
“Out of a possible 720 assessment points, a total of 557 entries were completed by participants within 15 minutes of each prompt, representing a 77.4% overall response rate.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductcitationThe psychotic symptom items were fairly simplistic and may not capture the multidimensional experience of hallucinations and delusions.
“Second, although psychotic symptoms were assessed, these items were fairly simplistic and may not capture the multidimensional experience of hallucinations and delusions (Haddock et al., 1999).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Haddock et al., 1999
Not checked in the free run.
May combine two claims.
Study design and conductown dataThe NA and PA subscales had good internal consistency (α = .808 and α = .797, respectively).
“The NA (sad, anxious, irritable) and PA (happy, cheerful, relaxed, sleepy and energetic) subscales had good internal consistency (α = .808and α = .797,respectively).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationThe CSD has been credited as a gold-standard sleep diary.
“The CSD was developed by sleep experts and has been credited as a gold-standard sleep diary (Carney et al., 2012).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Carney et al., 2012
Not checked in the free run.
May combine two claims.
Study design and conductcitationAll twenty-two participants completed the full ESM schedule and completed more entries than the traditionally accepted one-third of assessment points.
“All twenty-two participants completed the full ESM schedule and completed more entries than the traditionally accepted one-third of assessment points (Palmier-Claus et al., 2011).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Palmier-Claus et al., 2011
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataCompletion of sleep diaries was high, as 147 nights out of a possible 154 nights of sleep were subjectively estimated (95.5%).
“Completion of sleep diaries was also high, as 147 nights out of a possible 154 nights of sleep were subjectively estimated (95.5%).”
Quote in the paperNot a substantial claimMay combine two claims.
Study design and conductreasoningThe study relied on the computation of linear associations between variables, so no causal inferences can be made regarding any relationships.
“First, the study relied on the computation of linear associations between variables and as such, no causal inferences can be made regarding any relationships.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
InterpretationreasoningThe inclusion of the functioning measure enabled the examination of how sleep impacts functioning as relevant to those with a diagnosis of schizophrenia.
“This enabled the examination of how sleep impacts functioning as relevant to those with a diagnosis of schizophrenia.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataThe total functioning scale had high internal consistency (α = .905).
“The total functioning scale was used in the analyses, which had high internal consistency (α = .905).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenTwo individuals were excluded from the study for exhibiting circadian rhythm disturbances.
“Fifth, two individuals were excluded from the study for exhibiting circadian rhythm disturbances.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductreasoningMedication may have confounded the observed relationships between sleep and next-day variables.
“Medication may have confounded the observed relationships between sleep and next-day variables.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationThe PSP is valid and reliable for use in samples with a diagnosis of schizophrenia.
“The PSP is valid and reliable for use in samples with a diagnosis of schizophrenia (Kawata & Revicki, 2008).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Kawata & Revicki, 2008
Not checked in the free run.
Classified as probably not a substantial claim.
InterpretationreasoningThe integration of actigraphy with ESM measurement on a single device potentially opens up a novel approach to further investigate sleep and psychosis.
“3) it is the first study to integrate actigraphy with ESM measurement on a single device, which may account for our high adherence rates and potentially opens up a novel approach to further investigate sleep and psychosis”
Quote in the paperSubstantial claimMay combine two claims.
Interpretationown dataSleep has a pronounced effect on next-day functioning independent of symptom severity, a proportion of which is mediated by morning NA.
“This indicates that sleep has a pronounced effect on nextday functioning independent of symptom severity, a proportion of which is mediated by morning NA.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim.
PremisecitationActigraphy has been validated for use within psychosis populations.
“Actigraphy provides a recording of continuous motor activity and has been validated for use within psychosis populations (Tahmasian, Khazaie, Golshani, & Avis, 2013).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Tahmasian, Khazaie, Golshani, & Avis, 2013
Not checked in the free run.
May combine two claims.
Interpretationown dataNightly sleep impairment is a significant predictor of poorer next-day functioning and greater symptom severity in individuals with a diagnosis of schizophrenia.
“We show that nightly sleep impairment is a significant predictor of poorer next-day functioning and greater symptom severity in individuals with a diagnosis of schizophrenia.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S2 (checkable).
InterpretationcitationTherapeutic interventions targeting sleep may have the potential to enhance both clinical and functional outcomes for people with schizophrenia.
“These findings suggest that therapeutic interventions targeting sleep may also have the potential to enhance both clinical and functional outcomes for people with schizophrenia (Freeman et al. 2015).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Freeman et al. 2015
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataLevels of alcohol and drug use were notably low in the sample.
“Lastly, although levels of alcohol and drug use were notably low in our sample, the impact of substance use on sleep parameters and next-day variables could be an interesting avenue for further research.”
Quote in the paperNot a substantial claim
The paper relies on this without support.
Comparatively little research has investigated the effects of sleep disturbance on functioning in people with a diagnosis of schizophrenia.
“Moreover, comparatively little research has investigated the effects of sleep disturbance on functioning in people with a diagnosis of schizophrenia.”
The paper relies on this without support.
Sleep is multi-dimensional and can fluctuate across nights, with corresponding next-day consequences.
“This is particularly important as sleep is multi-dimensional in nature and can fluctuate across nights, with corresponding next-day consequences.”
The paper relies on this without support.
Sleep disturbance, functioning and symptoms are all associated with negative affect.
“since 1) sleep disturbance, functioning and symptoms are all associated with negative affect”
The paper relies on this without support.
The sample of 22 patients with chronic schizophrenia and insomnia is representative of people with a diagnosis of schizophrenia.
“For the first time, we show that sleep disturbance is a predictor of next-day impaired functioning and psychotic symptom severity in people with a diagnosis of schizophrenia.”
The paper relies on this without support.
The seven-day ESM period is sufficient to capture stable relationships between nightly sleep and next-day functioning and symptoms.
“Experience sampling methodology was integrated with actigraphy and sleep diaries across seven days in twenty-two patients with a diagnosis of schizophrenia.”
The paper relies on this without support.
The study is the first well-controlled longitudinal evaluation of the relationship between objective and subjective sleep-wake patterns, functioning and psychotic symptoms in individuals with a diagnosis of schizophrenia.
“This study represents the first, well-controlled, longitudinal evaluation of the relationship between objective and subjective sleep-wake patterns, functioning and psychotic symptoms in individuals with a diagnosis of schizophrenia.”
The paper relies on this without support.
The study is the first to employ rigorous, high resolution measurement of sleep parameters and next-day variables over time within ESM.
“1) it is the first study to employ rigorous, high resolution measurement of sleep parameters and next-day variables over time, within the context of experience sampling methodology”
The paper relies on this without support.
The study is the first to explicitly test mediators of the night-to-day relationship between sleep, individual psychotic symptoms and functioning.
“2) it is the first study to explicitly test mediators of the night-to-day relationship between sleep, individual psychotic symptoms and functioning”
The paper relies on this without support.
The study is the first to integrate actigraphy with ESM measurement on a single device.
“3) it is the first study to integrate actigraphy with ESM measurement on a single device”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The effect of fragmented sleep and poorer self-reported sleep quality on paranoid experiences was mediated by negative affect on awakening.
“Furthermore, as in previous research, this effect was found to be mediated by negative affect on awakening.”
From A structural equation model of the relationship between insomnia, negative affect, and paranoid thinking (2017) · cites this paper as [24]
More fragmented sleep and poorer self-reported sleep quality were associated with more frequent paranoid experiences in a sample of 22 participants with schizophrenia.
“For example, Mulligan et al. [24] found that more fragmented sleep and poorer self-reported sleep quality were associated with more frequent paranoid experiences in a sample of 22 participants with a diagnosis of schizophrenia.”
From A structural equation model of the relationship between insomnia, negative affect, and paranoid thinking (2017) · cites this paper as [24]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Actigraphy duration differs between methods and results
MinorThe methods specify six days and nights of actigraphy, whereas the results report 154 possible monitoring days for 22 participants-seven days per participant.
“Actigraphy.Objective measurement of sleep-wake patterns was conducted using wrist actigraphy (CamNtech Patient Recorded Outcome-Diary, Cambridge) over a period of six days and nights, utilising an epoch of thirty seconds.”
“Out of a possible 154 days of actigraph monitoring, 150 complete days were recorded (97.4%).”
Wood citation year differs from the reference list
MinorThe in-text citation gives 2011, but the matching reference with the same four authors is dated 2013.
“This is despite service users emphasising the importance of functioning in their recovery (Wood, Price, Morrison, & Haddock, 2011).”
“48. Wood, L., Price, J., Morrison, A., & Haddock, G. (2013). Exploring service users perceptions of recovery from psychosis: A Q-methodological approach. Psychology & Psychotherapy: Theory, Research & Practice, 86(3), 245-261.”
Conflicting results for sleep fragmentation and delusions of control
MinorThe discussion says greater objective sleep fragmentation predicted increased delusions of control. The results summary lists fragmentation as a predictor of auditory hallucinations and paranoia, but lists only subjective sleep quality as a predictor of delusions of control.
“Furthermore, greater objective SF and reduced subjective SQ predicted increased paranoia and delusions of control.”
“Table four shows that after adjusting for baseline PANSS score, increased objective and subjective SE significantly predicted reduced auditory hallucinations; increased objective SF predicted increased auditory hallucinations and paranoia, while increased subjective SQ predicted reduced auditory hallucinations, paranoia and delusions of control.”
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Mobile Assessment Guide for Research in Schizophrenia and Severe Mental Disorders
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Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
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Cited by
Sorted by citations
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- Authors
- Mulligan, L. D., Haddock, G., Emsley, R., Neil, S. T., & Kyle, S. D.
- Affiliations
- University of Manchester (GB)
- National Health Service (GB)
- John Radcliffe Hospital (GB)
- Corresponding author
- Mulligan, Lee D.
- Venue
- Journal of Abnormal Psychology
- Published
- 2016-08
- Volume
- 125
- Issue
- 6
- Pages
- 788-797
- ISSN
- 0021-843X (ISSN-L)
- 1939-1846
- OpenAlex
- W2469538675
- Cited by
- 101
- References
- 51
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 9 · 2023: 15 · 2022: 9 · 2021: 13 · 2020: 12 · 2019: 9 · 2018: 12 · 2017: 11 · 2016: 2
- FWCI
- 10.09
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- Locations
- Journal of Abnormal Psychology (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion, other-oa)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- sleep disorders, schizophrenia, sleep fragmentation, sleep efficiency, sleep quality, auditory hallucinations, paranoia, delusions of control, functioning, psychotic symptoms, actigraphy, ecological momentary assessment
- MeSH terms
- Ecological Momentary Assessment, Adult, Female, Humans, Male, Middle Aged, Schizophrenia, Schizophrenic Psychology, Sleep Deprivation, Sleep Wake Disorders, Young Adult, Actigraphy
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