Extreme sensitivity of some intestinal crypt cells to X and γ irradiation

POTTEN, CHRISTOPHER S.·1977·Nature

DOI 10.1038/269518a0

Open this paper in CoChat — free account

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/269518a0

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The intestinal crypt, a prototype stem cell compartment
Clevers, H. (2013) · Cell · doi:10.1016/j.cell.2013.07.004 · Cited by 1,223
Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications
Sato, T., & Clevers, H. (2013) · Science · doi:10.1126/science.1234852 · Cited by 1,170
Reparative inflammation takes charge of tissue regeneration
Karin, M., & Clevers, H. (2016) · Nature · doi:10.1038/nature17039 · Cited by 767
Mend Your Fences
Martini, E., Krug, S. M., Siegmund, B., Neurath, M. F., & Becker, C. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.03.007 · Cited by 668
The intestinal stem cell
Barker, N., van de Wetering, M., & Clevers, H. (2008) · Genes & Development · doi:10.1101/gad.1674008 · Cited by 629
Lgr5 stem cells are indispensable for radiation-induced intestinal regeneration
Metcalfe, C., Kljavin, N. M., Ybarra, R., & de Sauvage, F. J. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2013.11.008 · Cited by 575
Stem cells: the intestinal stem cell as a paradigm
Bach, S. P., Renehan, A. G., & Potten, C. S. (2000) · Carcinogenesis · doi:10.1093/carcin/21.3.469 · Cited by 236
Self-citation
Radiation‐induced tissue damage and response
McBride, W. H., & Schaue, D. (2020) · The Journal of Pathology · doi:10.1002/path.5389 · Cited by 155
A matter of life and death: stem cell survival in tissue regeneration and tumour formation
Soteriou, D., & Fuchs, Y. (2018) · Nature Reviews Cancer · doi:10.1038/nrc.2017.122 · Cited by 87
Epithelial WNT ligands are essential drivers of intestinal stem cell activation
Zou, W. Y., Blutt, S. E., Zeng, X.-L., Chen, M.-S., Lo, Y.-H., Castillo-Azofeifa, D., Klein, O. D., Shroyer, N. F., Donowitz, M., & Estes, M. K. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.093 · Cited by 73
The Protective Effect of Fermented Milk Kefir on Radiation-induced Apoptosis in Colonic Crypt Cells of Rats.
MATSUU, M., SHICHIJO, K., OKAICHI, K., WEN, C. Y., FUKUDA, E., NAKASHIMA, M., NAKAYAMA, T., SHIRAHATA, S., TOKUMARU, S., & SEKINE, I. (2003) · Journal of Radiation Research · doi:10.1269/jrr.44.111 · Cited by 38
Epithelial cell kinetics in the descending colon of the rat
Rijke, R. P. C., Plaisier, H. M., & Langendoen, N. J. (1979) · Virchows Archiv B Cell Pathology · doi:10.1007/bf02889093 · Cited by 16

Authors: POTTEN, C. S.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1977-10
Volume: 269
Issue: 5628
Pages: 518-521
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/269518a0
OpenAlex: W2021218606
Cited by: 441
References: 0
FWCI: 4.21
Type: journal article
Language: en
Open access: closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review