The DOI matches its Crossref record; 21 of the 22 references it cites were found in a registry or an index.
Stress and glucocorticoids impair retrieval of long-term spatial memory
Abstract
Extensive evidence from animal and human studies indicates that stress and glucocorticoids influence cognitive function. Previous studies have focused exclusively on glucocorticoid effects on acquisition and long-term storage of newly acquired information. Here we report that stress and glucocorticoids also affect memory retrieval. We show that rats have impaired performance in a water-maze spatial task after being given footshock 30 min before retention testing but are not impaired when footshock is given 2 min or 4 h before testing. These time-dependent effects on retention performance correspond to the circulating corticosterone levels at the time of testing, which suggests that the retention impairment is directly related to increased adrenocortical function. In support of this idea, we find that suppression of corticosterone synthesis with metyrapone blocks the stress-induced retention impairment. In addition, systemic corticosterone administered to non-stressed rats 30 min before retention testing induces dose-dependent retention impairment. The impairing effects of stress and glucocorticoids on retention are not due to disruption of spatial navigation per se. Our results indicate that besides the well described effects of stress and glucocorticoids on acquisition and consolidation processes, glucocorticoids also affect memory retrieval mechanisms.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“and can impair hippocampus-specific memory processing in rats (de Quervain et al. [157]; Conrad et al. [158]; Roozendaal et al. [159]) and people (Kirschbaum et al. [160]; de Quervain et al. [161]; Wolf et al. [162]; Payne et al. [163]; Buss et al. [164]; Wolf et al. [165]; Elzinga et al. [76]; Kuhlmann et al. [166]; Kuhlmann et al. [167]; Payne et al. [168]; Buchanan”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as de Quervain et al. [157]
Citations
Cites
Developments of a water-maze procedure for studying spatial learning in the rat
Morris, R. (1984) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(84)90007-4 · Cited by 7,180
The acute effects of corticosteroids on cognition: integration of animal and human model studies
LUPIEN, S., & MCEWEN, B. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00004-0 · Cited by 1,024
Brain corticosteroid receptor balance and homeostatic control
de Kloet, E. R. (1991) · Frontiers in Neuroendocrinology · Cited by 842
Kirschbaum, C., Wolf, O. T., May, M., Wippich, W., & Hellhammer, D. H. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00118-x · Cited by 815
Repeated stress causes reversible impairments of spatial memory performance.
Luine, V., Villegas, M., Martinez, C., & McEwen, B. (1994) · Brain Research · doi:10.1016/0006-8993(94)91778-7 · Cited by 813
Conrad, C. D., Galea, L. A. M., Kuroda, Y., & McEwen, B. S. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.6.1321 · Cited by 805
Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning.
Oitzl, M. S., & de Kloet, E. R. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.1.62 · Cited by 649
Sandi, C., Loscertales, M., & Guaza, C. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01412.x · Cited by 447
Glucocorticoid-induced impairment in declarative memory performance in adult humans
Newcomer, J., Craft, S., Hershey, T., Askins, K., & Bardgett, M. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-04-02047.1994 · Cited by 441
LUPIEN, S. J., Gaudreau, S., Tchiteya, B. M., Maheu, F. S., Sharma, S., Nair, N. P. V., Hauger, R. L., McEwen, B. S., & Meaney, M. J. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.7.4075 · Cited by 394
Research works printed but not linked: 1
- Orchinik, M., Moore, F. L. & Rose, J. D. in Brain Corticosteroid Receptors(eds De Kloet, E. R., Azmitia, E. C. & Landfield, P. W.) 101–114 (Ann. NY Acad. Sci. 746, (1994)).
Cited by
Sorted by citations
Items 301–400 of 999
Bentz, D., Michael, T., Wilhelm, F. H., Hartmann, F., Kunz, S., von Rohr, I. R. R., & de Quervain, D. J. ‐. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.12.018 · Cited by 81
Krugers, H. J., Karst, H., & Joëls, M. (2012) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2012.00015 · Cited by 84
“Exposure to stress and elevated corticosteroid levels hamper the retrieval of already stored information (De Quervain et al., 1998).”
Yang, Y., Zheng, X., Wang, Y., Cao, J., Dong, Z., Cai, J., Sui, N., & Xu, L. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5544-03.2004 · Cited by 77
Kiank, C., Holtfreter, B., Starke, A., Mundt, A., Wilke, C., & Schütt, C. (2006) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2005.10.151 · Cited by 76
Testosterone and Adult Neurogenesis
Spritzer, M. D., & Roy, E. A. (2020) · Biomolecules · doi:10.3390/biom10020225 · Cited by 81
“A variety of chronic stressors impair spatial working and reference memory in rodents [210–212], and the negative effects of stress on spatial memory seem to be caused by corticosterone binding to receptors in the hippocampus [213,214].”
BackgroundSetlow, B., Roozendaal, B., & McGaugh, J. L. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00911.x · Cited by 76
Self-citationChen, K., Zhang, L., Tan, M., Lai, C. S. W., Li, A., Ren, C., & So, K. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.41 · Cited by 79
Effect of chronic stress on spatial memory in rats is attenuated by lithium treatment
de Vasconcellos, A. P. S., Tabajara, Â. S., Ferrari, C., Rocha, E., & Dalmaz, C. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00113-6 · Cited by 75
Regulation of Neuronal Cell Adhesion Molecule Expression by NF-κB
Simpson, C. S., & MORRIS, B. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.22.16879 · Cited by 73
Context Learning and the Effect of Context on Memory Retrieval in LymnaeaPreprint
Haney, J. J., & Lukowiak, K. (2001) · Learning & Memory · doi:10.1101/lm.34701 · Cited by 75
Baker, J. D., McMillan, I. O., Ospina, S. R., Gulick, D., & Blair, L. J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010079 · Cited by 74
“Dysregulation of CORT levels, whether positive or negative, can impair memory consolidation [17].”
BackgroundGlucocorticoids and the Brain after Critical Illness
Hill, A. R., & Spencer-Segal, J. L. (2021) · Endocrinology · doi:10.1210/endocr/bqaa242 · Cited by 79
“Glucocorticoids are also timing dependent; elevated levels immediately before retention testing hampers the retrieval of contextual fear-conditioned memory and inhibitory avoidance memory (99).”
Post-traumatic stress disorder in somatic disease: lessons from critically ill patients.
Schelling, G. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(07)67016-2 · Cited by 68
Skórzewska, A., Bidziński, A., Lehner, M., Turzyńska, D., Wisłowska-Stanek, A., Sobolewska, A., Szyndler, J., Maciejak, P., Taracha, E., & Płaźnik, A. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.10.001 · Cited by 74
Monk, C. S. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00384-0 · Cited by 72
“Furthermore, consistent with de Quervain and colleagues’ human work described above (de Quervain et al. 2000), rats were impaired in retrieval memory for a water maze when corticosterone was administered 30 min before test (de Quervain et al. 1998).”
ResultInsulin protects against stress-induced impairments in water maze performance
Moosavi, M., Naghdi, N., Maghsoudi, N., & Zahediasl, S. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.10.011 · Cited by 74
Rapid Effects of Corticosterone on Cache Recovery in Mountain Chickadees (Parus gambeli)
Saldanha, C. J., Schlinger, B. A., & Clayton, N. S. (2000) · Hormones and Behavior · doi:10.1006/hbeh.2000.1571 · Cited by 74
Zhao, L., Zhang, X., Shi, J., Epstein, D. H., & Lü, L. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1406-2 · Cited by 73
“Stress or glucocorticoids have shown an inverse U-shaped dose– response relationship with consolidation (Lupien and McEwen 1997; Sandi et al. 1997; Roozendaal et al. 1999) and an inhibitory effect on retrieval (de Quervain et al. 1998; Roozendaal et al. 2002).”
THE EFFECT OF CHRONIC RESTRAINT STRESS ON SPATIAL LEARNING AND MEMORY: RELATION TO OXIDANT STRESS
Abidin, İ., Yargıçoğlu, P., Ağar, A., Gümüşlü, S., Aydın-Abidin, S., Aydın-Abidin, S., Öztürk, O., & Şahın, E. (2004) · International Journal of Neuroscience · doi:10.1080/00207450490430543 · Cited by 74
“It has been suggested that effects of stress on learning might be related to corticosterone levels (De Kloet, Oitzl, & Joels, 1999; De Quervain et al., 1998).”
BackgroundBahtiyar, S., Karaca, K. G., Henckens, M. J. A. G., & Roozendaal, B. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2020.103537 · Cited by 80
Self-citationBlockade of caspase‐1 increases neurogenesis in the aged hippocampus
Gemma, C., Bachstetter, A. D., Cole, M. J., Fister, M. C., Hudson, C., & Bickford, P. C. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05875.x · Cited by 74
Rashidy‐Pour, A., Sadeghi, H., Taherain, A. A., Vafaei, A. A., & Fathollahi, Y. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.02.007 · Cited by 73
Brabham, T., Phelka, A., Zimmer, C. A., Nash, A., López, J. F., & Vázquez, D. M. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.5.r1899 · Cited by 73
Zorawski, M. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2002.4075 · Cited by 72
Wiegert, O., Pu, Z., Shor, S., Joëls, M., & Krugers, H. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.05.039 · Cited by 87
Liang, H., Lu, F., Shi, Y., Nanjappan, V., & Papangelis, K. (2018) · Future Generation Computer Systems · doi:10.1016/j.future.2018.02.029 · Cited by 74
Ferguson, D., & Sapolsky, R. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1187-07.2007 · Cited by 71
“These results are consistent with data indicating that glucocorticoids or stress administered to rats or humans before retention testing impair retrieval of long-term memory (de Quervain et al., 1998, 2000).”
BackgroundResultNo Retrieval-Induced Forgetting Under Stress
Koessler, S., Engler, H., Riether, C., & Kissler, J. M. (2009) · Psychological Science · doi:10.1111/j.1467-9280.2009.02450.x · Cited by 72
“Although the experience of stress shortly before retrieval impairs recall performance for well-consolidated memories (de Quervain et al., 1998; Kuhlmann, Piel, & Wolf, 2005), no such impairment was observed in the present study.”
BackgroundMolecular Mechanisms of Memory Retrieval
Szapiro, G., Galante, J., Barros, D. M., de Stein, M. L., Vianna, M. R. M. R., Izquierdo, L. A., Izquierdo, I., & Medina, J. H. (2002) · Neurochemical Research · doi:10.1023/a:1021648405461 · Cited by 74
Glucocorticoid-induced reduction of traumatic memories: implications for the treatment of PTSD
de Quervain, D. J. ‐. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)67017-4 · Cited by 71
Almaguer‐Melian, W., Bergado, J. A., Fuentes, N. P., Alberti‐Amador, E., Mercerón‐Martínez, D., & Frey, J. U. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114198109 · Cited by 71
“FS can directly affect retrieval of a consolidated memory trace only in a short period (less than 30 min) but not after 4 h (20).”
BackgroundMorena, M., Castro, V. D., Gray, J. M., Palmery, M., Trezza, V., Roozendaal, B., Hill, M. N., & Campolongo, P. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1983-15.2015 · Cited by 71
“Stress or exogenous glucocorticoid administration typically impairs memory retrieval of contextual/spatial information in rats and declarative information in humans (de Quervain et al., 1998; Roozendaal et al., 2003, 2004a; de Quervain et al., 2009).”
BackgroundSelf-citationMiranda, M. I., Quirarte, G. L., Rodríguez-García, G., McGaugh, J. L., & Roozendaal, B. (2008) · Learning & Memory · doi:10.1101/lm.964708 · Cited by 70
Self-citationAcute psychosocial stress effects on memory performance: Relevance of age and sex
Hidalgo, V., Pulopulos, M. M., & Salvador, A. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.11.013 · Cited by 80
Ramin, M., Azizi, P., Motamedi, F., Haghparast, A., & Khodagholi, F. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.11.017 · Cited by 71
Glucocorticoid‐Induced Inhibition of Memory Retrieval
de Quervain, D. J. ‐. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.016 · Cited by 69
Stress Impairs Episodic Retrieval by Disrupting Hippocampal and Cortical Mechanisms of Remembering
Gagnon, S. A., Waskom, M. L., Brown, T. I., & Wagner, A. D. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhy162 · Cited by 69
Abrari, K., Rashidy‐Pour, A., Semnanian, S., & Fathollahi, Y. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.10.008 · Cited by 68
Kanamaru, Y., Kikukawa, A., & Shimamura, K. (2006) · Stress · doi:10.1080/14769670600909594 · Cited by 68
“This test battery has been used extensively by defense research laboratories (Callister et al. 1996; de Quervain et al. 1998; Taylor et al. 2000).”
MethodTropisetron attenuates amyloid‐beta‐induced inflammatory and apoptotic responses in rats
Rahimian, R., Fakhfouri, G., Mehr, S. E., Ghia, J., Genazzani, A. A., Payandemehr, B., Dehpour, A. R., Mousavizadeh, K., & Lim, D. (2013) · European Journal of Clinical Investigation · doi:10.1111/eci.12141 · Cited by 68
Quaedflieg, C. W. E. M., Schwabe, L., Meyer, T., & Smeets, T. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.09.002 · Cited by 70
“In particular, stress can facilitate memory consolidation (e.g., Cahill et al., 2003; Smeets et al., 2008), whereas stress before retention testing typically impairs memory retrieval (e.g., de Quervain et al., 1998; Kuhlmann et al., 2005).”
Implications of Hypothalamic–Pituitary–Adrenal Axis Functioning in Posttraumatic Stress Disorder
Jones, T., & Moller, M. D. (2011) · Journal of the American Psychiatric Nurses Association · doi:10.1177/1078390311420564 · Cited by 67
Effect of neonatal handling on adult rat spatial learning and memory following acute stress
Stamatakis, A., Stamatakis, A., Pondiki, S., Stamatakis, A., Pondiki, S., Kitraki, E., Diamantopoulou, A., Panagiotaropoulos, T. I., Raftogianni, A., & Stylianopoulou, F. (2008) · Stress · doi:10.1080/10253890701653039 · Cited by 70
“…trained to find the hidden platform (in a fixed position relative to visible extra-maze cues) according to an intense, one-day long protocol (de Quervain et al. 1998), composed of eight consecutive 90 s learning trials, each beginning at a different starting position with the four possible…”
BackgroundMethodInfluentialEffect of examination stress on mood, performance and cortisol levels in medical students.
Singh, R., Goyal, M. K., Tiwari, S., Ghildiyal, A., Nattu, S. M., & Das, S. S. (2012) · PubMed · Cited by 67
Cain, D. P., Boon, F. H., & Corcoran, M. E. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.02.023 · Cited by 65
Knapman, A., Heinzmann, J.-M., Hellweg, R., Holsboer, F., Landgraf, R., & Touma, C. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.11.014 · Cited by 69
“…are believed to enhance memory consolidation, whereas increased glucocorticoid levels impair memory retrieval (Buchanan and Lovallo, 2001; de Quervain et al., 1998; Flood et al., 1978; Holsboer and Ising, 2010; Kovacs et al., 1977; Kuhlmann and Wolf, 2006; Oitzl et al., 1998; Roozendaal,…”
BackgroundDecision-making, financial risk aversion, and behavioral biases: The role of testosterone and stress
Nofsinger, J. R., Patterson, F., & Shank, C. A. (2018) · Economics & Human Biology · doi:10.1016/j.ehb.2018.01.003 · Cited by 66
“Furthermore, these results are consistent with the medical literature showing that higher stress levels are related to a plethora of cognitive errors (McEwen and Sapolsky, 1995; Sapolsky, 1996; Dominique et al., 1998; Lupien et al., 2009).”
InfluentialSuppressing the morning rise in cortisol impairs free recallPreprint
Rimmele, U., Meier, F., Lange, T., & Jan Born, A. (2010) · Learning & Memory · doi:10.1101/lm.1728510 · Cited by 69
Effects of acute restraint stress on set-shifting and reversal learning in male rats
Thai, C. A., Zhang, Y., & Howland, J. G. (2013) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-012-0124-8 · Cited by 65
Howland, J. G., & Cazakoff, B. N. (2009) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2009.10.006 · Cited by 65
“…effects of acute stress on spatial memory retrieval depend at least in part on elevations in corticosterone acting on glucocorticoid receptors (de Quervain et al., 1998; but see also Woodson, Macintosh, Fleshner, and Diamond (2003)) and may be a direct result of alterations in patterns of…”
BackgroundHuang, Y. Y., Zhou, W., & Zhang, Y. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.08.043 · Cited by 65
Glucocorticoids and cognitive function: from physiology to pathophysiology
Jameison, K., & Dinan, T. G. (2001) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.304 · Cited by 66
Power, A. E., Roozendaal, B., & McGaugh, J. L. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00224.x · Cited by 65
Self-citationNovelty enhances retrieval: molecular mechanisms involved in rat hippocampus
Izquierdo, L. A., Viola, H., Barros, D. M., Alonso, M., Vianna, M. R. M. R., Furman, M., de Stein, M. L., Szapiro, G., Rodrigues, C., Choi, H., et al. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01530.x · Cited by 65
“In contrast, the facilitating effect of novelty on memory retrieval does not seem to be due to stress as stress and glucocorticoids impair retrieval in a time-dependent manner (De Quervain et al., 1998).”
BackgroundRole of glucocorticoids in dopamine-related neuropsychiatric disorders
Craenenbroeck, K. V., Bosscher, K. D., Berghe, W. V., Vanhoenacker, P., & Haegeman, G. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.10.007 · Cited by 64
Stress impairs retrieval of socially relevant information.
Merz, C. J., Wolf, O. T., & Hennig, J. (2010) · Behavioral Neuroscience · doi:10.1037/a0018942 · Cited by 63
Yeh, Y., Lai, G.-J., Lin, C. F., Lin, C.-W., & Sun, H.-C. (2014) · Computers & Education · doi:10.1016/j.compedu.2014.09.011 · Cited by 66
Rabiei, Z., Rafieian‐Kopaei, M., Mokhtari, S., Alibabaei, Z., & Shahrani, M. (2013) · Biomedicine & Aging Pathology · doi:10.1016/j.biomag.2013.10.006 · Cited by 63
Neuromodulatory signaling in hippocampus‐dependent memory retrieval
THOMAS, S. A. (2014) · Hippocampus · doi:10.1002/hipo.22394 · Cited by 64
“When administered shortly before testing, they impair the retrieval of spatial reference memory in rats and free word recall in humans (de Quervain et al., 1998; de Quervain et al., 2000; Kuhlmann et al., 2005).”
BackgroundAnimal Memory and Animal Welfare
Mendl, M., Burman, O. H. P., Laughlin, K., & Paul, E. S. (2001) · Animal Welfare · doi:10.1017/s0962728600023587 · Cited by 64
Schelling, G. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2002.4083 · Cited by 66
Wolf, O. T., Schommer, N. C., Hellhammer, D. H., Reischies, F. M., & Kirschbaum, C. (2002) · Stress · doi:10.1080/102538902900012332 · Cited by 62
“Recent studies in rats have demonstrated that stress, as well as corticosterone treatment, impairs 24 h delayed recall in the water maze (de Quervain et al., 1998).”
BackgroundResultRiedemann, T., Patchev, A. V., Cho, K., & Almeida, O. F. X. (2010) · Molecular Brain · doi:10.1186/1756-6606-3-2 · Cited by 65
“Additional file 1: Summary of rapid effects of corticosteroids and estrogens on the central nervous system [148-181].”
BackgroundBehen, M. E., Helder, E. J., Rothermel, R., Solomon, K. M., & Chugani, H. T. (2008) · Child Neuropsychology · doi:10.1080/09297040802244136 · Cited by 65
“Several studies have demonstrated adverse effects of stress on episodic and spatial memory in animals and humans ( de Quervain, Roozendaal, & McGaugh, 1998 ; Lupien & McEwen, 1997 ), as well as prolonged stress on cognitive dysfunction ( McEwen & Sapolsky, 1995 ).”
BackgroundIl-Han, J., Janes, T. A., & Lukowiak, K. (2010) · Journal of Experimental Biology · doi:10.1242/jeb.048256 · Cited by 62
“Depending on the specific stressor and how the stress is perceived, memory formation and/or its recall may be enhanced or impaired (de Quervain et al., 1998; Cahill et al., 2003; Joels et al., 2006; Lukowiak et al., 2008).”
BackgroundSchönfeld, P., Ackermann, K., & Schwabe, L. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.09.020 · Cited by 66
Cohen, S., Kozlovsky, N., Matar, M. A., Kaplan, Z., Zohar, J., & Cohen, H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.94 · Cited by 62
Zhang, L., Li, H., Su, T.-P., Barker, J. L., Maric, D., Fullerton, C. S., Webster, M. J., Hough, C. J., Li, X., & Ursano, R. J. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.03.022 · Cited by 62
Morales‐Medina, J. C., Juárez, I., Venancio-García, E., Cabrera, S. N., Ménard, C., Yu, W., Flores, G., Mechawar, N., & Quirion, R. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.037 · Cited by 62
“For example, repeated stress or CORT treatment induced both hippocampal hypotrophy and deficits in navigation memory (Conrad et al., 1996; de Quervain et al., 1998; Sousa et al., 2000).”
Rapid stress‐induced corticosterone rise in the hippocampus reverses serial memory retrieval pattern
Chauveau, F., Tronche, C., Piérard, C., Liscia, P., Drouet, I., Coutan, M., & Béracochéa, D. (2009) · Hippocampus · doi:10.1002/hipo.20605 · Cited by 60
Hawley, W. R., Grissom, E. M., Moody, N. M., Dohanich, G. P., & Vasudevan, N. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.01.006 · Cited by 61
Yang, Y., Cao, J., Xiong, W., Zhang, J., Zhou, Q., Wei, H., Liang, C., Deng, J., Li, T., Yang, S., et al. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1780045 · Cited by 61
“…the rats on an elevated platform (EP) in the middle of a brightly lit room for 30 min (Balfour & Reid 1979, Xu et al. 1997) or by giving foot shocks (F, 0·8 mA for 1 s with a 5-s inter-shock interval) in an operant test chamber (Med Associates Inc., St Albans, Herts, UK) (de Quervain et al. 1998).”
BackgroundTeather, L. A., Magnusson, J. E., Chow, C. M., & Wurtman, R. J. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02416.x · Cited by 60
“Male EC rats displayed a different behavioural response to formalin during the in¯ammatory phase of nociception ± the phase affected by hippocampal processing; a similar trend was observed in females.”
BackgroundResultCohen, O., Erb, C., Ginzberg, D., Pollak, Y., Seidman, S., Shoham, S., Yirmiya, R., & Soreq, H. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001103 · Cited by 61
Stress response recruits the hippocampal endocannabinoid system for the modulation of fear memoryPreprint
Alvares, L. D. O., Engelke, D. S., Diehl, F., Scheffer-Teixeira, R., Haubrich, J., Cassini, L. F., Molina, V. A., & Quillfeldt, J. A. (2010) · Learning & Memory · doi:10.1101/lm.1721010 · Cited by 61
“…is widely known that stressful events, such as an aversive learning paradigm, or the release of hormones functionally associated with threatening events, play a critical role in memory processes (Roozendaal and McGaugh 1996; de Quervain et al. 1998; Roozendaal et al. 1999, 2003; Okuda et al. 2004).”
BackgroundStress promotes generalization of older but not recent threat memories
Dunsmoor, J. E., Otto, A. R., & Phelps, E. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1704428114 · Cited by 61
“As stress has been shown to modulate retrieval of hippocampal (48) and amygdala-dependent (40) memories, one possibility is that stress-induction impaired retrieval of the precise CS+ memory in experiment 2, thereby altering the generalization gradient.”
BackgroundEcologically relevant stressors modify long-term memory formation in a model system
Lukowiak, K., Orr, M., Caigny, P. D., Lukowiak, K. S., Rosenegger, D. G., Han, J. I., & Dalesman, S. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.05.011 · Cited by 59
“[7–10]).”
Benvéniste, O., Jacobson, L. W., Farrugia, M. E., Clover, L. M., & Vincent, A. C. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.08.016 · Cited by 62
Stress impairs spatial but not early stimulus–response learning
Schwabe, L., Schächinger, H., de Kloet, E. R., & Oitzl, M. S. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.04.029 · Cited by 66
“Most studies describe stress- or GC-induced changes in spatial/declarativememory, amemory system that is based on information processing in the hippocampus and adjacent cortices [6–10].”
BackgroundThe Impact of Stress and Glucocorticoids on Memory
Tatomir, A., Micu, C. M., & Crivii, C. B. (2014) · Medicine and Pharmacy Reports · doi:10.15386/cjm.2014.8872.871.at1cm2 · Cited by 62
Khaksari, M., Rashidy‐Pour, A., & Vafaei, A. A. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.08.016 · Cited by 62
“…that tress and glucocorticoids also impair retrieval of previusly acquired information including contextual/spatial inormation in animals (de Quervain et al., 1998; Pakdel and ashidy-Pour, 2006; Sajadi et al., 2006 and 2007) and eclarative/episodic information in humans (de Quervain t al.,…”
BackgroundTürkmen, Ş., Lundgren, P., Birzniece, V., Zingmark, E., Bäckström, T. C., & Johansson, I. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03610.x · Cited by 60
“Allopregnanolone also increases during stress (Purdy et al., 1991), and stress is related to impaired cognitive function (de Quervain et al., 1998).”
BackgroundAging and stress: past hypotheses, present approaches and perspectives.
Garrido, P. (2011) · Europe PMC (PubMed Central) · Cited by 61
Ashabi, G., Ramin, M., Azizi, P., Taslimi, Z., Alamdary, S. Z., Haghparast, A., Ansari, N., Motamedi, F., & Khodagholi, F. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.04.006 · Cited by 58
Role of Nuclear Receptors in Central Nervous System Development and Associated Diseases
Maria, A. A., Moreno-Ramos, O. A., & Haider, N. B. (2015) · Journal of Experimental Neuroscience · doi:10.4137/jen.s25480 · Cited by 63
Gingko biloba extract diminishes stress-induced memory deficits in rats.
Walesiuk, A., Trofimiuk, E., & Braszko, J. J. (2005) · PubMed · Cited by 59
Dorey, R., Piérard, C., Shinkaruk, S., Tronche, C., Chauveau, F., Baudonnat, M., & Béracochéa, D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.152 · Cited by 59
Copeptin as a stress marker prior and after a written examination – the CoEXAM study
Urwyler, S. A., Schüetz, P., Sailer, C. O., & Christ‐Crain, M. (2014) · Stress · doi:10.3109/10253890.2014.993966 · Cited by 58
“For example, healthy volunteers treated with 25 mg cortisone were significantly worse in recalling information relative to placebo controls (de Quervain et al., 1998).”
BackgroundExamination Stress, Salivary Cortisol, and Academic Performance
Ng, V., Koh, D. S. Q., & Chia, S. E. (2003) · Psychological Reports · doi:10.2466/pr0.2003.93.3f.1133 · Cited by 58
“Secondly, raised cortisol levels may affect the efficacy or accuracy of the information retrieval mechanism (3) in recalling information studied for the examination, thereby affecting examination performance.”
BackgroundCazakoff, B. N., & Howland, J. G. (2009) · Hippocampus · doi:10.1002/hipo.20738 · Cited by 61
“Numerous reports have shown acute stress disrupts hippocampal-dependent learning and memory (Diamond et al., 1996; de Quervain et al., 1998; Wong et al., 2007) and provide evidence that alterations in long-term synaptic plasticity are necessary for the deficits in spatial cognition typically…”
BackgroundBrain organic cation transporter 2 controls response and vulnerability to stress and GSK3β signaling
Couroussé, T., Bacq, A., Belzung, C., Guiard, B. P., Balasse, L., Louis, F., Guisquet, A.-M. L., Gardier, A. M., Schinkel, A. H., Giros, B., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.86 · Cited by 62
Alzoubi, K. H., Abdul‐Razzak, K. K., Khabour, O. F., Al-Tuweiq, G. M., Alzubi, M. A., & Alkadhi, K. A. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.09.018 · Cited by 58
Long-term effects of prior cocaine exposure on Morris water maze performance
Mendez, I. A., Montgomery, K. S., LaSarge, C. L., Simon, N. W., Bizon, J. L., & Setlow, B. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.08.005 · Cited by 60
The Douglas Hospital Longitudinal Study of Normal and Pathological Aging: summary of findings
LUPIEN, S. J., Schwartz, G., Ng, Y. K., Fiocco, A. J., Wan, N., Pruessner, J. C., Meaney, M. J., & Nair, N. P. V. (2005) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0542 · Cited by 57
Schutsky, K., Ouyang, M., Castelino, C. B., Zhang, L., & THOMAS, S. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2122-11.2011 · Cited by 59
“When administered shortly before testing, they impair the retrieval of hippocampus-dependent memory (de Quervain et al., 1998, 2000; Kuhlmann et al., 2005).”
BackgroundMethodTestosterone modulates spatial recognition memory in male rats.
Hawley, W. R., Grissom, E. M., Martin, R. C., Halmos, M. B., Bart, C., & Dohanich, G. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.02.007 · Cited by 59
c-Jun N-terminal kinases in memory and synaptic plasticity
Sherrin, T., Blank, T., & Todorovic, C. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.032 · Cited by 56
Memory-improving activity of Melissa officinalis extract in naïve and scopolamine-treated rats.
Soodi, M., Naghdi, N., Hajimehdipoor, H., Choopani, S., & Sahraei, E. (2014) · Europe PMC (PubMed Central) · Cited by 56
Imaging Stress Effects on Memory: A Review of Neuroimaging Studies
van Stegeren, A. H. (2009) · The Canadian Journal of Psychiatry · doi:10.1177/070674370905400105 · Cited by 56
Macartney, E. L., Lagisz, M., & Nakagawa, S. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104554 · Cited by 61
Metadata
- Authors
- de Quervain, D. J.-F., Roozendaal, B., & McGaugh, J. L.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Roozendaal, Benno
- Venue
- Nature
- Published
- 1998-08
- Volume
- 394
- Issue
- 6695
- Pages
- 787-790
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1724698019
- Cited by
- 1,182
- References
- 22
- Citations by year
- 2026: 28 · 2025: 21 · 2024: 27 · 2023: 15 · 2022: 26 · 2021: 25 · 2020: 37 · 2019: 39 · 2018: 52 · 2017: 51 · 2016: 46 · 2015: 47 · 2014: 54 · 2013: 73 · 2012: 58
- FWCI
- 17.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- stress, glucocorticoids, corticosterone, memory retrieval, long-term spatial memory, water maze, footshock, metyrapone, adrenocortical function, memory consolidation, memory acquisition, spatial navigation
- MeSH terms
- Animals, Glucocorticoids, Hypothalamo-Hypophyseal System, Male, Memory Disorders, Pituitary-Adrenal System, Retention, Psychology, Stress, Physiological, Rats, Sprague-Dawley, Maze Learning, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
