Cited by 1,182Memory and Neural MechanismsStress Responses and CortisolMemory Processes and Influences

The DOI matches its Crossref record; 21 of the 22 references it cites were found in a registry or an index.

Stress and glucocorticoids impair retrieval of long-term spatial memory

de Quervain, Dominique J.-F., Roozendaal, Benno, McGaugh, James L.·1998·Nature

Open this paper in CoChat — free account

Abstract

Extensive evidence from animal and human studies indicates that stress and glucocorticoids influence cognitive function. Previous studies have focused exclusively on glucocorticoid effects on acquisition and long-term storage of newly acquired information. Here we report that stress and glucocorticoids also affect memory retrieval. We show that rats have impaired performance in a water-maze spatial task after being given footshock 30 min before retention testing but are not impaired when footshock is given 2 min or 4 h before testing. These time-dependent effects on retention performance correspond to the circulating corticosterone levels at the time of testing, which suggests that the retention impairment is directly related to increased adrenocortical function. In support of this idea, we find that suppression of corticosterone synthesis with metyrapone blocks the stress-induced retention impairment. In addition, systemic corticosterone administered to non-stressed rats 30 min before retention testing induces dose-dependent retention impairment. The impairing effects of stress and glucocorticoids on retention are not due to disruption of spatial navigation per se. Our results indicate that besides the well described effects of stress and glucocorticoids on acquisition and consolidation processes, glucocorticoids also affect memory retrieval mechanisms.

Integrity signals

Registry

Crossref · 10.1038/29542

Cites

21 of 21 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Developments of a water-maze procedure for studying spatial learning in the rat
Morris, R. (1984) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(84)90007-4 · Cited by 7,180
The acute effects of corticosteroids on cognition: integration of animal and human model studies
LUPIEN, S., & MCEWEN, B. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00004-0 · Cited by 1,024
Brain corticosteroid receptor balance and homeostatic control
de Kloet, E. R. (1991) · Frontiers in Neuroendocrinology · Cited by 842
Stress- and treatment-induced elevations of cortisol levels associated with impaired declarative memory in healthy adults
Kirschbaum, C., Wolf, O. T., May, M., Wippich, W., & Hellhammer, D. H. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00118-x · Cited by 815
Repeated stress causes reversible impairments of spatial memory performance.
Luine, V., Villegas, M., Martinez, C., & McEwen, B. (1994) · Brain Research · doi:10.1016/0006-8993(94)91778-7 · Cited by 813
Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine pretreatment.
Conrad, C. D., Galea, L. A. M., Kuroda, Y., & McEwen, B. S. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.6.1321 · Cited by 805
Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning.
Oitzl, M. S., & de Kloet, E. R. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.1.62 · Cited by 649
Experience-dependent facilitating effect of corticosterone on spatial memory formation in the water maze
Sandi, C., Loscertales, M., & Guaza, C. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01412.x · Cited by 447
Glucocorticoid-induced impairment in declarative memory performance in adult humans
Newcomer, J., Craft, S., Hershey, T., Askins, K., & Bardgett, M. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-04-02047.1994 · Cited by 441
Stress-Induced Declarative Memory Impairment in Healthy Elderly Subjects: Relationship to Cortisol Reactivity
LUPIEN, S. J., Gaudreau, S., Tchiteya, B. M., Maheu, F. S., Sharma, S., Nair, N. P. V., Hauger, R. L., McEwen, B. S., & Meaney, M. J. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.7.4075 · Cited by 394

Flagged first, then by citations

Show all 22 references

1 of the 22 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Orchinik, M., Moore, F. L. & Rose, J. D. in Brain Corticosteroid Receptors(eds De Kloet, E. R., Azmitia, E. C. & Landfield, P. W.) 101–114 (Ann. NY Acad. Sci. 746, (1994)).

Sorted by citations

Items 101–200 of 999

The Basolateral Amygdala Interacts with the Medial Prefrontal Cortex in Regulating Glucocorticoid Effects on Working Memory Impairment
Roozendaal, B., McReynolds, J. R., & McGaugh, J. L. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4664-03.2004 · Cited by 327
Self-citation
Postreactivation Glucocorticoids Impair Recall of Established Fear Memory
Cai, W.-H., Blundell, J. J., Han, J., Greene, R. W., & Powell, C. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2397-06.2006 · Cited by 249
Lipopolysaccharide causes deficits in spatial learning in the watermaze but not in BDNF expression in the rat dentate gyrus
Shaw, K. N. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00232-7 · Cited by 241
Chapter 8 Synaptic plasticity in learning and memory: Stress effects in the hippocampus
Howland, J. G., & Wang, Y. T. (2008) · Progress in brain research · doi:10.1016/s0079-6123(07)00008-8 · Cited by 243
Resilience Training Program Reduces Physiological and Psychological Stress in Police Officers
Mccraty, R., & Atkinson, M. (2012) · Global Advances in Health and Medicine · doi:10.7453/gahmj.2012.1.5.013 · Cited by 234
The influence of stress hormones on emotional memory: Relevance for psychopathology
Wolf, O. T. (2007) · Acta Psychologica · doi:10.1016/j.actpsy.2007.08.002 · Cited by 244
Acute stress and episodic memory retrieval: neurobiological mechanisms and behavioral consequences
Gagnon, S. A., & Wagner, A. D. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12996 · Cited by 255
The Microbiome in Psychology and Cognitive Neuroscience
Sarkar, A., Harty, S., Lehto, S. M., Moeller, A. H., Dinan, T. G., Dunbar, R., Cryan, J. F., & Burnet, P. W. J. (2018) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2018.04.006 · Cited by 238
Membrane-associated glucocorticoid activity is necessary for modulation of long-term memory via chromatin modification
Roozendaal, B., Hernandez, A., Cabrera, S. M., Hagewoud, R., Malvaez, M., Stefanko, D. P., Haettig, J., & Wood, M. A. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5717-09.2010 · Cited by 233
Self-citation
Dendritic Spine Plasticity: Function and Mechanisms
Runge, K., Cardoso, C., & de Chevigny, A. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.00036 · Cited by 248
Brain insulin signaling: A key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes
McNay, E. C., & Recknagel, A. K. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.08.005 · Cited by 233
Evaluation of spatial memory of C57BL/6J and CD1 mice in the Barnes maze, the Multiple T-maze and in the Morris water maze
Patil, S. S., Sunyer, B., Höger, H., & Lübec, G. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.10.029 · Cited by 235
Contribution of sex differences in the acute stress response to sex differences in water maze performance in the rat
Beiko, J., Lander, R., Hampson, E., Boon, F. H., & Cain, D. P. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.08.019 · Cited by 232
Chronic stress modulates the use of spatial and stimulus-response learning strategies in mice and man
Schwabe, L., Dalm, S., Schächinger, H., & Oitzl, M. S. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.07.015 · Cited by 228
HPA axis and memory
Wolf, O. T. (2003) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/s1521-690x(02)00101-x · Cited by 231
Stressful Experience and Learning Across the Lifespan
Shors, T. J. (2005) · Annual Review of Psychology · doi:10.1146/annurev.psych.57.102904.190205 · Cited by 234
Hippocampal long-term depression mediates acute stress-induced spatial memory retrieval impairment
Wong, T. P., Howland, J. G., Robillard, J. M., Ge, Y., Yu, W. K., Titterness, A. K., Brebner, K., Liu, L., Weinberg, J., Christie, B. R., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702308104 · Cited by 228
Interacting brain systems modulate memory consolidation
McIntyre, C. K., McGaugh, J. L., & Williams, C. L. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.11.001 · Cited by 243
Self-citation
Basolateral amygdala noradrenergic influence enables enhancement of memory consolidation induced by hippocampal glucocorticoid receptor activation
Roozendaal, B., Nguyen, B. T., Power, A. E., & McGaugh, J. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11642 · Cited by 293
Self-citation
Corticosteroids Operate as a Switch between Memory Systems
Schwabe, L., Schächinger, H., de Kloet, E. R., & Oitzl, M. S. (2009) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21278 · Cited by 225
Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect
Jeanneteau, F., Garabedian, M. J., & Chao, M. V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709102105 · Cited by 215
Influence of predator stress on the consolidation versus retrieval of long-term spatial memory and hippocampal spinogenesis
Diamond, D. M., Campbell, A. M., Park, C. R., Woodson, J. C., Conrad, C. D., Bachstetter, A. D., & Mervis, R. F. (2006) · Hippocampus · doi:10.1002/hipo.20188 · Cited by 213
Cortisol differentially affects memory in young and elderly men.
Wolf, O. T., Convit, A. J., McHugh, P. F., Kandil, E., Thorn, E. L., Santi, S. D., McEwen, B. S., & de Leon, M. J. (2001) · Behavioral Neuroscience · doi:10.1037//0735-7044.115.5.1002 · Cited by 220
From Receptor Balance to Rational Glucocorticoid Therapy
de Kloet, E. R. (2014) · Endocrinology · doi:10.1210/en.2014-1048 · Cited by 211
Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala
Johnson, L. R., Farb, C., Morrison, J. H., McEwen, B. S., & Ledoux, J. E. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.050 · Cited by 205
Cognitive Adaptation under Stress: A Case for the Mineralocorticoid Receptor
Vogel, S., Fernández, G., Joëls, M., & Schwabe, L. (2016) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.12.003 · Cited by 215
The effects of non-genomic glucocorticoid mechanisms on bodily functions and the central neural system. A critical evaluation of findings
Haller, J., Mikics, É., & Makara, G. B. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.10.004 · Cited by 208
Defeat followed by individual housing results in long-term impaired reward- and cognition-related behaviours in rats
von Frijtag, J. C., Reijmers, L. G. J. E., van der Harst, J. E., Leus, I. E., van den Bos, R., & Spruijt, B. M. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00300-4 · Cited by 201
Early Post-Stressor Intervention with High-Dose Corticosterone Attenuates Posttraumatic Stress Response in an Animal Model of Posttraumatic Stress Disorder
Cohen, H., Matar, M. A., Buskila, D., Kaplan, Z., & Zohar, J. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.025 · Cited by 200
Intestinal Epithelial Cells Synthesize Glucocorticoids and Regulate T Cell Activation
Cima, I., Corazza, N., Dick, B., Fuhrer, A. C., Herren, S., Jakob, S., Ayuni, E., Mueller, C., & Brunner, T. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031958 · Cited by 206
Stress hormones and AMPA receptor trafficking in synaptic plasticity and memory
Krugers, H. J., Hoogenraad, C. C., & Groc, L. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2913 · Cited by 197
The contribution of adrenal and reproductive hormones to the opposing effects of stress on trace conditioning males versus females.
Wood, G. E., Beylin, A. V., & Shors, T. J. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.1.175 · Cited by 198
Neurosteroids and GABA-A Receptor Function
Wang, M. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00044 · Cited by 207
Corticosteroid Actions in the Hippocampus
Joëls, M. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00688.x · Cited by 196
Arousal and cortisol interact in modulating memory consolidation in healthy young men.
Kuhlmann, S., & Wolf, O. T. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.1.217 · Cited by 194
Reduced hippocampal and amygdala activity predicts memory distortions for trauma reminders in combat-related PTSD
Hayes, J. P., LaBar, K. S., McCarthy, G., Selgrade, E. S., Nasser, J. D., Dolcos, F., & Morey, R. A. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.10.007 · Cited by 190
Amygdala-Hippocampus Dynamic Interaction in Relation to Memory
Richter‐Levin, G., & Akirav, I. (2000) · Molecular Neurobiology · doi:10.1385/mn:22:1-3:011 · Cited by 204
Effects of pre-learning stress on memory for neutral, positive and negative words: Different roles of cortisol and autonomic arousal
Schwabe, L., Böhringer, A., Chatterjee, M. B., & Schächinger, H. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.02.002 · Cited by 194
Mechanisms of memory under stress
Schwabe, L., Hermans, E. J., Joëls, M., & Roozendaal, B. (2022) · Neuron · doi:10.1016/j.neuron.2022.02.020 · Cited by 206
Self-citation
Lack of tissue glucocorticoid reactivation in 11β-hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments
Yau, J. L. W., Noble, J., Kenyon, C. J., Hibberd, C. J., Kotelevtsev, Y. V., Mullins, J. J., & Seckl, J. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071562698 · Cited by 190
Behavioural pharmacology and its contribution to the molecular basis of memory consolidation
Izquierdo, I., & McGaugh, J. L. (2000) · Behavioural Pharmacology · doi:10.1097/00008877-200011000-00001 · Cited by 188
Self-citation
Allopregnanolone inhibits learning in the Morris water maze
Johansson, I., Birzniece, V., Lindblad, C., Olsson, T., & Bäckström, T. C. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02414-9 · Cited by 193
Socially evaluated cold pressor stress after instrumental learning favors habits over goal-directed action
Schwabe, L., & Wolf, O. T. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.12.010 · Cited by 204
The Inverted “U-Shaped” Dose-Effect Relationships in Learning and Memory: Modulation of Arousal and Consolidation
Baldi, E., & Bucherelli, C. (2005) · Nonlinearity in Biology, Toxicology, Medicine · doi:10.2201/nonlin.003.01.002 · Cited by 220
Stress, Glucocorticoids, and Memory: A Meta-analytic Review
Sauro, M. D., Jorgensen, R. S., & Pedlow, C. T. (2003) · Stress · doi:10.1080/10253890310001616482 · Cited by 184
Systems mediating acute glucocorticoid effects on memory consolidation and retrieval
Roozendaal, B. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.09.015 · Cited by 191
Self-citation
Amygdalar Inactivation Blocks Stress-Induced Impairments in Hippocampal Long-Term Potentiation and Spatial Memory
Kim, J. J., Koo, J. W., Lee, H. J., & Han, J.-S. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4623-04.2005 · Cited by 184
Pharmacological treatment of PTSD – Established and new approaches
Steckler, T., & Risbrough, V. B. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.06.012 · Cited by 188
The Amygdala, the Hippocampus, and Emotional Modulation of Memory
Richter‐Levin, G. (2004) · The Neuroscientist · doi:10.1177/1073858403259955 · Cited by 182
Preventive Effect of β-Adrenoceptor Blockade on Glucocorticoid-Induced Memory Retrieval Deficits
de Quervain, D. J. ‐., Aerni, A., & Roozendaal, B. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.6.967 · Cited by 181
Self-citation
Understanding posttraumatic stress disorder through fear conditioning, extinction and reconsolidation
Careaga, M. B. L., Girardi, C. E. N., & Suchecki, D. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.08.023 · Cited by 193
Stress and emotional memory retrieval: Effects of sex and cortisol response
Buchanan, T. W., & Tranel, D. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.07.003 · Cited by 179
The corticoid environment: a determining factor for neural progenitors' survival in the adult hippocampus
Wong, E. Y. H., & Herbert, J. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03717.x · Cited by 182
Influence of prenatal noise and music on the spatial memory and neurogenesis in the hippocampus of developing rats
Kim, H. K., Lee, M., Chang, H., Lee, T.-H., Lee, H., Shin, M.-C., Shin, M., Won, R., Shin, H.-S., & Kim, C. (2005) · Brain and Development · doi:10.1016/j.braindev.2005.05.008 · Cited by 176
Overcoming the effects of stress on synaptic plasticity in the intact hippocampus: rapid actions of serotonergic and antidepressant agents
Shakesby, A. C., Anwyl, R., & Rowan, M. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03638.2002 · Cited by 173
Memory consolidation in human sleep depends on inhibition of glucocorticoid release
Plihal, W., & Born, J. (1999) · NeuroReport · doi:10.1097/00001756-199909090-00009 · Cited by 171
Efficacy of Hydrocortisone in Preventing Posttraumatic Stress Disorder Following Critical Illness and Major Surgery
Schelling, G., Roozendaal, B., Krauseneck, T., Schmoelz, M., de Quervain, D. J. ‐., & Briegel, J. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.005 · Cited by 173
Self-citation
Sexual Experience Promotes Adult Neurogenesis in the Hippocampus Despite an Initial Elevation in Stress Hormones
Leuner, B., Glasper, E. R., & Gould, E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011597 · Cited by 175
Glucocorticoids for the treatment of post-traumatic stress disorder and phobias: A novel therapeutic approach
de Quervain, D. J. ‐., & Margraf, J. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.068 · Cited by 170
A Facilitative Role for Corticosterone in the Acquisition of a Spatial Task Under Moderate StressPreprint
Akirav, I., Kozenicky, M., Tal, D., Sandi, C., Venero, C., & Richter‐Levin, G. (2004) · Learning & Memory · doi:10.1101/lm.61704 · Cited by 173
Glucocorticoids Orchestrate Divergent Effects on Mood through Adult Neurogenesis
Lehmann, M. L., Brachman, R. A., Martinowich, K., Schloesser, R. J., & Herkenham, M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3878-12.2013 · Cited by 168
Memory enhancement of classical fear conditioning by post-training injections of corticosterone in rats
Hui, G. K. (2003) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2003.09.002 · Cited by 168
Endogenous cortisol level interacts with noradrenergic activation in the human amygdala
van Stegeren, A. H., Wolf, O. T., Everaerd, W. T. A. M., Scheltens, P., Barkhof, F., & Rombouts, S. A. R. B. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.05.008 · Cited by 170
Mineralocorticoid Receptor Blockade Prevents Stress-Induced Modulation of Multiple Memory Systems in the Human Brain
Schwabe, L., Tegenthoff, M., Höffken, O., & Wolf, O. T. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.06.001 · Cited by 164
Glucocorticoids act on glutamatergic pathways to affect memory processes
Sandi, C. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.01.006 · Cited by 167
Using the Single Prolonged Stress Model to Examine the Pathophysiology of PTSD
de Souza, R. R., Noble, L. J., & McIntyre, C. K. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00615 · Cited by 169
Timing is essential for rapid effects of corticosterone on synaptic potentiation in the mouse hippocampus
Wiegert, O., Joëls, M., & Krugers, H. (2006) · Learning & Memory · doi:10.1101/lm.87706 · Cited by 162
Antistress Effect of TRPV1 Channel on Synaptic Plasticity and Spatial Memory
Li, H.-B., Mao, R., Zhang, J., Yang, Y., Cao, J., & Xu, L. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.020 · Cited by 165
Prenatal stress modifies hippocampal synaptic plasticity and spatial learning in young rat offspring
Yang, J., Han, H., Cao, J., Li, L., & Xu, L. (2006) · Hippocampus · doi:10.1002/hipo.20181 · Cited by 163
Acute Stress Induces Selective Alterations in Cost/Benefit Decision-Making
Shafiei, N., Gray, M. E., Viau, V., & Floresco, S. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.69 · Cited by 160
Memory retrieval impairment induced by hippocampal CA3 lesions is blocked by adrenocortical suppression
Roozendaal, B., Phillips, R. G., Power, A. E., Brooke, S. M., Sapolsky, R. M., & McGaugh, J. L. (2001) · Nature Neuroscience · doi:10.1038/nn766 · Cited by 160
Self-citation
Autobiographic memory impairment following acute cortisol administration
Buß, C., Wolf, O. T., Witt, J., & Hellhammer, D. H. (2003) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2003.09.006 · Cited by 156
Depression as a risk factor for Alzheimer’s disease: Genes, steroids, cytokines and neurogenesis – What do we need to know?
Herbert, J., & Lucassen, P. J. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.12.001 · Cited by 150
Adrenal stress hormones, amygdala activation, and memory for emotionally arousing experiences
Roozendaal, B., Barsegyan, A., & Lee, S. (2007) · Progress in Brain Research · doi:10.1016/s0079-6123(07)67006-x · Cited by 154
Self-citation
Postnatal environment can counteract prenatal effects on cognitive ability, cell proliferation, and synaptic protein expression
Koo, J. W., Park, C. H., Choi, S. H., Kim, N. J., Kim, H., Choe, J. C., & Suh, Y. (2003) · The FASEB Journal · doi:10.1096/fj.02-1032fje · Cited by 155
Enriched environment experience overcomes the memory deficits and depressive-like behavior induced by early life stress.
Cui, M., Yang, Y., Yang, J., Zhang, J., Han, H., Ma, W., Li, H., Mao, R., Xu, L., Hao, W., et al. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.05.048 · Cited by 153
Programming hyperglycaemia in the rat through prenatal exposure to glucocorticoids-fetal effect or maternal influence?
Nyirenda, M., Welberg, L., & Seckl, J. R. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1700653 · Cited by 152
The associations among hippocampal volume, cortisol reactivity, and memory performance in healthy young men
Pruessner, M., Pruessner, J. C., Hellhammer, D. H., Bruce Pike, G., & Lupien, S. J. (2007) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2006.12.007 · Cited by 150
Neuroactive steroid effects on cognitive functions with a focus on the serotonin and GABA systems
Birzniece, V., Bäckström, T. C., Johansson, I., Lindblad, C., Lundgren, P., Löfgren, M., Olsson, T., Ragagnin, G., Taube, M., Türkmen, Ş., et al. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.11.001 · Cited by 151
Effects of testosterone on spatial learning and memory in adult male rats
Spritzer, M. D., Daviau, E. D., Coneeny, M. K., Engelman, S. M., Prince, W., & Rodriguez-Wisdom, K. N. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.01.009 · Cited by 132
Effects of Zizyphus jujube Extract on Memory and Learning Impairment Induced by Bilateral Electric Lesions of the Nucleus Basalis of Meynert in Rat
Rabiei, Z., Rafieian‐Kopaei, M., Heidarian, E., Saghaei, E., & Mokhtari, S. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1232-8 · Cited by 149
Ten years of research with the Socially Evaluated Cold Pressor Test: Data from the past and guidelines for the future
Schwabe, L., & Schächinger, H. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.03.010 · Cited by 159
Role of the Basolateral Amygdala in Memory Consolidation
McINTYRE, C. K., POWER, A. E., ROOZENDAAL, B., & McGAUGH, J. L. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07088.x · Cited by 147
Self-citation
Corticosterone Impairs Insulin-Stimulated Translocation of GLUT4 in the Rat Hippocampus
Piroli, G. G., Grillo, C. A., Reznikov, L. R., Adams, S., McEwen, B. S., Charron, M. J., & Reagan, L. P. (2007) · Neuroendocrinology · doi:10.1159/000101694 · Cited by 152
The endocannabinoid system: An emotional buffer in the modulation of memory function
Morena, M., & Campolongo, P. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.12.010 · Cited by 153
Complex Motor Learning and Police Training: Applied, Cognitive, and Clinical Perspectives
Nota, P. M. D., & Huhta, J. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.01797 · Cited by 177
Development of the HPA axis: Where and when do sex differences manifest?
Panagiotakopoulos, L., & Neigh, G. N. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.03.002 · Cited by 148
Are BDNF and glucocorticoid activities calibrated?
Jeanneteau, F. D., & Chao, M. V. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.09.017 · Cited by 150
Antidepressant activity of memory-enhancing drugs in the reduction of submissive behavior model
Knapp, R. J., Goldenberg, R., Shuck, C., Cecil, A., Watkins, J. B., Miller, C., Crites, G. J., & Malatyńska, E. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01338-9 · Cited by 142
Different hippocampal molecular requirements for short- and long-term retrieval of one-trial avoidance learning
Izquierdo, L. A., Barros, D. M., Ardenghi, P. G., Pereira, P., Rodrigues, C., Choi, H., Medina, J. H., & Izquierdo, I. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00137-6 · Cited by 141
Allostasis, Allostatic Load, and the Aging Nervous System: Role of Excitatory Amino Acids and Excitotoxicity
McEwen, B. S. (2000) · Neurochemical Research · doi:10.1023/a:1007687911139 · Cited by 141
Stress Impairs Reconsolidation of Drug Memory via Glucocorticoid Receptors in the Basolateral Amygdala
Wang, X., Zhao, M., Ghitza, U. E., Li, Y., & Lü, L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0750-08.2008 · Cited by 143
Glucocorticoids interact with the hippocampal endocannabinoid system in impairing retrieval of contextual fear memory
Atsak, P., Hauer, D., Campolongo, P., Schelling, G., McGaugh, J. L., & Roozendaal, B. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200742109 · Cited by 140
Self-citation
Differential activation of hippocampus and amygdala following spatial learning under stress
Akirav, I., Sandi, C., & Richter‐Levin, G. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01687.x · Cited by 142
Emotion-Induced Amnesia in Rats: Working Memory-Specific Impairment, Corticosterone-Memory Correlation, and Fear Versus Arousal Effects on Memory
Woodson, J. C., Macintosh, D., Fleshner, M., & Diamond, D. M. (2003) · Learning & Memory · doi:10.1101/lm.62903 · Cited by 169
Hormonal responses to different sexually related conditions in male rats
Bonilla‐Jaime, H., Vázquez-Palacios, G., Arteaga‐Silva, M., & Retana‐Márquez, S. (2005) · Hormones and Behavior · doi:10.1016/j.yhbeh.2005.08.005 · Cited by 139
Resveratrol prevents cognitive deficits induced by chronic unpredictable mild stress: Sirt1/miR-134 signalling pathway regulates CREB/BDNF expression in hippocampus in vivo and in vitro
Shen, J., Xu, L., Qu, C., Sun, H., & Zhang, J. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.04.050 · Cited by 144
The Role of the Hypothalamus–Pituitary–Adrenal (HPA) Axis in Test-Induced Anxiety: Assessments, Physiological Responses, and Molecular Details
Hinds, J. A., & Sánchez, E. R. (2022) · Stresses · doi:10.3390/stresses2010011 · Cited by 165
Enhancing exposure therapy for anxiety disorders with glucocorticoids: From basic mechanisms of emotional learning to clinical applications
Bentz, D., Michael, T., de Quervain, D. J. ‐., & Wilhelm, F. H. (2009) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2009.10.011 · Cited by 136
Early life manipulations alter learning and memory in rats
Kosten, T. A., Kim, J. J., & Lee, H. J. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.003 · Cited by 136

Authors: de Quervain, D. J.-F., Roozendaal, B., & McGaugh, J. L.
Affiliations: University of California, Irvine (US)
Corresponding author: Roozendaal, Benno
ORCID: de Quervain, Dominique J.-F.
Roozendaal, Benno
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1998-08
Volume: 394
Issue: 6695
Pages: 787-790
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/29542
OpenAlex: W1724698019
Cited by: 1,182
References: 22
Citations by year: 2026: 28 · 2025: 21 · 2024: 27 · 2023: 15 · 2022: 26 · 2021: 25 · 2020: 37 · 2019: 39 · 2018: 52 · 2017: 51 · 2016: 46 · 2015: 47 · 2014: 54 · 2013: 73 · 2012: 58
FWCI: 17.16
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Institut National de la Santé et de la Recherche Médicale
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords: stress, glucocorticoids, corticosterone, memory retrieval, long-term spatial memory, water maze, footshock, metyrapone, adrenocortical function, memory consolidation, memory acquisition, spatial navigation
MeSH terms: Animals, Glucocorticoids, Hypothalamo-Hypophyseal System, Male, Memory Disorders, Pituitary-Adrenal System, Retention, Psychology, Stress, Physiological, Rats, Sprague-Dawley, Maze Learning, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Stress and glucocorticoids impair retrieval of long-term spatial memory

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks