Cited by 1,182Memory and Neural MechanismsStress Responses and CortisolMemory Processes and Influences

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Stress and glucocorticoids impair retrieval of long-term spatial memory

de Quervain, Dominique J.-F., Roozendaal, Benno, McGaugh, James L.·1998·Nature

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Abstract

Extensive evidence from animal and human studies indicates that stress and glucocorticoids influence cognitive function. Previous studies have focused exclusively on glucocorticoid effects on acquisition and long-term storage of newly acquired information. Here we report that stress and glucocorticoids also affect memory retrieval. We show that rats have impaired performance in a water-maze spatial task after being given footshock 30 min before retention testing but are not impaired when footshock is given 2 min or 4 h before testing. These time-dependent effects on retention performance correspond to the circulating corticosterone levels at the time of testing, which suggests that the retention impairment is directly related to increased adrenocortical function. In support of this idea, we find that suppression of corticosterone synthesis with metyrapone blocks the stress-induced retention impairment. In addition, systemic corticosterone administered to non-stressed rats 30 min before retention testing induces dose-dependent retention impairment. The impairing effects of stress and glucocorticoids on retention are not due to disruption of spatial navigation per se. Our results indicate that besides the well described effects of stress and glucocorticoids on acquisition and consolidation processes, glucocorticoids also affect memory retrieval mechanisms.

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Authors: de Quervain, D. J.-F., Roozendaal, B., & McGaugh, J. L.
Affiliations: University of California, Irvine (US)
Corresponding author: Roozendaal, Benno
ORCID: de Quervain, Dominique J.-F.
Roozendaal, Benno
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1998-08
Volume: 394
Issue: 6695
Pages: 787-790
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/29542
OpenAlex: W1724698019
Cited by: 1,182
References: 22
Citations by year: 2026: 28 · 2025: 21 · 2024: 27 · 2023: 15 · 2022: 26 · 2021: 25 · 2020: 37 · 2019: 39 · 2018: 52 · 2017: 51 · 2016: 46 · 2015: 47 · 2014: 54 · 2013: 73 · 2012: 58
FWCI: 17.16
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Institut National de la Santé et de la Recherche Médicale
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords: stress, glucocorticoids, corticosterone, memory retrieval, long-term spatial memory, water maze, footshock, metyrapone, adrenocortical function, memory consolidation, memory acquisition, spatial navigation
MeSH terms: Animals, Glucocorticoids, Hypothalamo-Hypophyseal System, Male, Memory Disorders, Pituitary-Adrenal System, Retention, Psychology, Stress, Physiological, Rats, Sprague-Dawley, Maze Learning, Rats

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Stress and glucocorticoids impair retrieval of long-term spatial memory

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