The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Conformations of immunoglobulin hypervariable regions
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The relation between the divergence of sequence and structure in proteins.
Chothia, C., & Lesk, A. M. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04288.x · Cited by 2,458
Self-citationReplacing the complementarity-determining regions in a human antibody with those from a mouse
Jones, P. T., Dear, P. H., Foote, J., Neuberger, M. S., & Winter, G. (1986) · Nature · doi:10.1038/321522a0 · Cited by 1,406
Wu, T. T., & Kabat, E. A. (1970) · The Journal of Experimental Medicine · doi:10.1084/jem.132.2.211 · Cited by 1,340
Cited by
Comparative Protein Structure Modeling of Genes and Genomes
Martí-Renom, M. A., Stuart, A. C., Fiser, A., Sánchez, R., Melo, F., & Šali, A. (2000) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.29.1.291 · Cited by 3,169
Modeling of loops in protein structures
Fiser, A., Do, R. K. G., & Šali, A. (2000) · Protein Science · doi:10.1110/ps.9.9.1753 · Cited by 2,116
Diversity in the CDR3 Region of VH Is Sufficient for Most Antibody Specificities
Xu, J. L., & Davis, M. M. (2000) · Immunity · doi:10.1016/s1074-7613(00)00006-6 · Cited by 779
Knappik, A., Ge, L., Honegger, A., Pack, P., Fischer, M., Wellnhofer, G., Hoess, A., Wölle, J., Plückthun, A., & Virnekäs, B. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.3444 · Cited by 728
Comparative protein structure modeling using MODELLER
Webb, B., & Sali, A. (2016) · Current Protocols in Protein Science · doi:10.1002/cpps.20 · Cited by 730
“…accurate and efficient when a database of specific loops is created to address the modeling of the same class of loops, such as β -hairpins (Sibanda et al., 1989), or loops on a specific fold, such as the hypervariable regions in the immunoglobulin fold (Chothia and Lesk, 1987; Chothia et al., 1989).”
BackgroundSAbDab: the structural antibody database
Dunbar, J., Krawczyk, K., Leem, J., Baker, T., Fuchs, A., Georges, G., Shi, J., & Deane, C. M. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1043 · Cited by 674
The structural basis of antibody–antigen recognition
Sela-Culang, I., Kunik, V., & Ofran, Y. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00302 · Cited by 530
A new clustering of antibody CDR loop conformations
North, B., Lehmann, A., & Dunbrack, R. L. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.10.030 · Cited by 380
Five computational developability guidelines for therapeutic antibody profiling
Raybould, M. I. J., Marks, C., Krawczyk, K., Taddese, B., Nowak, J., Lewis, A. P., Bujotzek, A., Shi, J., & Deane, C. M. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1810576116 · Cited by 357
β-Hairpin Peptidomimetics: Design, Structures and Biological Activities
Robinson, J. A. (2008) · Accounts of Chemical Research · doi:10.1021/ar700259k · Cited by 321
Comparative analysis of nanobody sequence and structure data
Mitchell, L. S., & Colwell, L. J. (2018) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.25497 · Cited by 233
Wang, M., Cang, Z., & Wei, G.-W. (2020) · Nature Machine Intelligence · doi:10.1038/s42256-020-0149-6 · Cited by 202
Prediction of aggregation prone regions of therapeutic proteins
Chennamsetty, N., Voynov, V., Kayser, V., Helk, B., & Trout, B. L. (2010) · The Journal of Physical Chemistry B · doi:10.1021/jp911706q · Cited by 200
AB ‐Bind: Antibody binding mutational database for computational affinity predictions
Sirin, S., Apgar, J. R., Bennett, E. M., & Keating, A. E. (2016) · Protein Science · doi:10.1002/pro.2829 · Cited by 179
Structural basis of epitope recognition by heavy-chain camelid antibodies
Zavrtanik, U., Lukan, J., Loris, R., Lah, J., & Hadži, S. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.09.002 · Cited by 169
ABlooper: fast accurate antibody CDR loop structure prediction with accuracy estimation
Abanades, B., Georges, G., Bujotzek, A., & Deane, C. M. (2022) · Bioinformatics · doi:10.1093/bioinformatics/btac016 · Cited by 157
Analysis of nanobody paratopes reveals greater diversity than classical antibodies
Mitchell, L. S., & Colwell, L. J. (2018) · Protein Engineering Design and Selection · doi:10.1093/protein/gzy017 · Cited by 138
Kunik, V., Ashkenazi, S., & Ofran, Y. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks480 · Cited by 132
Almagro, J. C., Beavers, M. P., Hernandez‐Guzman, F., Maier, J., Shaulsky, J., Butenhof, K., Labute, P., Thorsteinson, N., Kelly, K., Teplyakov, A., et al. (2011) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.23130 · Cited by 131
ABangle: characterising the VH-VL orientation in antibodies
Dunbar, J., Fuchs, A., Shi, J., & Deane, C. M. (2013) · Protein Engineering Design and Selection · doi:10.1093/protein/gzt020 · Cited by 125
Structural consensus among antibodies defines the antigen binding site
Kunik, V., Peters, B., & Ofran, Y. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002388 · Cited by 117
Lapidoth, G. D., Baran, D., Pszolla, G. M., Norn, C., Alon, A., Tyka, M. D., & Fleishman, S. J. (2015) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.24779 · Cited by 107
Dondelinger, M., Filée, P., Sauvage, E., Quinting, B., Muyldermans, S., Galleni, M., & Vandevenne, M. S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02278 · Cited by 107
Kunik, V., & Ofran, Y. (2013) · Protein Engineering Design and Selection · doi:10.1093/protein/gzt027 · Cited by 96
AbDb: antibody structure database-a database of PDB-derived antibody structures
Ferdous, S., & Martin, A. C. R. (2018) · Database · doi:10.1093/database/bay040 · Cited by 87
The diversity of H 3 loops determines the antigen‐binding tendencies of antibody CDR loops
Tsuchiya, Y., & Mizuguchi, K. (2016) · Protein Science · doi:10.1002/pro.2874 · Cited by 86
Wang, X., Singh, S. K., & Kumar, S. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0143-5 · Cited by 79
Antibody modeling assessment II. Structures and models
Teplyakov, A., Luo, J., Obmolova, G., Malia, T. J., Sweet, R., Stanfield, R. L., Kodangattil, S., Almagro, J. C., & Gilliland, G. L. (2014) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.24554 · Cited by 72
Prediction of VH-VL domain orientation for antibody variable domain modeling
Bujotzek, A., Dunbar, J., Lipsmeier, F., Schäfer, W., Antes, I., Deane, C. M., & Georges, G. (2015) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.24756 · Cited by 56
Shirai, H., Ikeda, K., Yamashita, K., Tsuchiya, Y., Sarmiento, J., Liang, S., Morokata, T., Mizuguchi, K., Higo, J., Standley, D. M., et al. (2014) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.24591 · Cited by 51
Structurally mapping antibody repertoires
Krawczyk, K., Kelm, S., Kovaltsuk, A., Galson, J. D., Kelly, D., Trück, J., Regep, C., Leem, J., Wong, W. K., Nowak, J., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01698 · Cited by 42
Polonsky, K., Pupko, T., & Freund, N. T. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2300150 · Cited by 41
Computational tools for aiding rational antibody design
Krawczyk, K., Dunbar, J., & Deane, C. M. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6637-0_21 · Cited by 26
SARS-CoV-2 antibodies recognize 23 distinct epitopic sites on the receptor binding domain
Jiang, J., Boughter, C. T., Ahmad, J., Natarajan, K., Boyd, L. F., Meier-Schellersheim, M., & Margulies, D. H. (2023) · Communications Biology · doi:10.1038/s42003-023-05332-w · Cited by 24
Greenshields-Watson, A., Abanades, B., & Deane, C. M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1352703 · Cited by 7
Information-driven modelling of antibody–antigen complexes
Ambrosetti, F., Jiménez-García, B., Roel-Touris, J., & Bonvin, A. M. J. J. (2019) · SSRN Electronic Journal · doi:10.2139/ssrn.3362436 · Cited by 2
Metadata
- Authors
- Chothia, C., Lesk, A. M., Tramontano, A., Levitt, M., Smith-Gill, S. J., Air, G., Sheriff, S., Padlan, E. A., Davies, D., Tulip, W. R., Colman, P. M., Spinelli, S., Alzari, P. M., & Poljak, R. J.
- Venue
- Nature
- Published
- 1989-12
- Volume
- 342
- Issue
- 6252
- Pages
- 877-883
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2074534136
- Cited by
- 1,185
- References
- 3
- FWCI
- 14.51
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
