PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

NF-κB regulation in the immune system

Li, Q., & Verma, I. M. (2002) · Nature Reviews Immunology · doi:10.1038/nri910 · Cited by 4,007

Signaling to NF-κB

Hayden, M. S., & Ghosh, S. (2004) · Genes & Development · doi:10.1101/gad.1228704 · Cited by 3,842

Missing Pieces in the NF-κB Puzzle

Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884

NF-κB, the first quarter-century: remarkable progress and outstanding questions

Hayden, M. S., & Ghosh, S. (2012) · Genes & Development · doi:10.1101/gad.183434.111 · Cited by 1,693

Positive and negative selection of T cells

Starr, T. K., Jameson, S. C., & Hogquist, K. A. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141107 · Cited by 1,601

NF-κB and the immune response

Hayden, M. S., West, A. P., & Ghosh, S. (2006) · Oncogene · doi:10.1038/sj.onc.1209943 · Cited by 1,178

CD28 and CTLA-4 coreceptor expression and signal transduction

Rudd, C. E., Taylor, A., & Schneider, H. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00770.x · Cited by 898

PD‐1 inhibits T‐cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθ

Sheppard, K.-A., Fitz, L. J., Lee, J. M., Benander, C., George, J. A., Wooters, J., Qiu, Y., Jussif, J. M., Carter, L. L., Wood, C. R., et al. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.083 · Cited by 791

Phosphorylation of IRS proteins, insulin action, and insulin resistance

Boura-Halfon, S., & Zick, Y. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90437.2008 · Cited by 598

The immunological synapse

Dustin, M. L. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0161 · Cited by 502

Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development

Hwang, J.-R., Byeon, Y., Kim, D., & Park, S.-G. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0435-8 · Cited by 470

Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling.

Rudd, C. E., & Schneider, H. (2003) · Nature Reviews Immunology · doi:10.1038/nri1131 · Cited by 392

PKC-θ knockout mice are protected from fat-induced insulin resistance

Kim, J. K., Fillmore, J. J., Sunshine, M. J., Albrecht, B., Higashimori, T., Kim, D.-W., Liu, Z.-X., Soos, T. J., Cline, G. W., O’Brien, W. R., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422230 · Cited by 500

CARMA1, BCL-10 and MALT1 in lymphocyte development and activation

Thome, M. (2004) · Nature Reviews Immunology · doi:10.1038/nri1352 · Cited by 391

Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation

Uehata, T., Iwasaki, H., Vandenbon, A., Matsushita, K., Hernandez-Cuellar, E., Kuniyoshi, K., Satoh, T., Mino, T., Suzuki, Y., Standley, D. M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.034 · Cited by 349

Protein Kinase C θ Affects Ca2+ Mobilization and NFAT Activation in Primary Mouse T Cells

Pfeifhofer, C., Kofler, K., Gruber, T., Ghaffari Tabrizi, N., Lutz, C., Maly, K., Leitges, M., & Baier, G. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20020234 · Cited by 326

Independent roles for IL-2 and GATA-3 in stimulating naive CD4+ T cells to generate a Th2-inducing cytokine environment

Yamane, H., Zhu, J., & Paul, W. E. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051304 · Cited by 285

An Enigmatic Tail of CD28 Signaling

Boomer, J. S., & Green, J. M. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002436 · Cited by 283

A20 Negatively Regulates T Cell Receptor Signaling to NF-κB by Cleaving Malt1 Ubiquitin Chains

Düwel, M., Welteke, V., Oeckinghaus, A., Baens, M., Kloo, B., Ferch, U., Darnay, B. G., Ruland, J., Marynen, P., & Krappmann, D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803313 · Cited by 233

Signal Transduction by the High-Affinity Immunoglobulin E Receptor FcεRI: Coupling Form to Function

Nadler, M. J. S., Matthews, S. A., Turner, H., & Kinet, J.-P. (2001) · Advances in Immunology · doi:10.1016/s0065-2776(01)76022-1 · Cited by 203

Chemical proteomic map of dimethyl fumarate–sensitive cysteines in primary human T cells

Blewett, M. M., Xie, J., Zaro, B. W., Backus, K. M., Altman, A., Teijaro, J. R., & Cravatt, B. F. (2016) · Science Signaling · doi:10.1126/scisignal.aaf7694 · Cited by 194

Protein Kinase C-θ Is an Early Survival Factor Required for Differentiation of Effector CD8+ T Cells

Barouch-Bentov, R., Lemmens, E. E., Hu, J., Janssen, E. M., Droin, N. M., Song, J., Schoenberger, S. P., & Altman, A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.8.5126 · Cited by 64

Protein Kinase C-θ Promotes Th17 Differentiation via Upregulation of Stat3

Kwon, M.-J., Ma, J., Ding, Y., Wang, R., & Sun, Z. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102941 · Cited by 56

Involvement of Thyroid Hormones in the Alterations of T-Cell Immunity and Tumor Progression Induced by Chronic Stress

Frick, L. R., Rapanelli, M., Bussmann, U. A., Klecha, A. J., Arcos, M. L. B., Genaro, A. M., & Cremaschi, G. A. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.12.013 · Cited by 55

Diacylglycerol kinases in T cell tolerance and effector function

Chen, S. S., Hu, Z., & Zhong, X.-P. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00130 · Cited by 44

Mitogenic signals through CD28 activate the protein kinase Ctheta-NF-kappaB pathway in primary peripheral T cells.

Dennehy, K. M. (2003) · International Immunology · doi:10.1093/intimm/dxg063 · Cited by 36