The association between telomere length and cancer risk in population studies
Open accessAbstract
Telomeres are crucial in the maintenance of chromosome integrity and genomic stability. A series of epidemiological studies have examined the association between telomere length and the risk of cancers, but the findings remain conflicting. We performed literature review and meta-analysis to demonstrate the relationship between telomere length and cancer risk. A total of 23,379 cases and 68,792 controls from 51 publications with 62 population studies were included in this meta-analysis to assess the association between overall cancer or cancer-specific risk and telomere length. General association and dose-response relationship were evaluated based on two and three groups, respectively. The estimates of association were evaluated with odds ratios and 95% confidence intervals by the random-effects or fixed-effects model based on heterogeneity test. We observed a non-significant association between short telomeres and overall risk of cancer. Convincing evidence was observed for the association of short telomeres with an increased risk of gastrointestinal tumor and head and neck cancer. Significant dose-response associations were also observed for gastrointestinal tumor and head and neck cancer. Our findings indicate that telomeres may play diverse roles in different cancers and short telomeres may be risk factors for the tumors of digestive system.
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If TERT is upregulated, then telomerase activity will be increased, allowing cells to overcome replicative senescence; telomeres become dysfunctional, allowing breakage-fusion-bridge cycles, chromosomal fusions, gene amplifications, derived chromosome imbalances, and complex non-reciprocal translocations, a hallmark feature of adult solid tumors and genomic instability.
“This is important because if TERT is upregulated, then TA will be increased, allowing cells to overcome replicative senescence. Doing so, telomeres become dysfunctional, which allows for continuous “breakage-fusion-bridge” cycles, chromosomal fusions, gene amplifications, derived chromosome imbalances, and the formation of complex non-reciprocal translocations to take place, a hallmark feature of”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [178]
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Stress and telomere shortening: Insights from cellular mechanisms
Lin, J., & Epel, E. S. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101507 · Cited by 398 · see citing works
Telomere Length and All-Cause Mortality: A Meta-analysis
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Targeting telomerase for cancer therapy
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Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length
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Beginning at the ends: telomeres and human disease
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Bring It to an End: Does Telomeres Size Matter?
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Molecular mechanisms by which oxidative DNA damage promotes telomerase activity
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Urban environment and cancer in wildlife: available evidence and future research avenues
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Epigenetics as a key link between psychosocial stress and aging: concepts, evidence, mechanisms
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Biomarkers of ageing: Current state‐of‐art, challenges, and opportunities
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Telomeres, cellular senescence, and aging: past and future
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Neighborhood disadvantage and biological aging biomarkers among breast cancer patients
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NRF2 signaling pathway and telomere length in aging and age-related diseases
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DNA damage in obesity: Initiator, promoter and predictor of cancer
Usman, M., & Volpi, E. V. (2018) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2018.08.002 · Cited by 51 · see citing works
Telomere Homeostasis: Interplay with Magnesium
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Highly Aggressive Metastatic Melanoma Cells Unable to Maintain Telomere Length
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Higher maternal vitamin D concentrations are associated with longer leukocyte telomeres in newborns
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Trade-offs in aging lung diseases
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The impact of social and environmental factors on cancer biology in Black Americans
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Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy
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A Cross-Sectional Analysis of Telomere Length and Sleep in the Women’s Health Initiative
Grieshober, L., Wactawski‐Wende, J., Blair, R. H., Mu, L., Liu, J., Nie, J., Carty, C. L., Hale, L. E., Kroenke, C. H., LaCroix, A. Z., et al. (2019) · American Journal of Epidemiology · doi:10.1093/aje/kwz134 · Cited by 27 · see citing works
In vivo biomarkers of structural and functional brain development and aging in humans
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Association between shortened telomere length and rheumatoid arthritis
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Genetic determinants of telomere length and cancer risk
Nelson, C. P., & Codd, V. (2020) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2020.02.007 · Cited by 27 · see citing works
Aerobic capacity and telomere length in human skeletal muscle and leukocytes across the lifespan
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The Role of Single-Nucleotide Polymorphisms in the Function of Candidate Tumor Suppressor ALDH1L1
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Li, Y., Sundquist, K., Wang, X., Zhang, N., Hedelius, A., Sundquist, J., & Memon, A. A. (2021) · Cancers · doi:10.3390/cancers13153842 · Cited by 25 · see citing works
Association between shortened telomere length and systemic lupus erythematosus: a meta-analysis
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Sex-specific associations between telomere length and candidate miRNA expression in placenta
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Moderate-to-severe obstructive sleep apnea is associated with telomere lengthening
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Telogator: a method for reporting chromosome-specific telomere lengths from long reads
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Reliable blood cancer cells' telomere length evaluation by qPCR
Ropio, J., Chebly, A., Ferrer, J., Prochazkova‐Carlotti, M., Idrissi, Y., Martin, L. A., Cappellen, D., Pham‐Ledard, A., Soares, P., Merlio, J., et al. (2020) · Cancer Medicine · doi:10.1002/cam4.2816 · Cited by 18 · see citing works
Are Biological Consequences of Childhood Exposures Detectable in Telomere Length Decades Later?
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Maternal diet and offspring telomere length: a systematic review
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Television Watching and Telomere Length Among Adults in Southwest China
Xue, H., Liu, Q., Tian, G., Quan, L., Zhao, Y. B., & Cheng, G. (2017) · American Journal of Public Health · doi:10.2105/ajph.2017.303879 · Cited by 15 · see citing works
Telomere Maintenance in Pediatric Cancer
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Biological Basis of Breast Cancer-Related Disparities in Precision Oncology Era
Neagu, A.-N., Bruno, P. S., Johnson, K. R., Ballestas, G., & Darie, C. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25074113 · Cited by 14 · see citing works
Filaggrin variations are associated with PAH metabolites in urine and DNA alterations in blood
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Regulation of Gene Expression by Telomere Position Effect
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How stem cells keep telomeres in check
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Cadmium Exposure and Blood Telomere Length in Female University Students in Japan
Mizuno, Y., Konishi, S., Imai, H., Fujimori, E., Kojima, N., & Yoshinaga, J. (2019) · Biological Trace Element Research · doi:10.1007/s12011-019-1656-3 · Cited by 12 · see citing works
Telomere Length and Telomerase Activity as Potential Biomarkers for Gastrointestinal Cancer
Loukopoulou, C., Νikolouzakis, Τ. Κ., Koliarakis, I., Vakonaki, E., & Tsiaoussis, J. (2024) · Cancers · doi:10.3390/cancers16193370 · Cited by 13 · see citing works
Telomere erosion in NF1 tumorigenesis
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Thriveni, K., Raju, A., Kumar, R. V., Krishnamurthy, S., & Chaluvarayaswamy, R. (2018) · Clinical Breast Cancer · doi:10.1016/j.clbc.2018.07.021 · Cited by 11 · see citing works
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Ko, J. M. Y., Tsang, K. H., Dai, W., Choi, S. S. A., Leong, M. M., Ngan, R. K., Kwong, D. L., Cheng, A. C. K., Lee, A. W. M., Ng, W. T., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.31617 · Cited by 10 · see citing works
Leukocyte Telomere Length and Pancreatic Cancer Risk
Antwi, S. O., & Petersen, G. M. (2018) · Pancreas · doi:10.1097/mpa.0000000000000995 · Cited by 10 · see citing works
Antwi, S. O., Bamlet, W. R., Rabe, K. G., Cawthon, R., Umudi, I., Druliner, B. R., Sicotte, H., Oberg, A. L., Jatoi, A., Boardman, L. A., et al. (2020) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-19-1597 · Cited by 10 · see citing works
Telomere Length and Its Relation to Human Health
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Self-citationACYP2 polymorphisms are associated with the risk of liver cancer in a Han Chinese population
Chen, Z., Sun, Y., Xu, Z., Xu, J., Li, J., Yan, M., Li, J., Jin, T., & Lin, H. (2017) · Oncotarget · doi:10.18632/oncotarget.18574 · Cited by 9 · see citing works
Leucocytes telomere length and breast cancer risk/ susceptibility: A case-control study
Pavanello, S., Varesco, L., Gismondi, V., Bruzzi, P., & Bolognesi, C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197522 · Cited by 9 · see citing works
Prognostic Value of Peripheral Blood Lymphocyte Telomere Length in Gynecologic Malignant Tumors
Shanta, K., Nakayama, K., Ishikawa, M., Ishibashi, T., Yamashita, H., Sato, S., Sasamori, H., Sawada, K., Kurose, S., Mahmud, H. M., et al. (2020) · Cancers · doi:10.3390/cancers12061469 · Cited by 9 · see citing works
Telomere reprogramming during fetal life in low socioeconomic mothers
Farrukh, S., Baig, S., Hussain, R., Shahid, A., & Khan, S. T. (2019) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-019-0007-4 · Cited by 9 · see citing works
Akıncılar, S. C., Fidan, K., Kumar, N., Ng, Q. F., Majee, P., Wu, L., Han, D. J., Chan, C. H. T., Chua, J. Y. H., Idzham, K., et al. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01706-w · Cited by 8 · see citing works
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Evolution of Telomerase Inhibitors: A Review on Key Patents from 2015 to 2023
Dey, R., Vishwakarma, K., Patel, B., Vyas, V. K., & Bhatt, H. (2024) · ChemistrySelect · doi:10.1002/slct.202404444 · Cited by 7 · see citing works
Autophagy: The convergence point of aging and cancer
Pandey, A., Goswami, A., Jithin, B., & Shukla, S. (2025) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2025.101986 · Cited by 7 · see citing works
Telomerase and Cancer: A Complex Relationship
Fossel, M., & Whittemore, K. (2021) · OBM Geriatrics · doi:10.21926/obm.geriatr.2101156 · Cited by 7 · see citing works
Maternal opioid use is reflected on leukocyte telomere length of male newborns
Abad, F. R. M., Khalili, P., Jalali, F., Pirsadeghi, A., Nadimi, A. E., Manshoori, A., & Jalali, Z. (2021) · PLoS ONE · doi:10.1371/journal.pone.0261013 · Cited by 7 · see citing works
Prefrontally modulated vagal neuroimmunomodulation is associated with telomere length
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Altered expression of telomere‐associated genes in leukocytes among BRCA1 and BRCA2 carriers
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Land Use Mix and Leukocyte Telomere Length in Mexican Americans
Zhao, H., Shen, J., Chang, D. W., Ye, Y., Wu, X., Chow, W., & Zhang, K. (2020) · Scientific Reports · doi:10.1038/s41598-021-99171-6 · Cited by 6 · see citing works
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- Authors
- Zhu, X., Han, W., Xue, W., Zou, Y., Xie, C., Du, J., & Jin, G.
- Affiliations
- Nanjing Medical University (CN)
- Corresponding author
- Jin, Guangfu
- Venue
- Scientific Reports
- Published
- 2016-02-26
- Volume
- 6
- Issue
- 1
- Pages
- 22243-22243
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4768100
- OpenAlex
- W2301840504
- Cited by
- 146
- References
- 80
- Citations by year
- 2026: 3 · 2025: 15 · 2024: 16 · 2023: 8 · 2022: 9 · 2021: 15 · 2020: 16 · 2019: 19 · 2018: 20 · 2017: 18 · 2016: 6 · 2015: 1
- FWCI
- 16.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81422042, 81373090)
- National Key Research and Development Program of China (2013CB910304)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Keywords
- telomere length, cancer risk, short telomeres, gastrointestinal cancer, head and neck cancer, dose-response relationship, genome stability, chromosome integrity, cancer risk factors
- MeSH terms
- Gastrointestinal Neoplasms, Head and Neck Neoplasms, Humans, Risk Factors, Telomere, Risk Assessment, Telomere Homeostasis, Telomere Shortening
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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