Iron homeostasis: insights from genetics and animal models

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

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Cloning and characterization of a mammalian proton-coupled metal-ion transporter

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The ferritins: molecular properties, iron storage function and cellular regulation

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Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

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A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation

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A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism

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Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

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The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22

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Transferrin receptor is necessary for development of erythrocytes and the nervous system

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Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux

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Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron

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Iron, brain ageing and neurodegenerative disorders

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The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis

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Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 ( USF2 ) knockout mice

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Iron metabolism and toxicity

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Severe iron deficiency anemia in transgenic mice expressing liver hepcidin

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Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network

Muckenthaler, M. U., Galy, B., & Hentze, M. W. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155521 · Cited by 701

Phenotype-genotype relationships in monogenic disease: lessons from the thalassaemias

Weatherall, D. J. (2001) · Nature Reviews Genetics · doi:10.1038/35066048 · Cited by 692

Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease

Weinstein, D. A., Roy, C. N., Fleming, M. D., Loda, M. F., Wolfsdorf, J. I., & Andrews, N. C. (2002) · Blood · doi:10.1182/blood-2002-04-1260 · Cited by 632

Forging a field: the golden age of iron biology.

Andrews, N. C. (2008) · Blood · doi:10.1182/blood-2007-12-077388 · Cited by 623

Mechanisms of mammalian iron homeostasis

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Autosomal-dominant hemochrom-atosis is associated with a mutation in the ferroportin (SLC11A3) gene

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Lactoferrin: Multifunctional roles of lactoferrin: a critical overview

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Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: Implications for regulation and cellular function

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Divalent-metal transport by NRAMP proteins at the interface of host–pathogen interactions

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Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver

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Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation

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Insight into the evolution of the iron oxidation pathways

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Enhanced antiproliferative activity of transferrin-conjugated paclitaxel-loaded nanoparticles is mediated via sustained intracellular drug retention

Sahoo, S. K., & Labhasetwar, V. (2005) · Molecular Pharmaceutics · doi:10.1021/mp050032z · Cited by 340

Shared and distinct mechanisms of iron acquisition by bacterial and fungal pathogens of humans

Caza, M., & Kronstad, J. W. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00080 · Cited by 306

A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency

Jabara, H. H., Boyden, S. E., Chou, J., Ramesh, N., Massaad, M. J., Benson, H., Bainter, W., Fraulino, D., Rahimov, F., Sieff, C., et al. (2016) · Nature Genetics · doi:10.1038/ng.3465 · Cited by 279

Iron, manganese, and cobalt transport by Nramp1 (Slc11a1) and Nramp2 (Slc11a2) expressed at the plasma membrane

Forbes, J. R., & Gros, P. (2003) · Blood · doi:10.1182/blood-2003-02-0425 · Cited by 288

Iron-withholding strategy in innate immunity

Ong, S. T., Shan Ho, J. Z., Ho, B., & Ding, J. L. (2006) · Immunobiology · doi:10.1016/j.imbio.2006.02.004 · Cited by 269

Hepcidin Revisited, Disulfide Connectivity, Dynamics, and Structure

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Iron and Reactive Oxygen Species: Friends or Foes of Cancer Cells?

Bystrom, L. M., Guzman, M. L., & Rivella, S. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5014 · Cited by 212

Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mkmice

Canonne-Hergaux, F., Zhang, A.-S., Ponka, P., & Gros, P. (2001) · Blood · doi:10.1182/blood.v98.13.3823 · Cited by 169

Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2

Foot, N. J., Dalton, H. E., Shearwin-Whyatt, L. M., Dorstyn, L., Tan, S.-S., Yang, B., & Kumar, S. (2008) · Blood · doi:10.1182/blood-2008-04-150953 · Cited by 143

Alternative Splicing Regulates the Subcellular Localization of Divalent Metal Transporter 1 Isoforms

Tabuchi, M., Tanaka, N., Nishida-Kitayama, J., Ohno, H., & Kishi, F. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-03-0165 · Cited by 141

Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis

Diaz-Ochoa, V. E., Jellbauer, S., Klaus, S., & Raffatellu, M. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00002 · Cited by 129

Small-Molecule Fluorescent Probes for Binding- and Activity-Based Sensing of Redox-Active Biological Metals

Grover, K., Koblova, A., Pezacki, A. T., Chang, C. J., & New, E. J. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00819 · Cited by 129

Transferrin receptor 1 is differentially required in lymphocyte development

Ned, R. M., Swat, W., & Andrews, N. C. (2003) · Blood · doi:10.1182/blood-2003-04-1086 · Cited by 120

Comparative analysis of mouse hepcidin 1 and 2 genes: evidence for different patterns of expression and co‐inducibility during iron overload 1

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Functions and regulation of lipocalin-2 in gut-origin sepsis: a narrative review

Lu, F., Inoue, K., Kato, J., Minamishima, S., & Morisaki, H. (2019) · Critical Care · doi:10.1186/s13054-019-2550-2 · Cited by 60

Iron Chelation Suppresses Ferritin Upregulation and Attenuates Vascular Dysfunction in the Aorta of Angiotensin II–Infused Rats

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Pathways of iron acquisition and utilization in Leishmania

Flannery, A. R., Renberg, R. L., & Andrews, N. W. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.07.018 · Cited by 50

The cytoplasmic domain of transferrin receptor 2 dictates its stability and response to holo-transferrin in Hep3B cells.

Chen, J., & Enns, C. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610127200 · Cited by 30

The haemochromatosis protein HFE induces an apparent iron-deficient phenotype in H1299 cells that is not corrected by co-expression of beta2-microglobulin

WANG, J., CHEN, G., & PANTOPOULOS, K. (2003) · Biochemical Journal · doi:10.1042/bj20021607 · Cited by 28

Regulation of heme utilization and homeostasis in Candida albicans

Andrawes, N., Weissman, Z., Pinsky, M., Moshe, S., Berman, J., & Kornitzer, D. (2022) · PLOS Genetics · doi:10.1371/journal.pgen.1010390 · Cited by 17