Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: Implications for regulation and cellular function

Hubert, Nadia; Hentze, Matthias W.

doi:10.1073/pnas.192423399

Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: Implications for regulation and cellular function

Divalent metal transporter 1 (DMT1) mediates apical iron uptake into duodenal enterocytes and also transfers iron from the endosome into the cytosol after cellular uptake via the transferrin receptor. Hence, mutations in DMT1 cause systemic iron deficiency and anemia. DMT1 mRNA levels are increas…