Cited by 2,468Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

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Neural consequences of enviromental enrichment

van Praag, Henriette, Kempermann, Gerd, Gage, Fred H.·2000·Nature Reviews Neuroscience

DOI 10.1038/35044558

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Abstract

Neuronal plasticity is a central theme of modern neurobiology, from cellular and molecular mechanisms of synapse formation in Drosophila to behavioural recovery from strokes in elderly humans. Although the methods used to measure plastic responses differ, the stimuli required to elicit plasticity are thought to be activity-dependent. In this article, we focus on the neuronal changes that occur in response to complex stimulation by an enriched environment. We emphasize the behavioural and neurobiological consequences of specific elements of enrichment, especially exercise and learning.

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A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
Self-citation
More hippocampal neurons in adult mice living in an enriched environment
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997) · Nature · doi:10.1038/386493a0 · Cited by 3,586
Self-citation
The period of susceptibility to the physiological effects of unilateral eye closure in kittens
Hubel, D. H., & Wiesel, T. N. (1970) · The Journal of Physiology · doi:10.1113/jphysiol.1970.sp009022 · Cited by 3,030
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904
Self-citation
Learning enhances adult neurogenesis in the hippocampal formation
Gould, E., Beylin, A., Tanapat, P., Reeves, A., & Shors, T. J. (1999) · Nature Neuroscience · doi:10.1038/6365 · Cited by 2,157
Hippocampal electrical activity and voluntary movement in the rat
Vanderwolf, C. H. (1969) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(69)90092-3 · Cited by 1,928
Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats
Plotsky, P. M., & Meaney, M. J. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90189-v · Cited by 1,638
Long-Lasting Neurotrophin-Induced Enhancement of Synaptic Transmission in the Adult Hippocampus
Kang, H., & Schuman, E. M. (1995) · Science · doi:10.1126/science.7886457 · Cited by 1,354
Epidermal Growth Factor and Fibroblast Growth Factor-2 Have Different Effects on Neural Progenitors in the Adult Rat Brain
Kuhn, H. G., Winkler, J., Kempermann, G., Thal, L. J., & Gage, F. H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-15-05820.1997 · Cited by 1,214
Self-citation

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Show all 135 references

Research works printed but not linked: 2

Hebb, D. O. The Organization of Behaviour (Wiley, New York, 1949 ).
Malberg, J. E. et al. Chronic antidepressant administration increases granule cell genesis in the hippocampus of the adult male rat. J. Neurosci. (in the press).

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Background
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Background
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Background
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Background
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Retracted
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Yang, J., Li, W., Liu, X., Li, Z., Li, H., Yang, G., Xu, L., & Li, L. (2006) · Brain Research · doi:10.1016/j.brainres.2006.10.028 · Cited by 44
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Fernández, C. I., COLLAZO, J., Bauzá, Y., Castellanos, M. R., & LÓPEZ, O. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1297.012 · Cited by 44
Rearing in an enriched environment attenuated hyperactivity and inattention in the Spontaneously Hypertensive Rats, an animal model of Attention-Deficit Hyperactivity Disorder
Botanas, C. J., Lee, H., de la Peña, J. B., Peña, I. J. D., Woo, T., Kim, H. J., Han, D. H., Kim, B.-N., & Cheong, J. H. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.11.035 · Cited by 44
Welfare Assessment and Humane End Points
Morton, D. B., & Hau, J. (2010) · CRC Press eBooks · doi:10.1201/b10416-19 · Cited by 44
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Schenk, S., Lech, R. K., & Boris Suchan, A. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.08.027 · Cited by 51
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Imperio, C. G., McFalls, A. J., Hadad, N., Blanco-Berdugo, L., Masser, D. R., Colechio, E. M., Coffey, A. A., Bixler, G. V., Stanford, D. R., Vrana, K. E., et al. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.06.037 · Cited by 45
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Rojas‐Carvajal, M., Sequeira‐Cordero, A., & Brenes, J. C. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15160 · Cited by 51
Environmental enrichment improves lifelong persistent behavioral and epigenetic changes induced by early-life stress
Borba, L. A., Broseghini, L. D. R., Manosso, L. M., de Moura, A. B., Botelho, M. E. M., Arent, C. O., Behenck, J. P., Hilsendeger, A., Kammer, L. H., Valvassori, S. S., et al. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.04.008 · Cited by 44
Increasing Adult Hippocampal Neurogenesis Promotes Resilience in a Mouse Model of Depression
Planchez, B., Lagunas, N., Guisquet, A. L., Legrand, M., Surget, A., Hen, R., & Belzung, C. (2021) · Cells · doi:10.3390/cells10050972 · Cited by 45
“However, it seems that the ventral hippocampus was not affected by UCMS in our study, possibly due to the fact that before the UCMS regimen, mice were housed in an enriched environment, which could have partially prevented the effects of stress [31].”
Background
Rehabilitation and outcome following pediatric traumatic brain injury
Beaulieu, C. L. (2002) · Surgical Clinics of North America · doi:10.1016/s0039-6109(02)00009-9 · Cited by 44
Environmental enrichment improves mating success in fruit flies
Dukas, R., & Mooers, A. Ø. (2003) · Animal Behaviour · doi:10.1006/anbe.2002.2261 · Cited by 44
Response of sagittal plane gait kinematics to weight-supported treadmill training and functional neuromuscular stimulation following stroke
Daly, J. J., Roenigk, K. L., Butler, K. M., Gansen, J. L., Fredrickson, E. K., Marsolais, E. B., Rogers, J. M., & Ruff, R. L. (2004) · The Journal of Rehabilitation Research and Development · doi:10.1682/jrrd.2003.08.0120 · Cited by 44
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Combining an Antioxidant‐Fortified Diet with Behavioral Enrichment Leads to Cognitive Improvement and Reduced Brain Pathology in Aging Canines
Head, E. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1396.004 · Cited by 44
Enriching early adult environment affects the copulation behaviour of a tephritid fly
Dı́az-Fleischer, F., Arredondo, J., & Aluja, M. (2009) · Journal of Experimental Biology · doi:10.1242/jeb.027342 · Cited by 43
Life-span plasticity of the brain and cognition: From questions to evidence and back
Raz, N., & Lindenberger, U. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.10.003 · Cited by 44
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Effect of Physical and Social Components of Enriched Environment on Astrocytes Proliferation in Rats After Cerebral Ischemia/Reperfusion Injury
Chen, X., Zhang, X., Liao, W., & Wan, Q. (2017) · Neurochemical Research · doi:10.1007/s11064-016-2172-x · Cited by 41
Long-term effects of enriched environment following neonatal hypoxia-ischemia on behavior, BDNF and synaptophysin levels in rat hippocampus: Effect of combined treatment with G-CSF
Griva, M., Lagoudaki, R., Touloumi, O., Nousiopoulou, E., Karalis, F., Georgiou, T., Kokaraki, G., Simeonidou, C., Tata, D. Α., & Spandou, E. (2017) · Brain Research · doi:10.1016/j.brainres.2017.05.004 · Cited by 44
“Although the prevailing view in the literature is that EE exerts beneficial effect on cognitive and sensorimotor functions in normal animals (Garthe et al., 2016; Leggio et al., 2005; Nilsson et al., 1999; van Praag et al., 2000), conflicting data are also available.”
Background
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Seong, H., Park, J., & Kim, Y. (2017) · Biological Research For Nursing · doi:10.1177/1099800417730400 · Cited by 44
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Weiler, M., Casseb, R. F., de Campos, B. M., Teixeira, C. V. L., Carletti‐Cassani, A. F. M. K., Vicentini, J. E., Magalhães, T. N. C., de Almeira, D. Q., Talib, L. L., Forlenza, O. V., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00255 · Cited by 45
Physical activity and cognition: A narrative review of the evidence for older adults
Etnier, J. L., Drollette, E. S., & Slutsky, A. B. (2018) · Psychology of sport and exercise · doi:10.1016/j.psychsport.2018.12.006 · Cited by 55
Enriched environment effect on lipopolysaccharide-induced spatial learning, memory impairment and hippocampal inflammatory cytokine levels in male rats
Keymoradzadeh, A., Hedayati, M., Abedinzade, M., Gazor, R., Rostampour, M., & Taleghani, B. K. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112814 · Cited by 43
System Consolidation of Spatial Memories in Mice: Effects of Enriched Environment
Bonaccorsi, J., Cintoli, S., Mastrogiacomo, R., Baldanzi, S., Braschi, C., Pizzorusso, T., Cenni, M. C., & Berardi, N. (2013) · Neural Plasticity · doi:10.1155/2013/956312 · Cited by 45
Effectiveness of Neurofeedback Training as a Treatment for Opioid-Dependent Patients
Dehghani-Arani, F., Rostami, R., & Nostratabadi, M. (2010) · Clinical EEG and Neuroscience · doi:10.1177/155005941004100313 · Cited by 43
Enriched environment restores impaired hippocampal long‐term potentiation and water maze performance induced by developmental lead exposure in rats
Cao, X., Huang, S., & Ruan, D. (2008) · Developmental Psychobiology · doi:10.1002/dev.20287 · Cited by 43
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Hamilton, G. F., Boschen, K. E., Goodlett, C. R., Greenough, W. T., & Klintsova, A. Y. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01726.x · Cited by 48
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Xie, H., Wu, Y., Jia, J., Liu, G., Zhang, Q., Yu, K., Guo, Z., Shen, L. W., & Hu, R. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.04.032 · Cited by 42
Environmental enrichment increases amphetamine-induced glutamate neurotransmission in the nucleus accumbens: A neurochemical study
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“…induced 41 DEGs (23 up- and 18 downregulated) (Supplementary Figures 4A,B) enriched for Gene Ontology terms like morphogenesis involved in neuron differentiation, cognition, and learning and memory (Supplementary Figure 4C) that have been implicated with EE effects before (van Praag et al., 2000).”
Background
DARPP‐32 in the orchestration of responses to positive natural stimuli
Scheggi, S., Montis, M. G. D., & Gambarana, C. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14558 · Cited by 44
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Mora-Gallegos, A., & Fornaguera, J. (2018) · Behavioural Processes · doi:10.1016/j.beproc.2018.10.022 · Cited by 42

Authors: van Praag, H., Kempermann, G., & Gage, F. H.
Affiliations: Salk Institute for Biological Studies (US)
ORCID: Kempermann, Gerd
Gage, Fred H.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2000-12
Volume: 1
Issue: 3
Pages: 191-198
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/35044558
OpenAlex: W2096192426
Cited by: 2,468
References: 135
Citations by year: 2026: 59 · 2025: 80 · 2024: 77 · 2023: 92 · 2022: 99 · 2021: 113 · 2020: 131 · 2019: 100 · 2018: 134 · 2017: 112 · 2016: 115 · 2015: 133 · 2014: 133 · 2013: 142 · 2012: 129
FWCI: 1.55
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Foundation for the National Institutes of Health
Christopher and Dana Reeve Foundation
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: environmental enrichment, neuroplasticity, activity-dependent plasticity, physical activity, learning, behavioral recovery, synaptogenesis, stroke recovery
MeSH terms: Animals, Brain, Cell Division, Environment, Controlled, Humans, Neuronal Plasticity, Sensory Deprivation

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Neural consequences of enviromental enrichment

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