Cited by 2,468Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

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Neural consequences of enviromental enrichment

van Praag, Henriette, Kempermann, Gerd, Gage, Fred H.·2000·Nature Reviews Neuroscience

DOI 10.1038/35044558

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Abstract

Neuronal plasticity is a central theme of modern neurobiology, from cellular and molecular mechanisms of synapse formation in Drosophila to behavioural recovery from strokes in elderly humans. Although the methods used to measure plastic responses differ, the stimuli required to elicit plasticity are thought to be activity-dependent. In this article, we focus on the neuronal changes that occur in response to complex stimulation by an enriched environment. We emphasize the behavioural and neurobiological consequences of specific elements of enrichment, especially exercise and learning.

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Temporal Effects of Environmental Enrichment–Mediated Functional Improvement After Experimental Traumatic Brain Injury in Rats
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Background

Authors: van Praag, H., Kempermann, G., & Gage, F. H.
Affiliations: Salk Institute for Biological Studies (US)
ORCID: Kempermann, Gerd
Gage, Fred H.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2000-12
Volume: 1
Issue: 3
Pages: 191-198
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/35044558
OpenAlex: W2096192426
Cited by: 2,468
References: 135
Citations by year: 2026: 59 · 2025: 80 · 2024: 77 · 2023: 92 · 2022: 99 · 2021: 113 · 2020: 131 · 2019: 100 · 2018: 134 · 2017: 112 · 2016: 115 · 2015: 133 · 2014: 133 · 2013: 142 · 2012: 129
FWCI: 1.55
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Foundation for the National Institutes of Health
Christopher and Dana Reeve Foundation
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: environmental enrichment, neuroplasticity, activity-dependent plasticity, physical activity, learning, behavioral recovery, synaptogenesis, stroke recovery
MeSH terms: Animals, Brain, Cell Division, Environment, Controlled, Humans, Neuronal Plasticity, Sensory Deprivation

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Neural consequences of enviromental enrichment

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