Cited by 2,468Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

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Neural consequences of enviromental enrichment

van Praag, Henriette, Kempermann, Gerd, Gage, Fred H.·2000·Nature Reviews Neuroscience

DOI 10.1038/35044558

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Abstract

Neuronal plasticity is a central theme of modern neurobiology, from cellular and molecular mechanisms of synapse formation in Drosophila to behavioural recovery from strokes in elderly humans. Although the methods used to measure plastic responses differ, the stimuli required to elicit plasticity are thought to be activity-dependent. In this article, we focus on the neuronal changes that occur in response to complex stimulation by an enriched environment. We emphasize the behavioural and neurobiological consequences of specific elements of enrichment, especially exercise and learning.

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A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
Self-citation
More hippocampal neurons in adult mice living in an enriched environment
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997) · Nature · doi:10.1038/386493a0 · Cited by 3,586
Self-citation
The period of susceptibility to the physiological effects of unilateral eye closure in kittens
Hubel, D. H., & Wiesel, T. N. (1970) · The Journal of Physiology · doi:10.1113/jphysiol.1970.sp009022 · Cited by 3,030
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904
Self-citation
Learning enhances adult neurogenesis in the hippocampal formation
Gould, E., Beylin, A., Tanapat, P., Reeves, A., & Shors, T. J. (1999) · Nature Neuroscience · doi:10.1038/6365 · Cited by 2,157
Hippocampal electrical activity and voluntary movement in the rat
Vanderwolf, C. H. (1969) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(69)90092-3 · Cited by 1,928
Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats
Plotsky, P. M., & Meaney, M. J. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90189-v · Cited by 1,638
Long-Lasting Neurotrophin-Induced Enhancement of Synaptic Transmission in the Adult Hippocampus
Kang, H., & Schuman, E. M. (1995) · Science · doi:10.1126/science.7886457 · Cited by 1,354
Epidermal Growth Factor and Fibroblast Growth Factor-2 Have Different Effects on Neural Progenitors in the Adult Rat Brain
Kuhn, H. G., Winkler, J., Kempermann, G., Thal, L. J., & Gage, F. H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-15-05820.1997 · Cited by 1,214
Self-citation

Flagged first, then by citations

Show all 135 references

Research works printed but not linked: 2

Hebb, D. O. The Organization of Behaviour (Wiley, New York, 1949 ).
Malberg, J. E. et al. Chronic antidepressant administration increases granule cell genesis in the hippocampus of the adult male rat. J. Neurosci. (in the press).

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Self-citation
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Background
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Background
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How STRANGE are your study animals?
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Authors: van Praag, H., Kempermann, G., & Gage, F. H.
Affiliations: Salk Institute for Biological Studies (US)
ORCID: Kempermann, Gerd
Gage, Fred H.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2000-12
Volume: 1
Issue: 3
Pages: 191-198
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/35044558
OpenAlex: W2096192426
Cited by: 2,468
References: 135
Citations by year: 2026: 59 · 2025: 80 · 2024: 77 · 2023: 92 · 2022: 99 · 2021: 113 · 2020: 131 · 2019: 100 · 2018: 134 · 2017: 112 · 2016: 115 · 2015: 133 · 2014: 133 · 2013: 142 · 2012: 129
FWCI: 1.55
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Foundation for the National Institutes of Health
Christopher and Dana Reeve Foundation
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: environmental enrichment, neuroplasticity, activity-dependent plasticity, physical activity, learning, behavioral recovery, synaptogenesis, stroke recovery
MeSH terms: Animals, Brain, Cell Division, Environment, Controlled, Humans, Neuronal Plasticity, Sensory Deprivation

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Neural consequences of enviromental enrichment

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