Cited by 269Transcranial Magnetic Stimulation StudiesMotor Control and AdaptationNeuroscience and Neuropharmacology Research

Modifying motor learning through gating and homeostatic metaplasticity

Ziemann, Ulf, Siebner, Hartwig R.·2008·Brain Stimulation

Abstract

Synaptic plasticity in the motor cortex is involved at least in some forms of motor learning. Recent evidence showed that the extent of practice-dependent plasticity in the motor cortex can be purposefully enhanced by experimental manipulation. One way of improving motor learning is to transiently increase the excitability of the motor cortex during motor learning. This can be achieved by weakening the excitability of intracortical inhibitory circuits concurrently with practice. This principle is being referred to as "gating." Another strategy to boost learning is to decrease the threshold for induction of synaptic plasticity by lowering neuronal activity in the motor cortex before practice. This approach invokes homeostatic metaplasticity. Here we highlight how transcranial brain stimulation can exploit gating and homeostatic metaplasticity to enhance motor learning in healthy subjects and in patients after stroke.

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Crossref · 10.1016/j.brs.2007.08.003

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Authors
Ziemann, U., & Siebner, H. R.
Affiliations
  • Goethe University Frankfurt (DE)
  • Christian-Albrechts-Universität zu Kiel (DE)
Corresponding author
Ziemann, Ulf
Venue
Brain Stimulation
Publisher
Elsevier BV
Published
2008-01
Volume
1
Issue
1
Pages
60-66
ISSN
  • 1876-4754 (ISSN-L)
  • 1935-861X
OpenAlex
W2031034560
Cited by
269
References
73
Citations by year
2026: 5 · 2025: 13 · 2024: 13 · 2023: 12 · 2022: 15 · 2021: 24 · 2020: 19 · 2019: 19 · 2018: 21 · 2017: 12 · 2016: 19 · 2015: 26 · 2014: 16 · 2013: 19 · 2012: 15
FWCI
0.35
Type
journal article
Language
en
Open access
closed
Locations
  • Brain stimulation (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
motor learning, motor cortex, synaptic plasticity, gating, intracortical inhibition, cortical excitability, transcranial brain stimulation, stroke rehabilitation
MeSH terms
Stroke Rehabilitation, Homeostasis, Humans, Learning, Motor Activity, Motor Cortex, Neuronal Plasticity, Stroke, Transcranial Magnetic Stimulation

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